Dehydrobutyrine is an amino acid that is present in a range of peptide natural products. Reaction of pentafluoropyridine with threonine and subsequent E1cb-type elimination allowed the preparation of novel dehydrobutyrine- containing amino acids under mild conditions.
- Amino acid
- Nucleophilic aromatic substitution
ASJC Scopus subject areas
- Drug Discovery
- Organic Chemistry