Abstract
A problem area in the interpretation of chromatographic data is the determination of the purity of a detected peak. The problem arises in deciding whether a peak is due solely to one component, or is caused by the simultaneous elution of two or more components. Whilst a number of multivariate statistical techniques are available to assess the number of components contributing to a given signal, they may require a significant amount of computer power to provide an answer, and are prone to noise-induced errors. As part of a programme of research aimed at developing an intelligent system for mobile phase optimisation, we have developed a knowledge based systems approach to the problem of peak homogeneity assessment. The expert system applies a number of simple numerical tests to the three-dimensional dataset produced by a photodiode-array detector and assess the results in light of the chromatographic signal. © 1989.
| Original language | English |
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| Pages (from-to) | 59-67 |
| Number of pages | 9 |
| Journal | Journal of Chromatography A |
| Volume | 465 |
| Issue number | 2 |
| Publication status | Published - 1989 |