Analysis of finite dose dermal absorption data: Implications for dermal exposure assessment

H. Frederick Frasch, G. Scott Dotson, Annette L. Bunge, Chen Peng Chen, John W. Cherrie, Gerald B. Kasting, John C. Kissel, Jennifer Sahmel, Sean Semple, Simon Wilkinson

    Research output: Contribution to journalArticle

    36 Citations (Scopus)

    Abstract

    A common dermal exposure assessment strategy estimates the systemic uptake of chemical in contact with skin using the fixed fractional absorption approach: the dermal absorbed dose is estimated as the product of exposure and the fraction of applied chemical that is absorbed, assumed constant for a given chemical. Despite the prominence of this approach there is little guidance regarding the evaluation of experiments from which fractional absorption data are measured. An analysis of these experiments is presented herein, and limitations to the fixed fractional absorption approach are discussed. The analysis provides a set of simple algebraic expressions that may be used in the evaluation of finite dose dermal absorption experiments, affording a more data-driven approach to dermal exposure assessment. Case studies are presented that demonstrate the application of these tools to the assessment of dermal absorption data.

    Original languageEnglish
    Pages (from-to)65-73
    Number of pages9
    JournalJournal of Exposure Science and Environmental Epidemiology
    Volume24
    Issue number1
    DOIs
    Publication statusPublished - 2014

    Keywords

    • Dermal load
    • Evaporation
    • Fractional absorption
    • Maximum flux
    • Percent absorption
    • Risk assessment
    • Skin absorption

    ASJC Scopus subject areas

    • Pollution
    • Public Health, Environmental and Occupational Health
    • Toxicology
    • Epidemiology

    Fingerprint Dive into the research topics of 'Analysis of finite dose dermal absorption data: Implications for dermal exposure assessment'. Together they form a unique fingerprint.

  • Cite this

    Frasch, H. F., Dotson, G. S., Bunge, A. L., Chen, C. P., Cherrie, J. W., Kasting, G. B., Kissel, J. C., Sahmel, J., Semple, S., & Wilkinson, S. (2014). Analysis of finite dose dermal absorption data: Implications for dermal exposure assessment. Journal of Exposure Science and Environmental Epidemiology, 24(1), 65-73. https://doi.org/10.1038/jes.2013.23