Advances in photoacoustic noninvasive glucose testing

Hugh A. MacKenzie, Helen S. Ashton, Stephen Spiers, Yaochun Shen, Scott S. Freeborn, John Hannigan, John Lindberg, Peter Rae

Research output: Contribution to journalArticlepeer-review

267 Citations (Scopus)


We report here on in vitro and in vivo experiments that are intended to explore the feasibility of photoacoustic spectroscopy as a tool for the noninvasive measurement of blood glucose. The in vivo results from oral glucose tests on eight subjects showed good correlation with clinical measurements but indicated that physiological factors and person-to-person variability are important. In vitro measurements showed that the sensitivity of the glucose measurement is unaffected by the presence of common blood analytes but that there can be substantial shifts in baseline values. The results indicate the need for spectroscopic data to develop algorithms for the detection of glucose in the presence of other analytes.

Original languageEnglish
Pages (from-to)1587-1595
Number of pages9
JournalClinical Chemistry
Issue number9
Publication statusPublished - 1999
EventClinical Chemistry -
Duration: 1 Jan 1999 → …


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