A miniaturised chip on tip FLIM system for biomedical applications

Andrew B. Matheson, A. T. Erdogan, Charlotte Hopkinson, Sam Borrowman, Gary J. Loake, Michael G. Tanner, Robert K. Henderson

Research output: Contribution to conferencePaperpeer-review


Fluorescence lifetime imaging (FLIM) is a powerful tool which is increasingly being used for biomedical applications. We have developed a miniaturised chip on tip FLIM system suitable for widefield diagnostic imaging. It is based around a high dynamic range 120 x 128 pixel single photon avalanche diode (SPAD) array specifically designed for FLIM endoscopy [1]. The small footprint (~ 1 x 1 mm) of the device and streamlined electronic configuration mean it can be mounted on the distal end of an endoscope probe, unmounted and over 1 m away from the control board. This removes the need for scanning optics at the proximal end of the system and/or for an imaging fibre. We present results for this system on a range of ex vivo biological samples, showing that it can achieve excellent FLIM contrast at near video framerate in real time.

[1] - Erdogan et al., IEEE JSSC, 2022
Original languageEnglish
Publication statusPublished - 1 Sept 2022
EventPhoton 2022 - Nottingham
Duration: 30 Aug 20222 Sept 2022
Conference number: 11


ConferencePhoton 2022
Internet address


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