A total asymmetric synthesis of (-)-suaveoline

Patrick D. Bailey, Keith M. Morgan

Research output: Contribution to journalArticlepeer-review

21 Citations (Scopus)


A new total synthesis of (-)-suaveoline from L-tryptophan is reported (overall yield ca. 14%); key steps include a high yielding cis-specific Pictet-Spengler reaction, a one-pot Horner-Wadsworth-Emmons/alkylation procedure, a vinylogous Thorpe cyclization and the direct formation of a pyridine from a 1,5-dinitrile.

Original languageEnglish
Pages (from-to)1479-1480
Number of pages2
JournalChemical Communications
Issue number12
Publication statusPublished - 1996


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