Abstract
A low-cost, in vitro laboratory experiment has been developed that mimics the absorption of a pharmaceutical drug in the body. It allows undergraduate chemistry students to gain experience in the measurement of drug permeability coefficients, a key indicator used by the pharmaceutical industry to identify
the ease of absorption of any new drug candidate. The experiment requires a diffusion cell, coated membrane, peristaltic pump and UV-Vis spectrophotometer. The method has been validated by determining the permeability coefficients for a selection of acidic, basic and non-ionizable drugs. Using this assay, it is possible to classify drugs as exhibiting high or low permeability in a fast, facile and reliable manner.
the ease of absorption of any new drug candidate. The experiment requires a diffusion cell, coated membrane, peristaltic pump and UV-Vis spectrophotometer. The method has been validated by determining the permeability coefficients for a selection of acidic, basic and non-ionizable drugs. Using this assay, it is possible to classify drugs as exhibiting high or low permeability in a fast, facile and reliable manner.
| Original language | English |
|---|---|
| Pages (from-to) | 310-313 |
| Number of pages | 4 |
| Journal | Chemical Educator |
| Volume | 19 |
| Early online date | 20 Oct 2014 |
| DOIs | |
| Publication status | Published - 2014 |
Keywords
- Pharmaceutical Chemistry; Pharmaceutical Drugs
- UV-Vis Spectroscopy
- Upper-Division Undergraduate
- Permeability
- Pharmaceutical Analysis