A micro-rheological and rheological study of biopolymers solutions: Hyaluronic acid

Andrea Dodero, Rhodri Williams, Simona Gagliardi, Silvia Vicini, Marina Alloisio, Maila Castellano

Research output: Contribution to journalArticlepeer-review

49 Citations (Scopus)
554 Downloads (Pure)


Hyaluronic acid (HA) solutions represent an important class of biomedical products, mostly used as viscosupplements in orthopaedics and as fillers in the cosmetic industry. The focus of the present work is the hydrodynamic, micro-rheological and rheological characterization of HA in physiological saline. Standard viscoelastic characterization techniques were coupled with micro-rheological measurements, i.e. by measuring the passive motions of particles embedded in the samples via Dynamic Light Scattering (DLS), effectively extending the accessible frequency range typical of standard rheometers. The influence of molecular weight and polymer concentration on the storage modulus (G’), loss modulus (G”) and complex viscosity (η*) of HA saline solutions was investigated. A brief comparison with theoretical models was made showing such concentrated solutions to be of a semi-flexible nature. In addition, the entanglement concentration ν the critical molecular weight M̄ c , and the mesh size ξ of the physical network created by the entangled polymer chains were calculated.

Original languageEnglish
Pages (from-to)349-355
Number of pages7
JournalCarbohydrate Polymers
Early online date28 Sept 2018
Publication statusPublished - 1 Jan 2019


  • Dynamic light scattering
  • Hyaluronic acid
  • Mesh size
  • Microrheology
  • Rheology
  • Sodium chloride (CID: 5234)
  • hyaluronic sodium salt (CID: 3084049)

ASJC Scopus subject areas

  • Organic Chemistry
  • Polymers and Plastics
  • Materials Chemistry


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