A mild method for the synthesis of a novel dehydrobutyrine-containing amino acid

Alexandra M. Webster, Christopher R. Coxon, Alan M. Kenwright, Graham Sandford, Steven L. Cobb

Research output: Contribution to journalArticle

9 Citations (Scopus)
3 Downloads (Pure)

Abstract

Dehydrobutyrine is an amino acid that is present in a range of peptide natural products. Reaction of pentafluoropyridine with threonine and subsequent E1cb-type elimination allowed the preparation of novel dehydrobutyrine- containing amino acids under mild conditions.

Original languageEnglish
Pages (from-to)4661-4667
Number of pages7
JournalTetrahedron
Volume70
Issue number31
DOIs
Publication statusPublished - 5 Aug 2014

Keywords

  • Amino acid
  • Dehydrobutyrine
  • Nucleophilic aromatic substitution
  • Pentafluoropyridine

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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