Applying linked data approaches to pharmacology: architectural decisions and implementation

Alasdair J G Gray; Paul Groth; Antonis Loizou; Sune Askjaer; Christian Y A Brenninkmeijer; Kees Burger; Christine Chichester; Chris T Evelo; Carole Goble; Lee Harland; Steve Pettifer; Mark Thompson; Andra Waagmeester; Antony J Williams

doi:10.3233/SW-2012-0088

Applying linked data approaches to pharmacology: architectural decisions and implementation

Alasdair J G Gray, Paul Groth, Antonis Loizou, Sune Askjaer, Christian Y A Brenninkmeijer, Kees Burger, Christine Chichester, Chris T Evelo, Carole Goble, Lee Harland, Steve Pettifer, Mark Thompson, Andra Waagmeester, Antony J Williams

Research output: Contribution to journal › Article

42 Citations (Scopus)

Abstract

The discovery of new medicines requires pharmacologists to interact with a number of information sources ranging from tabular data to scientific papers, and other specialized formats. In this application report, we describe a linked data platform for integrating multiple pharmacology datasets that form the basis for several drug discovery applications. The functionality offered by the platform has been drawn from a collection of prioritised drug discovery business questions created as part of the Open PHACTS project, a collaboration of research institutions and major pharmaceutical companies. We describe the architecture of the platform focusing on seven design decisions that drove its development with the aim of informing others developing similar software in this or other domains. The utility of the platform is demonstrated by the variety of drug discovery applications being built to access the integrated data.

Original language	English
Pages (from-to)	101-113
Journal	Semantic Web
Volume	5
Issue number	2
DOIs	https://doi.org/10.3233/SW-2012-0088
Publication status	Published - 2014

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10.3233/SW-2012-0088

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Profiles

Alasdair J. G. Gray

A.J.G.Gray@hw.ac.uk

School of Mathematical & Computer Sciences - Associate Professor
School of Mathematical & Computer Sciences, Computer Science - Associate Professor
Research Centres and Themes, Energy Academy - Associate Professor

Person: Academic (Research & Teaching)

Cite this

Gray, A. J. G., Groth, P., Loizou, A., Askjaer, S., Brenninkmeijer, C. Y. A., Burger, K., Chichester, C., Evelo, C. T., Goble, C., Harland, L., Pettifer, S., Thompson, M., Waagmeester, A., & Williams, A. J. (2014). Applying linked data approaches to pharmacology: architectural decisions and implementation. Semantic Web, 5(2), 101-113. https://doi.org/10.3233/SW-2012-0088

Gray, Alasdair J G ; Groth, Paul ; Loizou, Antonis ; Askjaer, Sune ; Brenninkmeijer, Christian Y A ; Burger, Kees ; Chichester, Christine ; Evelo, Chris T ; Goble, Carole ; Harland, Lee ; Pettifer, Steve ; Thompson, Mark ; Waagmeester, Andra ; Williams, Antony J. / Applying linked data approaches to pharmacology : architectural decisions and implementation. In: Semantic Web. 2014 ; Vol. 5, No. 2. pp. 101-113.

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Applying linked data approaches to pharmacology : architectural decisions and implementation. / Gray, Alasdair J G; Groth, Paul; Loizou, Antonis; Askjaer, Sune; Brenninkmeijer, Christian Y A; Burger, Kees; Chichester, Christine; Evelo, Chris T; Goble, Carole; Harland, Lee; Pettifer, Steve; Thompson, Mark; Waagmeester, Andra; Williams, Antony J.

In: Semantic Web, Vol. 5, No. 2, 2014, p. 101-113.

Research output: Contribution to journal › Article

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AU - Williams, Antony J

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