Antipyrine estimations in the rabbit using gas-liquid chromatography: A reliable method for studying factors affecting oxidative drug metabolism

D M Chambers; Gordon C Jefferson

doi:10.1016/0160-5402(81)90103-0

Antipyrine estimations in the rabbit using gas-liquid chromatography: A reliable method for studying factors affecting oxidative drug metabolism

D M Chambers, Gordon C Jefferson

School of Engineering & Physical Sciences

Research output: Contribution to journal › Article

Abstract

The application of a gas-liquid chromatographic (GLC) method to measurements of antipyrine in plasma for the estimation of antipyrine half-life (T 1/2 ) in the rabbit is described and is compared with previous GLC methods. It has been established that the estimation of antipyrine can be achieved with acceptable precision and that rabbits can act as their own controls in the study of factors that might alter T( 1/2 ). Iproniazid phosphate, 50 mg/kg IP, was shown to produce a mean increase of 170% in T( 1/2 ).

Original language	English
Pages (from-to)	59-66
Number of pages	8
Journal	Journal of Pharmacological Methods
Volume	5
Issue number	1
DOIs	https://doi.org/10.1016/0160-5402(81)90103-0
Publication status	Published - 1981

Access to Document

10.1016/0160-5402(81)90103-0

Link to publication in Scopus

Fingerprint Dive into the research topics of 'Antipyrine estimations in the rabbit using gas-liquid chromatography: A reliable method for studying factors affecting oxidative drug metabolism'. Together they form a unique fingerprint.

Cite this

@article{6ce9fc59ec6a4056bce5e7352533c5fc,

title = "Antipyrine estimations in the rabbit using gas-liquid chromatography: A reliable method for studying factors affecting oxidative drug metabolism",

abstract = "The application of a gas-liquid chromatographic (GLC) method to measurements of antipyrine in plasma for the estimation of antipyrine half-life (T 1/2 ) in the rabbit is described and is compared with previous GLC methods. It has been established that the estimation of antipyrine can be achieved with acceptable precision and that rabbits can act as their own controls in the study of factors that might alter T( 1/2 ). Iproniazid phosphate, 50 mg/kg IP, was shown to produce a mean increase of 170% in T( 1/2 ).",

author = "Chambers, {D M} and Jefferson, {Gordon C}",

year = "1981",

doi = "10.1016/0160-5402(81)90103-0",

language = "English",

volume = "5",

pages = "59--66",

journal = "Journal of Pharmacological Methods",

issn = "0160-5402",

publisher = "Elsevier",

number = "1",

}

TY - JOUR

T1 - Antipyrine estimations in the rabbit using gas-liquid chromatography

T2 - A reliable method for studying factors affecting oxidative drug metabolism

AU - Chambers, D M

AU - Jefferson, Gordon C

PY - 1981

Y1 - 1981

N2 - The application of a gas-liquid chromatographic (GLC) method to measurements of antipyrine in plasma for the estimation of antipyrine half-life (T 1/2 ) in the rabbit is described and is compared with previous GLC methods. It has been established that the estimation of antipyrine can be achieved with acceptable precision and that rabbits can act as their own controls in the study of factors that might alter T( 1/2 ). Iproniazid phosphate, 50 mg/kg IP, was shown to produce a mean increase of 170% in T( 1/2 ).

AB - The application of a gas-liquid chromatographic (GLC) method to measurements of antipyrine in plasma for the estimation of antipyrine half-life (T 1/2 ) in the rabbit is described and is compared with previous GLC methods. It has been established that the estimation of antipyrine can be achieved with acceptable precision and that rabbits can act as their own controls in the study of factors that might alter T( 1/2 ). Iproniazid phosphate, 50 mg/kg IP, was shown to produce a mean increase of 170% in T( 1/2 ).

UR - http://www.scopus.com/inward/record.url?scp=0019508669&partnerID=8YFLogxK

U2 - 10.1016/0160-5402(81)90103-0

DO - 10.1016/0160-5402(81)90103-0

M3 - Article

VL - 5

SP - 59

EP - 66

JO - Journal of Pharmacological Methods

JF - Journal of Pharmacological Methods

SN - 0160-5402

IS - 1

ER -