It has been demonstrated that code division multiple access (CDMA) provides great flexibility by enabling efficient multiuser access in a cellular environment. In addition, time division duplex (TDD) as compared to frequency division duplex (FDD) represents an appropriate method to cater for the asymmetric use of a duplex channel. However, the TDD technique is subject to additional interference mechanisms compared to an FDD system, in particular if neighboring cells require different rates of asymmetry. If TDD is combined with an interference limited multiple access technique such as CDMA, the additional interference mechanism represents an important issue. This issue poses the question of whether a CDMA/TDD air-interface can be used in a cellular environment. The problems are eased if a hybrid time division multiple access (TDMA)/CDMA interface (TD-CDMA) is used. The reason for this is that the TDMA component adds another degree of freedom which can be utilized to avoid interference. This, however, requires special channel assignment techniques. A notable example of a system which uses a TD-CDMA/TDD interface is the Universal Mobile Telecommunications System (UNITS). This paper presents a novel centralized dynamic channel assignment (DCA) algorithm for a TD-CDMA/TDD air-interface. The DCA algorithm exploits a new technique which is termed "TS-opposing technique." The key result is that the new DCA algorithm enables neighboring cells to adopt different rates of asymmetry without a significant capacity loss.