A feasibility study of singlet oxygen explicit dosmietry (SOED) of PDT by intercomparison with a singlet oxygen luminescence dosimetry (SOLD) system

Michele M. Kim, Rozhin Penjweini, Nathan R. Gemmell, Israel Veilleux, Aongus McCarthy, Gerald Stuart Buller, Robert H. Hadfield, Brian C. Wilson, Timothy C. Zhu

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

An explicit dosimetry model has been developed to calculate the apparent reacted 1O2 concentration ([1O2]rx) in an in-vivo model. In the model, a macroscopic quantity, g, is introduced to account for oxygen perfusion to the medium during PDT. In this study, the SOED model is extended for PDT treatment in phantom conditions where vasculature is not present; the oxygen perfusion is achieved through the air-phantom interface instead. The solution of the SOED model is obtained by solving the coupled photochemical rate equations incorporating oxygen perfusion through the air-liquid interface. Experiments were performed for two photosensitizers (PS), Rose Bengal (RB) and Photofrin, in solution, using SOED and SOLD measurements to determine both the instantaneous [1O2] as well as cumulative [1O2]rx concentrations, where [1O2=(1/τ)•∫[1O2]dt. The PS concentrations varied between 10 and 100 mM for RB and ∼200 mM for Photofrin. The resulting magnitudes of [1O2] were compared between SOED and SOLD.

Original languageEnglish
Title of host publicationProgress in Biomedical Optics and Imaging
EditorsDavid H. Kessel, Tayyaba Hasan
PublisherSPIE
ISBN (Print)9781628419283
DOIs
Publication statusPublished - 2016
EventOptical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXV - San Francisco, United States
Duration: 13 Feb 201614 Feb 2016

Publication series

NameProceedings of SPIE
PublisherSPIE
Volume9694
ISSN (Print)1605-7422

Conference

ConferenceOptical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXV
CountryUnited States
CitySan Francisco
Period13/02/1614/02/16

Keywords

  • explicit PDT dosimetry
  • PDT
  • photodynamic therapy
  • singlet oxygen
  • SOED
  • SOLD

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics
  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Radiology Nuclear Medicine and imaging

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  • Cite this

    Kim, M. M., Penjweini, R., Gemmell, N. R., Veilleux, I., McCarthy, A., Buller, G. S., Hadfield, R. H., Wilson, B. C., & Zhu, T. C. (2016). A feasibility study of singlet oxygen explicit dosmietry (SOED) of PDT by intercomparison with a singlet oxygen luminescence dosimetry (SOLD) system. In D. H. Kessel, & T. Hasan (Eds.), Progress in Biomedical Optics and Imaging [969406] (Proceedings of SPIE; Vol. 9694 ). SPIE. https://doi.org/10.1117/12.2213236