A high yielding route to substituted piperidines via the aza-Diels-Alder reaction

Patrick D. Bailey, Peter D. Smith, Frederick Pederson, William Clegg, Georgina M. Rosair, Simon J. Teat

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

The imine Ph2CHN=CHCO2Et, generated from benzhydrylamine and ethyl glyoxylate, is an excellent dienophile in aza-Diels-Alder reactions, giving diastereomerically pure cycloadducts in high yield. © 2002 Elsevier Science Ltd. All rights reserved.

Original languageEnglish
Pages (from-to)1067-1070
Number of pages4
JournalTetrahedron Letters
Volume43
Issue number6
DOIs
Publication statusPublished - 4 Feb 2002

Keywords

  • Alkaloids
  • Diels-Alder reaction
  • Piperidines

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