Abstract
A 'low-dose' combined oral contraceptive steroid (OCS) preparation containing 30 µg ethinyloestradiol and 150 µg levonorgestrel was found to reduce significantly antipyrine clearance in a group of women acting as their own controls. An OCS preparation containing only a progestogen (75 µg norgestrel) did not reduce antipyrine clearance in a second group of women. The evidence suggesting that the oestrogen component of combined OCS preparations could be responsible for the reduction in antipyrine clearance is discussed.
Original language | English |
---|---|
Pages (from-to) | 229-232 |
Number of pages | 4 |
Journal | British Journal of Clinical Pharmacology |
Volume | 13 |
Issue number | 2 |
Publication status | Published - 1982 |