Applications of polarization speckle in skin cancer detection and monitoring

Tim K. Lee, Lioudmila Tchvialeva, Jamie Phillips, Daniel C. Louie, Jianhua Zhao, Wei Wang, Harvey Lui, Sunil Kalia

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Citations (Scopus)

Abstract

Polarization speckle is a rapidly developed field. Unlike laser speckle, polarization speckle consists of stochastic interference patterns with spatially random polarizations, amplitudes and phases. We have been working in this exciting research field, developing techniques to generate polarization patterns from skin. We hypothesize that polarization speckle patterns could be used in biomedical applications, especially, for detecting and monitoring skin cancers, the most common neoplasmas for white populations around the world. This paper describes our effort in developing two polarization speckle devices. One of them captures the Stokes parameters So and S1 simultaneously, and another one captures all four Stokes parameters So, S1, S2, and S3 in one-shot, within milliseconds. Hence these two devices could be used in medical clinics and assessed skin conditions in-vivo. In order to validate our hypothesis, we conducted a series of three clinical studies. These are early pilot studies, and the results suggest that the devices have potential to detect and monitor skin cancers.

Original languageEnglish
Title of host publicationThirteenth International Conference on Correlation Optics
EditorsOleg V. Angelsky
PublisherSPIE
ISBN (Electronic)9781510617285
ISBN (Print)9781510617278
DOIs
Publication statusPublished - 18 Jan 2018
Event13th International Conference on Correlation Optics 2017 - Chernivtsi, Ukraine
Duration: 11 Sep 201715 Sep 2017

Publication series

NameProceedings of SPIE
PublisherSPIE
Volume10612
ISSN (Print)0277-786X
ISSN (Electronic)1996-756X

Conference

Conference13th International Conference on Correlation Optics 2017
CountryUkraine
CityChernivtsi
Period11/09/1715/09/17

Keywords

  • Cancer detection
  • Diffuse reflectance spectroscopy
  • One-shot method
  • Polarization
  • Polarization speckle
  • Skin cancer
  • Stokes parameters
  • Treatment monitoring

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Computer Science Applications
  • Applied Mathematics
  • Electrical and Electronic Engineering

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  • Cite this

    Lee, T. K., Tchvialeva, L., Phillips, J., Louie, D. C., Zhao, J., Wang, W., Lui, H., & Kalia, S. (2018). Applications of polarization speckle in skin cancer detection and monitoring. In O. V. Angelsky (Ed.), Thirteenth International Conference on Correlation Optics [106121B] (Proceedings of SPIE; Vol. 10612). SPIE. https://doi.org/10.1117/12.2305383