An investigation into the role of synaptic vesicular Mg++-ATPase in neurotransmitter release, using benzhydryl piperazines

M. G. Wyllie, John C Gilbert

    Research output: Contribution to journalArticle

    Abstract

    A series of benzhydryl piperazines was found to inhibit synaptic vesicular Mg++-ATPase. These compounds were also found to increase basal and evoked release of noradrenaline from synaptosomes. A comparison was made between the concentrations effective in inhibiting the enzyme and promoting noradrenaline release. In general, as the degree of Mg++-ATPase inhibition increased, noradrenaline release was increased. The relevance of these findings to a possible role of Mg++-ATPase in noradrenaline release is discussed.

    Original languageEnglish
    Pages (from-to)4-15
    Number of pages12
    JournalArchives Internationales de Pharmacodynamie et de Thérapie
    Volume241
    Issue number1
    Publication statusPublished - 1979

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