A femtosecond laser inscribed biochip for stem cell therapeutic applications

D. Choudhury, W. T. Ramsay, G. Brown, N. D. Psaila, S. Beecher, R. R. Thomson, R. Kiss, S. Pells, N. A. Willoughby, L. Paterson, A. K. Kar

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

A continuous flow microfluidic cell separation platform has been designed and fabricated using femtosecond laser inscription. The device is a scalable and non-invasive cell separation mechanism aimed at separating human embryonic stem cells from differentiated cells based on the dissimilarities in their cytoskeletal elasticity. Successful demonstration of the device has been achieved using human leukemia cells the elasticity of which is similar to that of human embryonic stem cells. © 2011 Copyright Society of Photo-Optical Instrumentation Engineers (SPIE).

Original languageEnglish
Title of host publicationMicrofluidics, BioMEMS, and Medical Microsystems IX
EditorsH Becker, BL Gray
Place of PublicationBELLINGHAM
PublisherSPIE
Pages-
Number of pages6
Volume7929
ISBN (Print)9780819484666
DOIs
Publication statusPublished - 2011
EventConference on Microfluidics, BioMEMS, and Medical Microsystems IX - San Francisco
Duration: 23 Jan 201125 Jan 2011

Conference

ConferenceConference on Microfluidics, BioMEMS, and Medical Microsystems IX
CitySan Francisco
Period23/01/1125/01/11

Keywords

  • cell separation
  • cell sorting
  • chemical etching
  • femtosecond laser inscription
  • fused silica
  • human embryonic stem cells

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