A Sacrificial Linker in Biodegradable Polyesters for Accelerated Photoinduced Degradation, Monitored by Continuous Atline SEC Analysis

Samuel B. H. Patterson, Valeria Arrighi, Filipe Vilela*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

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Abstract

Polymeric materials that undergo photoinduced degradation have wide application in fields such as controlled release. Most methods for photoinduced degradation rely on the UV or near-UV region of the electromagnetic spectrum; however, use of the deeply penetrating and benign wavelengths of visible light offers a multitude of advantages. Here we report a lactone monomer for ring-opening copolymerizations to introduce a sacrificial linker into a polymer backbone which can be cleaved by reactive oxygen species which are produced by a photocatalyst under visible light irradiation. We find that copolymers of this material readily degrade under visible light. We followed polymer degradation using a continuous flow size exclusion chromatography system, the components of which are described herein.
Original languageEnglish
Pages (from-to)508-514
Number of pages7
JournalACS Macro Letters
Volume13
Issue number5
Early online date16 Apr 2024
DOIs
Publication statusPublished - 21 May 2024

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