Amino acid activation of 3-phosphoglycerate dehydrogenase from peas

J. Colin Slaughter

    Research output: Contribution to journalArticlepeer-review

    1 Citation (Scopus)


    When l-methionine was added to an extract of etiolated pea epicotyls activation of 3-phosphoglycerate dehydrogenase occurred and was complete in 20-30 min. Storage of extracts at 5° led to a loss in the ability of l-methionine to activate the enzyme and after 24 hr storage almost no activation was observed. On the basis of tests with 16 compounds the ability to activate 3-phosphoglycerate dehydrogenase was restricted to l-amino acids with intermediate-length side chains. There appears to be no requirement for a reactive group in the side chain. Gel-filtration showed that the higher levels of 3-phosphoglycerate dehydrogenase activity obtained after treatment with l-methionine are relatively stable. © 1975.

    Original languageEnglish
    Pages (from-to)1711-1713
    Number of pages3
    Issue number8
    Publication statusPublished - Aug 1975


    • 3-phosphoglycerate dehydrogenase
    • allosteric activation
    • Leguminosae
    • methionine.
    • pea
    • Pisum sativum


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