A comparison between image and signal sharpness-based axial localization of ultrasound scatterers

Konstantinos Diamantis, Paul A. Dalgarno, Tom Anderson, Jørgen Arendt Jensen, Vassilis Sboros

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)


Super-resolution ultrasound imaging deploys contrast microbubble (MB) tracking to delineate micro-vessels. The potential application spans to a large number of diseases which cause compromised vascular networks. Current super-resolution methods are mainly based on image processing. Sharpness-based localization is an alternative to such methods for scatterer localization in the axial direction, and can be implemented using both image and signal data. A 7-MHz, linear ultrasound transducer (\lambda = 212 \mu \mathrm{m}) and the Synthetic Aperture Real-time Ultrasound System (SARUS) were used to image a wire-target (point scatterer) at different depth positions. The method predicts a depth estimate and its difference from the true scatterer position demonstrates its accuracy. This average difference can be as low as 27.41 \mu \mathrm{m}( or \approx \lambda /8) for the image-derived sharpness and drops to 2.84 \mu \mathrm{m}( or \approx \quad \lambda /75) when the signals are used. These figures were calculated for a 8 mm depth range, which can be extended subject to further processing. The process of image formation involves interpolation and logarithmic compression that reduce the overall performance of the method when using image data. Such details may be significant when reconstructing micro-vessels of the order of tens of micrometres in diameter.

Original languageEnglish
Title of host publication2019 IEEE 16th International Symposium on Biomedical Imaging (ISBI 2019)
Number of pages4
ISBN (Electronic)9781538636411
Publication statusPublished - 11 Jul 2019
Event16th IEEE International Symposium on Biomedical Imaging 2019 - Venice, Italy
Duration: 8 Apr 201911 Apr 2019

Publication series

NameInternational Symposium on Biomedical Imaging
ISSN (Print)1945-7928
ISSN (Electronic)1945-8452


Conference16th IEEE International Symposium on Biomedical Imaging 2019
Abbreviated titleISBI 2019


  • Axial localization
  • Multiple focusing
  • Sharpness
  • Super-resolution ultrasound
  • Ultrasound scatterers

ASJC Scopus subject areas

  • Biomedical Engineering
  • Radiology Nuclear Medicine and imaging


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