A hydrogel-based optical fibre fluorescent pH sensor for observing lung tumor tissue acidity

Jingjing Gong, Michael G. Tanner, Seshasailam Venkateswaran, James M. Stone, Yichuan Zhang, Mark Bradley

Research output: Contribution to journalArticle

Abstract

Technologies for measuring physiological parameters in vivo offer the possibility of the detection of disease and its progression due to the resulting changes in tissue pH, or temperature, etc. Here, a compact hydrogel-based optical fibre pH sensor was fabricated, in which polymer microarrays were utilized for the high-throughput discovery of an optimal matrix for pH indicator immobilization. The fabricated hydrogel-based probe responded rapidly to pH changes and demonstrated a good linear correlation within the physiological pH range (from 5.5 to 8.0) with a precision of 0.10 pH units. This miniature probe was validated by measuring pH across a whole ovine lung and allowed discrimination of tumorous and normal tissue, thus offering the potential for the rapid and accurate observation of tissue pH changes.

Original languageEnglish
Pages (from-to)136-143
Number of pages8
JournalAnalytica Chimica Acta
Volume1134
Early online date7 Aug 2020
DOIs
Publication statusE-pub ahead of print - 7 Aug 2020

Keywords

  • Hydrogel-based pH sensor
  • In situ photo-polymerization
  • Lung tumor
  • Optical fibre
  • Polymer microarray

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry
  • Environmental Chemistry
  • Spectroscopy

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