A miniaturised chip on tip FLIM system for biomedical applications

Andrew B. Matheson; A. T. Erdogan; Charlotte Hopkinson; Sam Borrowman; Gary J. Loake; Michael G. Tanner; Robert K. Henderson

A miniaturised chip on tip FLIM system for biomedical applications

Andrew B. Matheson, A. T. Erdogan, Charlotte Hopkinson, Sam Borrowman, Gary J. Loake, Michael G. Tanner, Robert K. Henderson

Research output: Contribution to conference › Paper › peer-review

Abstract

Fluorescence lifetime imaging (FLIM) is a powerful tool which is increasingly being used for biomedical applications. We have developed a miniaturised chip on tip FLIM system suitable for widefield diagnostic imaging. It is based around a high dynamic range 120 x 128 pixel single photon avalanche diode (SPAD) array specifically designed for FLIM endoscopy [1]. The small footprint (~ 1 x 1 mm) of the device and streamlined electronic configuration mean it can be mounted on the distal end of an endoscope probe, unmounted and over 1 m away from the control board. This removes the need for scanning optics at the proximal end of the system and/or for an imaging fibre. We present results for this system on a range of ex vivo biological samples, showing that it can achieve excellent FLIM contrast at near video framerate in real time.

[1] - Erdogan et al., IEEE JSSC, 2022

Original language	English
Publication status	Published - 1 Sept 2022
Event	Photon 2022 - Nottingham Duration: 30 Aug 2022 → 2 Sept 2022 Conference number: 11 https://www.photon.org.uk/

Conference

Conference	Photon 2022
Period	30/08/22 → 2/09/22
Internet address	https://www.photon.org.uk/

Cite this

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title = "A miniaturised chip on tip FLIM system for biomedical applications",

abstract = "Fluorescence lifetime imaging (FLIM) is a powerful tool which is increasingly being used for biomedical applications. We have developed a miniaturised chip on tip FLIM system suitable for widefield diagnostic imaging. It is based around a high dynamic range 120 x 128 pixel single photon avalanche diode (SPAD) array specifically designed for FLIM endoscopy [1]. The small footprint (~ 1 x 1 mm) of the device and streamlined electronic configuration mean it can be mounted on the distal end of an endoscope probe, unmounted and over 1 m away from the control board. This removes the need for scanning optics at the proximal end of the system and/or for an imaging fibre. We present results for this system on a range of ex vivo biological samples, showing that it can achieve excellent FLIM contrast at near video framerate in real time.[1] - Erdogan et al., IEEE JSSC, 2022 ",

author = "Matheson, {Andrew B.} and Erdogan, {A. T.} and Charlotte Hopkinson and Sam Borrowman and Loake, {Gary J.} and Tanner, {Michael G.} and Henderson, {Robert K.}",

year = "2022",

month = sep,

day = "1",

language = "English",

note = "Photon 2022 ; Conference date: 30-08-2022 Through 02-09-2022",

url = "https://www.photon.org.uk/",

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TY - CONF

T1 - A miniaturised chip on tip FLIM system for biomedical applications

AU - Matheson, Andrew B.

AU - Erdogan, A. T.

AU - Hopkinson, Charlotte

AU - Borrowman, Sam

AU - Loake, Gary J.

AU - Tanner, Michael G.

AU - Henderson, Robert K.

N1 - Conference code: 11

PY - 2022/9/1

Y1 - 2022/9/1

N2 - Fluorescence lifetime imaging (FLIM) is a powerful tool which is increasingly being used for biomedical applications. We have developed a miniaturised chip on tip FLIM system suitable for widefield diagnostic imaging. It is based around a high dynamic range 120 x 128 pixel single photon avalanche diode (SPAD) array specifically designed for FLIM endoscopy [1]. The small footprint (~ 1 x 1 mm) of the device and streamlined electronic configuration mean it can be mounted on the distal end of an endoscope probe, unmounted and over 1 m away from the control board. This removes the need for scanning optics at the proximal end of the system and/or for an imaging fibre. We present results for this system on a range of ex vivo biological samples, showing that it can achieve excellent FLIM contrast at near video framerate in real time.[1] - Erdogan et al., IEEE JSSC, 2022

AB - Fluorescence lifetime imaging (FLIM) is a powerful tool which is increasingly being used for biomedical applications. We have developed a miniaturised chip on tip FLIM system suitable for widefield diagnostic imaging. It is based around a high dynamic range 120 x 128 pixel single photon avalanche diode (SPAD) array specifically designed for FLIM endoscopy [1]. The small footprint (~ 1 x 1 mm) of the device and streamlined electronic configuration mean it can be mounted on the distal end of an endoscope probe, unmounted and over 1 m away from the control board. This removes the need for scanning optics at the proximal end of the system and/or for an imaging fibre. We present results for this system on a range of ex vivo biological samples, showing that it can achieve excellent FLIM contrast at near video framerate in real time.[1] - Erdogan et al., IEEE JSSC, 2022

M3 - Paper

T2 - Photon 2022

Y2 - 30 August 2022 through 2 September 2022

ER -

A miniaturised chip on tip FLIM system for biomedical applications

Abstract

Conference

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