Analytical Study of a Magnetophoretic Microdevice as a Potential Enrichment Step in the Isolation of Nucleated Red Blood Cells from Maternal Blood

Giuseppe Schiavone, Deirdre Kavanagh, Marc Phillipe Yves Desmulliez

Research output: Contribution to journalArticle

Abstract

The design and simulation of a microscale magnetophoretic separator is presented, as part of a lab-on-chip module for non-invasive prenatal diagnosis (NIPD). The separation of fetal cells and cell free fetal DNA from maternal blood with great reproducibility and efficiency is still beyond the reach of commonly used techniques. This magnetophoretic separator is used to enhance the efficiency of the separation. The work presented here focuses on the modelling and simulation of a novel technique for the separation of fetal nucleated red blood cells (NRBCs) from the maternal circulation based on the intrinsic magnetic properties of these cells.
Original languageEnglish
Pages (from-to)246-250
JournalInternational Review of Chemical Engineering
Volume2
Issue number2
Publication statusPublished - Mar 2010

Keywords

  • NIPD
  • MEMs
  • Magnetophoresis
  • Lab-On-Chip
  • Prenatal diagnosis

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