TY - JOUR
T1 - An extract from teak (Tectona grandis) bark inhibited Listeria monocytogenes and methicillin resistant Staphylococcus aureus
AU - Neamatallah, A.
AU - Yan, L.
AU - Dewar, S. J.
AU - Austin, B.
PY - 2005
Y1 - 2005
N2 - Aims: The aim of this study was to characterize the inhibitory mechanism in teak (Tectona grandis) bark and to determine its effectiveness against Listeria monocytogenes and methicillin resistant Staphylococcus aureus (MRSA). Methods and Results: Methanol extracts of teak bark were inhibitory to L. monocytogenes and MRSA by means of disc diffusion. Gas chromatography-mass spectrometry, and 1H and 3C nuclear mass resonance analyses revealed that the inhibitory compound had a molecular weight of 174, and a structure of 5-hydroxy-1,4-naphthalenedione (Juglone). Conclusions: 5-hydroxy-1,4- naphthalenedione (Juglone) inhibited L. monocytogenes and MRSA. Significance and Impact of the Study: A compound in an extract of teak bark was inhibitory to L. monocytogenes and MRSA. © 2005 The Society for Applied Microbiology.
AB - Aims: The aim of this study was to characterize the inhibitory mechanism in teak (Tectona grandis) bark and to determine its effectiveness against Listeria monocytogenes and methicillin resistant Staphylococcus aureus (MRSA). Methods and Results: Methanol extracts of teak bark were inhibitory to L. monocytogenes and MRSA by means of disc diffusion. Gas chromatography-mass spectrometry, and 1H and 3C nuclear mass resonance analyses revealed that the inhibitory compound had a molecular weight of 174, and a structure of 5-hydroxy-1,4-naphthalenedione (Juglone). Conclusions: 5-hydroxy-1,4- naphthalenedione (Juglone) inhibited L. monocytogenes and MRSA. Significance and Impact of the Study: A compound in an extract of teak bark was inhibitory to L. monocytogenes and MRSA. © 2005 The Society for Applied Microbiology.
KW - 5-hydroxy-1,4-naphthalenedione
KW - Antibacterial activity
KW - Juglone
KW - Listeria monocytogenes
KW - Staphylococcus aureus
KW - Teak (Tectona grandis)
UR - http://www.scopus.com/inward/record.url?scp=21344454273&partnerID=8YFLogxK
U2 - 10.1111/j.1472-765X.2005.01680.x
DO - 10.1111/j.1472-765X.2005.01680.x
M3 - Article
C2 - 15960759
SN - 1472-765X
VL - 41
SP - 94
EP - 96
JO - Letters in Applied Microbiology
JF - Letters in Applied Microbiology
IS - 1
ER -