Applying linked data approaches to pharmacology: architectural decisions and implementation

Alasdair J G Gray, Paul Groth, Antonis Loizou, Sune Askjaer, Christian Y A Brenninkmeijer, Kees Burger, Christine Chichester, Chris T Evelo, Carole Goble, Lee Harland, Steve Pettifer, Mark Thompson, Andra Waagmeester, Antony J Williams

Research output: Contribution to journalArticle

Abstract

The discovery of new medicines requires pharmacologists to interact with a number of information sources ranging from tabular data to scientific papers, and other specialized formats. In this application report, we describe a linked data platform for integrating multiple pharmacology datasets that form the basis for several drug discovery applications. The functionality offered by the platform has been drawn from a collection of prioritised drug discovery business questions created as part of the Open PHACTS project, a collaboration of research institutions and major pharmaceutical companies. We describe the architecture of the platform focusing on seven design decisions that drove its development with the aim of informing others developing similar software in this or other domains. The utility of the platform is demonstrated by the variety of drug discovery applications being built to access the integrated data.
LanguageEnglish
Pages101-113
JournalSemantic Web
Volume5
Issue number2
DOIs
Publication statusPublished - 2014

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Gray, A. J. G., Groth, P., Loizou, A., Askjaer, S., Brenninkmeijer, C. Y. A., Burger, K., ... Williams, A. J. (2014). Applying linked data approaches to pharmacology: architectural decisions and implementation. Semantic Web, 5(2), 101-113. https://doi.org/10.3233/SW-2012-0088
Gray, Alasdair J G ; Groth, Paul ; Loizou, Antonis ; Askjaer, Sune ; Brenninkmeijer, Christian Y A ; Burger, Kees ; Chichester, Christine ; Evelo, Chris T ; Goble, Carole ; Harland, Lee ; Pettifer, Steve ; Thompson, Mark ; Waagmeester, Andra ; Williams, Antony J. / Applying linked data approaches to pharmacology : architectural decisions and implementation. In: Semantic Web. 2014 ; Vol. 5, No. 2. pp. 101-113.
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Gray, AJG, Groth, P, Loizou, A, Askjaer, S, Brenninkmeijer, CYA, Burger, K, Chichester, C, Evelo, CT, Goble, C, Harland, L, Pettifer, S, Thompson, M, Waagmeester, A & Williams, AJ 2014, 'Applying linked data approaches to pharmacology: architectural decisions and implementation', Semantic Web, vol. 5, no. 2, pp. 101-113. https://doi.org/10.3233/SW-2012-0088

Applying linked data approaches to pharmacology : architectural decisions and implementation. / Gray, Alasdair J G; Groth, Paul; Loizou, Antonis; Askjaer, Sune; Brenninkmeijer, Christian Y A; Burger, Kees; Chichester, Christine; Evelo, Chris T; Goble, Carole; Harland, Lee; Pettifer, Steve; Thompson, Mark; Waagmeester, Andra; Williams, Antony J.

In: Semantic Web, Vol. 5, No. 2, 2014, p. 101-113.

Research output: Contribution to journalArticle

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