TY - JOUR
T1 - Antibody producing cells in the spleens of mice treated with pathogenic mineral dust
AU - Szymaniec, S.
AU - Brown, D. M.
AU - Chladzynska, M.
AU - Jankowska, E.
AU - Polikowska, H.
AU - Donaldson, K.
PY - 1989
Y1 - 1989
N2 - Experiments were carried out to assess the effect of intraperitoneal injection of the mineral dusts, titanium dioxide, quartz, or asbestos, on splenic lymphocyte antibody forming cells in immunised mice. Titanium dioxide and quartz caused similar, about one third, reductions in plaque forming cells; asbestos caused substantial reduction to about a quarter of the number found in control spleens. The inhibition of antibody forming cells in the spleen found with chrysotile was dose dependent and both chrysotile and crocidolite asbestos were similar in activity. Systemic immunomodulation after local deposition of mineral dust may be important to the development of disease.
AB - Experiments were carried out to assess the effect of intraperitoneal injection of the mineral dusts, titanium dioxide, quartz, or asbestos, on splenic lymphocyte antibody forming cells in immunised mice. Titanium dioxide and quartz caused similar, about one third, reductions in plaque forming cells; asbestos caused substantial reduction to about a quarter of the number found in control spleens. The inhibition of antibody forming cells in the spleen found with chrysotile was dose dependent and both chrysotile and crocidolite asbestos were similar in activity. Systemic immunomodulation after local deposition of mineral dust may be important to the development of disease.
UR - http://www.scopus.com/inward/record.url?scp=0024419996&partnerID=8YFLogxK
U2 - 10.1136/oem.46.10.724
DO - 10.1136/oem.46.10.724
M3 - Article
C2 - 2554954
AN - SCOPUS:0024419996
SN - 0007-1072
VL - 46
SP - 724
EP - 728
JO - British Journal of Industrial Medicine
JF - British Journal of Industrial Medicine
IS - 10
ER -
