Analytical Study of a Magnetophoretic Microdevice as a Potential Enrichment Step in the Isolation of Nucleated Red Blood Cells from Maternal Blood

Giuseppe Schiavone; Deirdre Kavanagh; Marc Phillipe Yves Desmulliez

Analytical Study of a Magnetophoretic Microdevice as a Potential Enrichment Step in the Isolation of Nucleated Red Blood Cells from Maternal Blood

Giuseppe Schiavone, Deirdre Kavanagh, Marc Phillipe Yves Desmulliez

Research output: Contribution to journal › Article › peer-review

Abstract

The design and simulation of a microscale magnetophoretic separator is presented, as part of a lab-on-chip module for non-invasive prenatal diagnosis (NIPD). The separation of fetal cells and cell free fetal DNA from maternal blood with great reproducibility and efficiency is still beyond the reach of commonly used techniques. This magnetophoretic separator is used to enhance the efficiency of the separation. The work presented here focuses on the modelling and simulation of a novel technique for the separation of fetal nucleated red blood cells (NRBCs) from the maternal circulation based on the intrinsic magnetic properties of these cells.

Original language	English
Pages (from-to)	246-250
Journal	International Review of Chemical Engineering
Volume	2
Issue number	2
Publication status	Published - Mar 2010

Keywords

NIPD
MEMs
Magnetophoresis
Lab-On-Chip
Prenatal diagnosis

Cite this

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abstract = "The design and simulation of a microscale magnetophoretic separator is presented, as part of a lab-on-chip module for non-invasive prenatal diagnosis (NIPD). The separation of fetal cells and cell free fetal DNA from maternal blood with great reproducibility and efficiency is still beyond the reach of commonly used techniques. This magnetophoretic separator is used to enhance the efficiency of the separation. The work presented here focuses on the modelling and simulation of a novel technique for the separation of fetal nucleated red blood cells (NRBCs) from the maternal circulation based on the intrinsic magnetic properties of these cells.",

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Analytical Study of a Magnetophoretic Microdevice as a Potential Enrichment Step in the Isolation of Nucleated Red Blood Cells from Maternal Blood. / Schiavone, Giuseppe; Kavanagh, Deirdre; Desmulliez, Marc Phillipe Yves.
In: International Review of Chemical Engineering , Vol. 2, No. 2, 03.2010, p. 246-250.

Research output: Contribution to journal › Article › peer-review

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KW - Magnetophoresis

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Analytical Study of a Magnetophoretic Microdevice as a Potential Enrichment Step in the Isolation of Nucleated Red Blood Cells from Maternal Blood

Abstract

Keywords

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