Advantages of synthesizing trans-1,2-cyclohexanediol in a continuous flow microreactor over a standard glass apparatus

Andreas Hartung, Mark A. Keane, Arno Kraft

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

(Figure Presented) Comparison is made between the preparation of trans-1,2-cyclohexanediol in standard glassware (conventional batch production) and in a microreactor (continuous flow production). The reaction sequence involved two exothermic steps where the standard procedure demands slow reagent addition and careful temperature control. In the microreactor, the reaction could be carried out safely with up to 3 times higher reagent concentration. Synthetic benefits were a faster reaction rate and a higher purity product free of colored impurities (a feature of the batch procedure). © 2007 American Chemical Society.

Original languageEnglish
Pages (from-to)10235-10238
Number of pages4
JournalJournal of Organic Chemistry
Volume72
Issue number26
DOIs
Publication statusPublished - 21 Dec 2007

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