Antipyrine elimination in saliva after low-dose combined or progestogen-only oral contraceptive steroids

D M Chambers; Gordon C Jefferson; M. Chambers; N. B. Loudon

Antipyrine elimination in saliva after low-dose combined or progestogen-only oral contraceptive steroids

D M Chambers, Gordon C Jefferson, M. Chambers, N. B. Loudon

School of Engineering & Physical Sciences

Research output: Contribution to journal › Article › peer-review

12 Citations (Scopus)

Abstract

A 'low-dose' combined oral contraceptive steroid (OCS) preparation containing 30 µg ethinyloestradiol and 150 µg levonorgestrel was found to reduce significantly antipyrine clearance in a group of women acting as their own controls. An OCS preparation containing only a progestogen (75 µg norgestrel) did not reduce antipyrine clearance in a second group of women. The evidence suggesting that the oestrogen component of combined OCS preparations could be responsible for the reduction in antipyrine clearance is discussed.

Original language	English
Pages (from-to)	229-232
Number of pages	4
Journal	British Journal of Clinical Pharmacology
Volume	13
Issue number	2
Publication status	Published - 1982

Cite this

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title = "Antipyrine elimination in saliva after low-dose combined or progestogen-only oral contraceptive steroids",

abstract = "A 'low-dose' combined oral contraceptive steroid (OCS) preparation containing 30 µg ethinyloestradiol and 150 µg levonorgestrel was found to reduce significantly antipyrine clearance in a group of women acting as their own controls. An OCS preparation containing only a progestogen (75 µg norgestrel) did not reduce antipyrine clearance in a second group of women. The evidence suggesting that the oestrogen component of combined OCS preparations could be responsible for the reduction in antipyrine clearance is discussed.",

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year = "1982",

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AU - Chambers, D M

AU - Jefferson, Gordon C

AU - Chambers, M.

AU - Loudon, N. B.

PY - 1982

Y1 - 1982

N2 - A 'low-dose' combined oral contraceptive steroid (OCS) preparation containing 30 µg ethinyloestradiol and 150 µg levonorgestrel was found to reduce significantly antipyrine clearance in a group of women acting as their own controls. An OCS preparation containing only a progestogen (75 µg norgestrel) did not reduce antipyrine clearance in a second group of women. The evidence suggesting that the oestrogen component of combined OCS preparations could be responsible for the reduction in antipyrine clearance is discussed.

AB - A 'low-dose' combined oral contraceptive steroid (OCS) preparation containing 30 µg ethinyloestradiol and 150 µg levonorgestrel was found to reduce significantly antipyrine clearance in a group of women acting as their own controls. An OCS preparation containing only a progestogen (75 µg norgestrel) did not reduce antipyrine clearance in a second group of women. The evidence suggesting that the oestrogen component of combined OCS preparations could be responsible for the reduction in antipyrine clearance is discussed.

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M3 - Article

SN - 0306-5251

VL - 13

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EP - 232

JO - British Journal of Clinical Pharmacology

JF - British Journal of Clinical Pharmacology

IS - 2

ER -

Antipyrine elimination in saliva after low-dose combined or progestogen-only oral contraceptive steroids

Abstract

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