An Organ Flow Model for Developing Vascular Characterization Using Contrast Enhanced Ultrasound (CEUS) Imaging

Vasiliki Voulgaridou, Steven McDougall, Ahmed Boujelben, Mairead Butler, Konstantinos Diamantis, Vassilis Sboros

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Whilst the detection of structural and dynamic variations in small blood vessels could aid the early detection of a large number of non-communicable diseases, current imaging methods do not provide reliable measurements of such changes. A realistic Small Vessel Vascular Bed (SVVB) model is presented here that can address microvascular changes and flow-redistribution related to such diseases. The location of abnormal structures within the SVVB may result in varying degrees of flow redistribution, which can have a different impact on CEUS images. In a series of in silico experiments, the SVVB was traversed by MB bolus injections and CEUS parametric mapping was used to detect regions of abnormal perfusion. In general, it was shown that alterations to the flow in the SVVB were reflected in parametric maps but the dynamic adaptation of the flow presents a significant challenge for CEUS measurements. Specifically, the flow redistribution, which is highly significant when areas around the main flow path are affected, is not possible to quantify or assess with CEUS. Thus, the differentiation of abnormal vascular patterns from normal ones becomes problematic with conventional CEUS quantification approaches.
Original languageEnglish
Title of host publication2020 IEEE International Ultrasonics Symposium (IUS)
PublisherIEEE
ISBN (Electronic)9781728154480
DOIs
Publication statusPublished - 17 Nov 2020
Event2020 IEEE International Ultrasonics Symposium - Las Vegas, United States
Duration: 7 Sep 202011 Sep 2020

Publication series

NameIEEE International Ultrasonics Symposium (IUS)
ISSN (Electronic)1948-5727

Conference

Conference2020 IEEE International Ultrasonics Symposium
Abbreviated titleIUS 2020
CountryUnited States
CityLas Vegas
Period7/09/2011/09/20

Keywords

  • Flow
  • Flow-imaging
  • Medical imaging
  • Microbubble-contrast-agents
  • Parametric map

ASJC Scopus subject areas

  • Acoustics and Ultrasonics

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