A new technique for probing chirality via photoelectron circular dichroism

J. Miles, D. Fernandes, A. Young, C. M. M. Bond, S. W. Crane, Mohammed Omair Ghafur, David Townsend, J. Sá, J. B. Greenwood

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Abstract

We present a proof-of-principle approach for discriminating chiral enantiomers based on the phenomenon of multiphoton photoelectron circular dichroism. A novel stereo detection setup was used to measure the number of photoelectrons emitted from chiral molecules in directions parallel or anti-parallel to the propagation of the ionising femtosecond laser pulses. In this study, we show how these asymmetries in the ketones camphor and fenchone depend upon the ellipticity of the laser pulses and the enantiomeric excess of the sample. By using a high repetition rate femtosecond laser, enantiomer excesses with uncertainties at the few-percent level could be measured in close to real-time. As the instrument is compact, and commercial turnkey femtosecond lasers are readily available, the development of a stand-alone chiral analysis instrument for a range of applications is now possible.
Original languageEnglish
Pages (from-to)134-139
Number of pages6
JournalAnalytica Chimica Acta
Volume984
Early online date1 Jul 2017
DOIs
Publication statusPublished - 1 Sep 2017

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    Miles, J., Fernandes, D., Young, A., Bond, C. M. M., Crane, S. W., Ghafur, M. O., Townsend, D., Sá, J., & Greenwood, J. B. (2017). A new technique for probing chirality via photoelectron circular dichroism. Analytica Chimica Acta, 984, 134-139. https://doi.org/10.1016/j.aca.2017.06.051