The presence of heavy metal ions in the biosphere is of grave concern, as these are toxic and impact living organisms. Lack of pure drinking water can spread waterborne diseases like cholera, dysentery, typhoid, etc. The presence of heavy metals like arsenic and radioactive materials can cause cancer. The detection and removal of these heavy metals are important for sustaining life. Herein, MXene comes to the rescue as a crucial and potential material, which can sense and adsorb heavy metal ions. Developed in 2011, MXenes are an emerging class of 2D nanomaterials that are appropriate substitutes for existing heavy metal ions sensing materials and have shown excellent efficiency due to their better hydrophilicity, capacity of transportation of electrons, functionalization, and a great variety in compositions as compared to the other nanomaterials properties. This work gives an insight into the chemistry and synthesis of MXenes for further utilization as a sensor in heavy metal ions toxicity and underlines the key future challenges to knowing the full prospective of MXenes in environmental systems.