Polarization speckle is a rapidly developed field. Unlike laser speckle, polarization speckle consists of stochastic interference patterns with spatially random polarizations, amplitudes and phases. We have been working in this exciting research field, developing techniques to generate polarization patterns from skin. We hypothesize that polarization speckle patterns could be used in biomedical applications, especially, for detecting and monitoring skin cancers, the most common neoplasmas for white populations around the world. This paper describes our effort in developing two polarization speckle devices. One of them captures the Stokes parameters So and S1 simultaneously, and another one captures all four Stokes parameters So, S1, S2, and S3 in one-shot, within milliseconds. Hence these two devices could be used in medical clinics and assessed skin conditions in-vivo. In order to validate our hypothesis, we conducted a series of three clinical studies. These are early pilot studies, and the results suggest that the devices have potential to detect and monitor skin cancers.