Abstract
Additive manufacturing techniques offer the potential to fabricate organized tissue constructs to repair or replace damaged or diseased human tissues and organs. Using these techniques, spatial variations of cells along multiple axes with high geometric complexity in combination with different biomaterials can be generated. The level of control offered by these computer-controlled technologies to design and fabricate tissues will accelerate our understanding of the governing factors of tissue formation and function. Moreover, it will provide a valuable tool to study the effect of anatomy on graft performance. In this review, we discuss the rationale for engineering tissues and organs by combining computer-aided design with additive manufacturing technologies that encompass the simultaneous deposition of cells and materials. Current strategies are presented, particularly with respect to limitations due to the lack of suitable polymers, and requirements to move the current concepts to practical application. (C) 2011 Elsevier Ltd. All rights reserved.
| Original language | English |
|---|---|
| Pages (from-to) | 1079-1104 |
| Number of pages | 26 |
| Journal | Progress in Polymer Science |
| Volume | 37 |
| Issue number | 8 |
| DOIs | |
| Publication status | Published - Aug 2012 |
Keywords
- Additive manufacturing
- Bioprinting
- Biofabrication
- Hydrogels
- Tissue engineering
- RAPID PROTOTYPING TECHNIQUES
- CELL SHEET DETACHMENT
- OF-THE-ART
- ENGINEERING SCAFFOLDS
- REGENERATIVE MEDICINE
- HYALURONIC-ACID
- IN-VITRO
- MECHANICAL-PROPERTIES
- BIODEGRADABLE SCAFFOLDS
- PEG HYDROGELS
Cite this
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Additive manufacturing of tissues and organs. / Melchels, Ferry P. W.; Domingos, Marco A. N.; Klein, Travis J.; Malda, Jos; Bartolo, Paulo J.; Hutmacher, Dietmar W.
In: Progress in Polymer Science, Vol. 37, No. 8, 08.2012, p. 1079-1104.Research output: Contribution to journal › Literature review
TY - JOUR
T1 - Additive manufacturing of tissues and organs
AU - Melchels, Ferry P. W.
AU - Domingos, Marco A. N.
AU - Klein, Travis J.
AU - Malda, Jos
AU - Bartolo, Paulo J.
AU - Hutmacher, Dietmar W.
PY - 2012/8
Y1 - 2012/8
N2 - Additive manufacturing techniques offer the potential to fabricate organized tissue constructs to repair or replace damaged or diseased human tissues and organs. Using these techniques, spatial variations of cells along multiple axes with high geometric complexity in combination with different biomaterials can be generated. The level of control offered by these computer-controlled technologies to design and fabricate tissues will accelerate our understanding of the governing factors of tissue formation and function. Moreover, it will provide a valuable tool to study the effect of anatomy on graft performance. In this review, we discuss the rationale for engineering tissues and organs by combining computer-aided design with additive manufacturing technologies that encompass the simultaneous deposition of cells and materials. Current strategies are presented, particularly with respect to limitations due to the lack of suitable polymers, and requirements to move the current concepts to practical application. (C) 2011 Elsevier Ltd. All rights reserved.
AB - Additive manufacturing techniques offer the potential to fabricate organized tissue constructs to repair or replace damaged or diseased human tissues and organs. Using these techniques, spatial variations of cells along multiple axes with high geometric complexity in combination with different biomaterials can be generated. The level of control offered by these computer-controlled technologies to design and fabricate tissues will accelerate our understanding of the governing factors of tissue formation and function. Moreover, it will provide a valuable tool to study the effect of anatomy on graft performance. In this review, we discuss the rationale for engineering tissues and organs by combining computer-aided design with additive manufacturing technologies that encompass the simultaneous deposition of cells and materials. Current strategies are presented, particularly with respect to limitations due to the lack of suitable polymers, and requirements to move the current concepts to practical application. (C) 2011 Elsevier Ltd. All rights reserved.
KW - Additive manufacturing
KW - Bioprinting
KW - Biofabrication
KW - Hydrogels
KW - Tissue engineering
KW - RAPID PROTOTYPING TECHNIQUES
KW - CELL SHEET DETACHMENT
KW - OF-THE-ART
KW - ENGINEERING SCAFFOLDS
KW - REGENERATIVE MEDICINE
KW - HYALURONIC-ACID
KW - IN-VITRO
KW - MECHANICAL-PROPERTIES
KW - BIODEGRADABLE SCAFFOLDS
KW - PEG HYDROGELS
U2 - 10.1016/j.progpolymsci.2011.11.007
DO - 10.1016/j.progpolymsci.2011.11.007
M3 - Literature review
VL - 37
SP - 1079
EP - 1104
JO - Progress in Polymer Science
JF - Progress in Polymer Science
SN - 0079-6700
IS - 8
ER -