A single residue change in Vibrio harveyi hemolysin results in the loss of phospholipase and hemolytic activities and pathogenicity for turbot (Scophthalmus maximus)

Boguang Sun, Xiao H. Zhang, Xuexi Tang, Shushan Wang, Yingbin Zhong, Jixiang Chen, Brian Austin

    Research output: Contribution to journalArticle

    28 Citations (Scopus)

    Abstract

    Vibrio harveyi hemolysin, an important virulence determinant in fish pathogenesis, was further characterized, and the enzyme was identified as a phospholipase B by gas chromatography. Site-directed mutagenesis revealed that a specific residue, Ser153, was critical for its enzymatic activity and for its virulence in fish. Copyright © 2007, American Society for Microbiology. All Rights Reserved.

    Original languageEnglish
    Pages (from-to)2575-2579
    Number of pages5
    JournalJournal of Bacteriology
    Volume189
    Issue number6
    DOIs
    Publication statusPublished - Mar 2007

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