Anticancer and antifungal activity of copper(II) complexes of quinolin-2(1H)-one-derived Schiff bases

Bernadette S. Creaven, Brian Duff, Denise A. Egan, Kevin Kavanagh, Georgina Rosair, Venkat Reddy Thangella, Maureen Walsh

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119 Citations (Scopus)

Abstract

The condensation of substituted aromatic aldehydes with 7-amino-4-methyl-quinolin-2(1H)-one (1) has lead to the isolation of quinolin-2(1H)-one derived Schiff bases (2-14). The copper(II) complexes (2a-14a) of the ligands were also prepared, and together with their corresponding free ligands were fully characterised by elemental analyses, spectral methods (IR, 1H and 13C NMR, AAS, UV-Vis), magnetic and conductance measurements. The bidentate ligands coordinated to the copper(II) ion through the deprotonated phenolic oxygen and the azomethine nitrogen of the ligands in almost all cases. X-ray crystal structures of two of the complexes, 5a and 8a, confirmed the bidentate coordination mode. All of the compounds were investigated for their antimicrobial activities against the fungus, Candida albicans, and against Gram-positive and Gram-negative bacteria. The compounds were found to have excellent anti-Candida activity but were inactive against Staphylococcus aureus and Escherichia coli. Selected compounds (2-8 and 2a-8a) were also screened for their in vitro anticancer potential using the human hepatic carcinoma cell line, Hep-G2. Several derivatives were shown to be active comparable to that of cisplatin. © 2010 Elsevier B.V. All rights reserved.

Original languageEnglish
Pages (from-to)4048-4058
Number of pages11
JournalInorganica Chimica Acta
Volume363
Issue number14
DOIs
Publication statusPublished - 25 Nov 2010

Keywords

  • Biological activity
  • Copper(II) complexes
  • Quinolin-2(1H)-one
  • Schiff bases
  • X-ray structures

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    Creaven, B. S., Duff, B., Egan, D. A., Kavanagh, K., Rosair, G., Thangella, V. R., & Walsh, M. (2010). Anticancer and antifungal activity of copper(II) complexes of quinolin-2(1H)-one-derived Schiff bases. Inorganica Chimica Acta, 363(14), 4048-4058. https://doi.org/10.1016/j.ica.2010.08.009