Approaches to the synthesis of 1H-[1]benzothieno[2,3-d]imidazoles and thieno[2,3-d]imidazoles

Peter N. Preston, Sudesh K. Sood

Research output: Contribution to journalArticlepeer-review


Photolysis of three NN-disubstituted 3-amino-2-nitrobenzo[b]thiophen derivatives gave mixtures of 2-nitro-benzo[b]thiophen-3-ol and benzo[b]thiophen-2,3-quinone2-mono-oxime. 3-Benzylamino-2-nitrobenzo[b]thiophen was cyclised to an N-oxide under basic conditions. This N-oxide was converted into a benzoyloxy-derivative and was also deoxygenated to give 2-phenyl[1]benzothieno[2,3-d]imidazole. Reduction of 3-formamido-2-nitrobenzo[b] thiophen gave [1]benzothieno[2,3-d]imidazol-2(3H)-one in low yield. Efforts to extend these cyclisation processes to analogous thiophen derivatives did not succeed.

Original languageEnglish
Pages (from-to)80-83
Number of pages4
JournalJournal of the Chemical Society, Perkin Transactions 1
Issue number1
Publication statusPublished - 1976


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