A transcultural cognitive marker of Alzheimer’s Disease

Sergio Della Sala, Irina Kozlova, Andreea Stamate, Mario Parra Rodriguez

Research output: Contribution to journalArticle

Abstract

Objective: Temporary binding (TB) is sensitive and specific to Alzheimer’s Disease (AD), is not affected by age, repeated testing or level of education. Hence, TB is useful to assess patients with very different socio-cultural backgrounds. However, the current computerised version of the test is not suitable for use in clinical settings. The aim of this study was to investigate whether a clinically friendly version of the TB task results in overlapping outcomes compared to the computerised version. Methods: A newly devised Flash-card version of the TB assesses temporary visual binding for arrays of
stimuli such as shapes (polygons), colours, or combinations of shapes and colours. In Experiment 1, this version was compared with the laboratory computerised version. In Experiment 2, 33 AD patients and 33 matched controls, recruited from various geriatric centres in Romania, were assessed with the
new TB test and with Free and Cued Selective Reminding test. Results: The results with the Flash-card version of the TB test were comparable to those obtained with the computerised version. TB was not affected by age, but it was impaired by AD. The sensitivity and specificity of the new TB test were found to be greater than those achieved by a Selective Reminding test. Conclusions: TB deficits may be conceived as a fundamental marker of AD. The Flash-card version is suitable for clinical use also in primary care facilities and in intervention trials, requires minimal training for administration and scoring, is quick to administer, non-invasive, inexpensive, and facilitates cross-cultural studies.
Original languageEnglish
JournalInternational Journal of Geriatric Psychiatry
Early online date2 Nov 2016
DOIs
StateE-pub ahead of print - 2 Nov 2016

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test
Alzheimer Disease
Color
experiment
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Romania
Geriatrics
Primary Health Care
Education
polygon
education
geriatrics
cultural studies
level of education
deficit
stimulus
trial
administration
facility

Cite this

Della Sala, Sergio; Kozlova, Irina; Stamate, Andreea; Parra Rodriguez, Mario / A transcultural cognitive marker of Alzheimer’s Disease.

In: International Journal of Geriatric Psychiatry, 02.11.2016.

Research output: Contribution to journalArticle

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author = "{Della Sala}, Sergio and Irina Kozlova and Andreea Stamate and {Parra Rodriguez}, Mario",
year = "2016",
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doi = "10.1002/gps.4610",
journal = "International Journal of Geriatric Psychiatry",
issn = "0885-6230",
publisher = "John Wiley and Sons Ltd",

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A transcultural cognitive marker of Alzheimer’s Disease. / Della Sala, Sergio; Kozlova, Irina; Stamate, Andreea; Parra Rodriguez, Mario.

In: International Journal of Geriatric Psychiatry, 02.11.2016.

Research output: Contribution to journalArticle

TY - JOUR

T1 - A transcultural cognitive marker of Alzheimer’s Disease

AU - Della Sala,Sergio

AU - Kozlova,Irina

AU - Stamate,Andreea

AU - Parra Rodriguez,Mario

PY - 2016/11/2

Y1 - 2016/11/2

N2 - Objective: Temporary binding (TB) is sensitive and specific to Alzheimer’s Disease (AD), is not affected by age, repeated testing or level of education. Hence, TB is useful to assess patients with very different socio-cultural backgrounds. However, the current computerised version of the test is not suitable for use in clinical settings. The aim of this study was to investigate whether a clinically friendly version of the TB task results in overlapping outcomes compared to the computerised version. Methods: A newly devised Flash-card version of the TB assesses temporary visual binding for arrays ofstimuli such as shapes (polygons), colours, or combinations of shapes and colours. In Experiment 1, this version was compared with the laboratory computerised version. In Experiment 2, 33 AD patients and 33 matched controls, recruited from various geriatric centres in Romania, were assessed with thenew TB test and with Free and Cued Selective Reminding test. Results: The results with the Flash-card version of the TB test were comparable to those obtained with the computerised version. TB was not affected by age, but it was impaired by AD. The sensitivity and specificity of the new TB test were found to be greater than those achieved by a Selective Reminding test. Conclusions: TB deficits may be conceived as a fundamental marker of AD. The Flash-card version is suitable for clinical use also in primary care facilities and in intervention trials, requires minimal training for administration and scoring, is quick to administer, non-invasive, inexpensive, and facilitates cross-cultural studies.

AB - Objective: Temporary binding (TB) is sensitive and specific to Alzheimer’s Disease (AD), is not affected by age, repeated testing or level of education. Hence, TB is useful to assess patients with very different socio-cultural backgrounds. However, the current computerised version of the test is not suitable for use in clinical settings. The aim of this study was to investigate whether a clinically friendly version of the TB task results in overlapping outcomes compared to the computerised version. Methods: A newly devised Flash-card version of the TB assesses temporary visual binding for arrays ofstimuli such as shapes (polygons), colours, or combinations of shapes and colours. In Experiment 1, this version was compared with the laboratory computerised version. In Experiment 2, 33 AD patients and 33 matched controls, recruited from various geriatric centres in Romania, were assessed with thenew TB test and with Free and Cued Selective Reminding test. Results: The results with the Flash-card version of the TB test were comparable to those obtained with the computerised version. TB was not affected by age, but it was impaired by AD. The sensitivity and specificity of the new TB test were found to be greater than those achieved by a Selective Reminding test. Conclusions: TB deficits may be conceived as a fundamental marker of AD. The Flash-card version is suitable for clinical use also in primary care facilities and in intervention trials, requires minimal training for administration and scoring, is quick to administer, non-invasive, inexpensive, and facilitates cross-cultural studies.

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T2 - International Journal of Geriatric Psychiatry

JF - International Journal of Geriatric Psychiatry

SN - 0885-6230

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