An in-situ synchrotron X-ray diffraction tomography study of crystallization and preferred crystal orientation in a stirred reactor

S. D. M. Jacques; K. Pile; P. Barnes; X. Lai; K. J. Roberts; Richard A Williams

doi:10.1021/cg0497288

An in-situ synchrotron X-ray diffraction tomography study of crystallization and preferred crystal orientation in a stirred reactor

S. D. M. Jacques, K. Pile, P. Barnes, X. Lai, K. J. Roberts, Richard A Williams

School of Engineering & Physical Sciences

Research output: Contribution to journal › Article › peer-review

22 Citations (Scopus)

Abstract

A new tomographic technique, based on synchrotron X-ray diffraction, has been used to chart polymorphic content and crystallite alignment inside a model pharmaceutical reactor. This reveals complex behavior according to
crystallite shape/size characteristics; in particular, stirring induces pronounced crystal zonation marked by a boundary “alignment band” in which the crystallites adopt a “stand on edge” orientation.

Original language	English
Pages (from-to)	395-397
Number of pages	3
Journal	Crystal Growth and Design
Volume	5
Issue number	2
DOIs	https://doi.org/10.1021/cg0497288
Publication status	Published - 2005

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title = "An in-situ synchrotron X-ray diffraction tomography study of crystallization and preferred crystal orientation in a stirred reactor",

abstract = "A new tomographic technique, based on synchrotron X-ray diffraction, has been used to chart polymorphic content and crystallite alignment inside a model pharmaceutical reactor. This reveals complex behavior according tocrystallite shape/size characteristics; in particular, stirring induces pronounced crystal zonation marked by a boundary “alignment band” in which the crystallites adopt a “stand on edge” orientation.",

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AU - Jacques, S. D. M.

AU - Pile, K.

AU - Barnes, P.

AU - Lai, X.

AU - Roberts, K. J.

AU - Williams, Richard A

PY - 2005

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AB - A new tomographic technique, based on synchrotron X-ray diffraction, has been used to chart polymorphic content and crystallite alignment inside a model pharmaceutical reactor. This reveals complex behavior according tocrystallite shape/size characteristics; in particular, stirring induces pronounced crystal zonation marked by a boundary “alignment band” in which the crystallites adopt a “stand on edge” orientation.

U2 - 10.1021/cg0497288

DO - 10.1021/cg0497288

M3 - Article

SN - 1528-7483

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SP - 395

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JO - Crystal Growth and Design

JF - Crystal Growth and Design

IS - 2

ER -

An in-situ synchrotron X-ray diffraction tomography study of crystallization and preferred crystal orientation in a stirred reactor

Abstract

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