Advanced reach tool (ART): Development of the mechanistic model

Wouter Fransman*, Martie Van Tongeren, John W. Cherrie, Martin Tischer, Thomas Schneider, Jody Schinkel, Hans Kromhout, Nick Warren, Henk Goede, Erik Tielemans

*Corresponding author for this work

    Research output: Contribution to journalArticlepeer-review

    85 Citations (Scopus)


    This paper describes the development of the mechanistic model within a collaborative project, referred to as the Advanced REACH Tool (ART) project, to develop a tool to model inhalation exposure for workers sharing similar operational conditions across different industries and locations in Europe. The ART mechanistic model is based on a conceptual framework that adopts a source receptor approach, which describes the transport of a contaminant from the source to the receptor and defines seven independent principal modifying factors: substance emission potential, activity emission potential, localized controls, segregation, personal enclosure, surface contamination, and dispersion. ART currently differentiates between three different exposure types: vapours, mists, and dust (fumes, fibres, and gases are presently excluded). Various sources were used to assign numerical values to the multipliers to each modifying factor. The evidence used to underpin this assessment procedure was based on chemical and physical laws. In addition, empirical data obtained from literature were used. Where this was not possible, expert elicitation was applied for the assessment procedure. Multipliers for all modifying factors were peer reviewed by leading experts from industry, research institutes, and public authorities across the globe. In addition, several workshops with experts were organized to discuss the proposed exposure multipliers. The mechanistic model is a central part of the ART tool and with advancing knowledge on exposure, determinants will require updates and refinements on a continuous basis, such as the effect of worker behaviour on personal exposure, 'best practice' values that describe the maximum achievable effectiveness of control measures, the intrinsic emission potential of various solid objects (e.g. metal, glass, plastics, etc.), and extending the applicability domain to certain types of exposures (e.g. gas, fume, and fibre exposure).

    Original languageEnglish
    Pages (from-to)957-979
    Number of pages23
    JournalAnnals of Occupational Hygiene
    Issue number9
    Publication statusPublished - Nov 2011


    • determinants of exposure
    • expert judgement
    • exposure assessment
    • exposure modeling
    • mechanistic model
    • occupational exposure

    ASJC Scopus subject areas

    • Public Health, Environmental and Occupational Health


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