A single residue change in Vibrio harveyi hemolysin results in the loss of phospholipase and hemolytic activities and pathogenicity for turbot (Scophthalmus maximus)

Boguang Sun; Xiao H. Zhang; Xuexi Tang; Shushan Wang; Yingbin Zhong; Jixiang Chen; Brian Austin

doi:10.1128/JB.01650-06

A single residue change in Vibrio harveyi hemolysin results in the loss of phospholipase and hemolytic activities and pathogenicity for turbot (Scophthalmus maximus)

Boguang Sun, Xiao H. Zhang, Xuexi Tang, Shushan Wang, Yingbin Zhong, Jixiang Chen, Brian Austin

Research output: Contribution to journal › Article › peer-review

47 Citations (Scopus)

Abstract

Vibrio harveyi hemolysin, an important virulence determinant in fish pathogenesis, was further characterized, and the enzyme was identified as a phospholipase B by gas chromatography. Site-directed mutagenesis revealed that a specific residue, Ser153, was critical for its enzymatic activity and for its virulence in fish. Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Original language	English
Pages (from-to)	2575-2579
Number of pages	5
Journal	Journal of Bacteriology
Volume	189
Issue number	6
DOIs	https://doi.org/10.1128/JB.01650-06
Publication status	Published - Mar 2007

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title = "A single residue change in Vibrio harveyi hemolysin results in the loss of phospholipase and hemolytic activities and pathogenicity for turbot (Scophthalmus maximus)",

abstract = "Vibrio harveyi hemolysin, an important virulence determinant in fish pathogenesis, was further characterized, and the enzyme was identified as a phospholipase B by gas chromatography. Site-directed mutagenesis revealed that a specific residue, Ser153, was critical for its enzymatic activity and for its virulence in fish. Copyright {\textcopyright} 2007, American Society for Microbiology. All Rights Reserved.",

author = "Boguang Sun and Zhang, \{Xiao H.\} and Xuexi Tang and Shushan Wang and Yingbin Zhong and Jixiang Chen and Brian Austin",

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AU - Sun, Boguang

AU - Zhang, Xiao H.

AU - Tang, Xuexi

AU - Wang, Shushan

AU - Zhong, Yingbin

AU - Chen, Jixiang

AU - Austin, Brian

PY - 2007/3

Y1 - 2007/3

N2 - Vibrio harveyi hemolysin, an important virulence determinant in fish pathogenesis, was further characterized, and the enzyme was identified as a phospholipase B by gas chromatography. Site-directed mutagenesis revealed that a specific residue, Ser153, was critical for its enzymatic activity and for its virulence in fish. Copyright © 2007, American Society for Microbiology. All Rights Reserved.

AB - Vibrio harveyi hemolysin, an important virulence determinant in fish pathogenesis, was further characterized, and the enzyme was identified as a phospholipase B by gas chromatography. Site-directed mutagenesis revealed that a specific residue, Ser153, was critical for its enzymatic activity and for its virulence in fish. Copyright © 2007, American Society for Microbiology. All Rights Reserved.

UR - https://www.scopus.com/pages/publications/33947098843

U2 - 10.1128/JB.01650-06

DO - 10.1128/JB.01650-06

M3 - Article

SN - 0021-9193

VL - 189

SP - 2575

EP - 2579

JO - Journal of Bacteriology

JF - Journal of Bacteriology

IS - 6

ER -

A single residue change in Vibrio harveyi hemolysin results in the loss of phospholipase and hemolytic activities and pathogenicity for turbot (Scophthalmus maximus)

Abstract

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