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• Article

  A comparison of methods to assess cell mechanical properties

  Wu, P. H., Aroush, D. R. B., Asnacios, A., Chen, W. C., Dokukin, M. E., Doss, B. L., Durand-Smet, P., Ekpenyong, A., Guck, J., Guz, N. V., Janmey, P. A., Lee, J. S. H., Moore, N. M., Ott, A., Poh, Y. C., Ros, R., Sander, M., Sokolov, I., Staunton, J. R., Wang, N. & 2 others, Whyte, G. & Wirtz, D., 18 Jun 2018, In: Nature Methods. 15, p. 491-498 8 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Cellular Microenvironment
  • Rheology
  • Mechanical Stress
  • Atomic Force Microscopy
  • Elastic Modulus
  130 Citations (Scopus)

• Assessment of nanomaterial-induced hepatotoxicity using a 3D human primary multi-cellular microtissue exposed repeatedly over 21 days - the suitability of the in vitro system as an in vivo surrogate

  Kermanizadeh, A., Berthing, T., Guzniczak, E., Wheeldon, M., Whyte, G., Vogel, U., Moritz, W. & Stone, V., 19 Nov 2019, In: Particle and Fibre Toxicology. 16, 42.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Nanostructured materials
  • Nanostructures
  • Liver
  • Cytotoxicity
  • In Vitro Techniques
  5 Citations (Scopus)

  11 Downloads (Pure)

• Comparison of stresses on homogeneous spheroids in the optical stretcher computed with geometrical optics and generalized Lorenz-Mie theory

  Boyde, L., Ekpenyong, A., Whyte, G. & Guck, J., 20 Nov 2012, In: Applied Optics. 51, 33, p. 7934-7944 11 p.

  Research output: Contribution to journal › Article › peer-review

  • spheroids
  • Mie scattering
  • geometrical optics
  • cells
  • hinges
  18 Citations (Scopus)

• Deformability-induced lift force in spiral microchannels for cell separation

  Guzniczak, E., Otto, O., Whyte, G., Willoughby, N., Jimenez, M. & Bridle, H., 23 Dec 2019, In: Lab on a Chip.

  Research output: Contribution to journal › Article › peer-review

  • Cell Separation
  • Cell Size
  • Microfluidics
  • Biotechnology
  • Point-of-Care Systems
  7 Citations (Scopus)

• Dynamically reconfigurable fibre optical spanner

  Kolb, T., Albert, S., Haug, M. & Whyte, G., Feb 2014, In: Lab on a Chip. 14, p. 1186-1190 5 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Optical Fibers
  • Equipment and Supplies
  • Microfluidics
  • Confocal Microscopy
  15 Citations (Scopus)

  365 Downloads (Pure)

• Dynamic operation of optical fibres beyond the single-mode regime facilitates the orientation of biological cells

  Kreysing, M., Ott, D., Schmidberger, M. J., Otto, O., Schürmann, M., Martín-Badosa, E., Whyte, G. & Guck, J., 2014, In: Nature Communications. 5, 5481.

  Research output: Contribution to journal › Article › peer-review

  • Optical Fibers
  • Optical fibers
  • Optical Tweezers
  • optical fibers
  • Telecommunications
  31 Citations (Scopus)

• Elastic theory for the deformation of a solid or layered spheroid under axisymmetric loading

  Boyde, L., Ekpenyong, A., Whyte, G. & Guck, J., Apr 2013, In: Acta Mechanica. 224, 4, p. 819-839 21 p.

  Research output: Contribution to journal › Article › peer-review

  • Poisson ratio
  • Elastic constants
  • Cells
  • Microscopes
  • Elasticity
  6 Citations (Scopus)

• High-throughput assessment of mechanical properties of stem cell derived red blood cells, toward cellular downstream processing

  Guzniczak, E., Mohammad Zadeh, M., Dempsey, F., Jimenez, M., Bock, H., Whyte, G., Willoughby, N. & Bridle, H., 31 Oct 2017, In: Scientific Reports. 7, 14457.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Erythrocytes
  • Stem Cells
  • Elastic Modulus
  • Cell Nucleus
  • Atomic Force Microscopy
  12 Citations (Scopus)

  27 Downloads (Pure)

• High-throughput screening of antibiotic-resistant bacteria in picodroplets

  Liu, X., Painter, R. E., Enesa, K., Holmes, D., Whyte, G., Garlisi, C. G., Monsma, F. J., Rehak, M., Craig, F. F. & Smith, C. A., 2016, In: Lab on a Chip. 16, 9, p. 1636-1643 8 p.

  Research output: Contribution to journal › Article › peer-review
  50 Citations (Scopus)

• Image-based closed-loop feedback for highly mono-dispersed microdroplet production

  Crawford, D. F., Smith, C. A. & Whyte, G., 5 Sep 2017, In: Scientific Reports. 7, 10545.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Pressure
  • Microfluidics
  • Lab-On-A-Chip Devices
  • Growth and Development
  7 Citations (Scopus)

  38 Downloads (Pure)

• Image-Based Single Cell Sorting Automation in Droplet Microfluidics

  Sesen, M. & Whyte, G., 26 May 2020, In: Scientific Reports. 10, 8736.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Microfluidics
  • Sorting
  • Cells
  • Automation
  • Machine learning
  5 Citations (Scopus)

  33 Downloads (Pure)

• Impact of heating on passive and active biomechanics of suspended cells

  Chan, C. J., Whyte, G., Boyde, L., Salbreux, G. & Guck, J., Apr 2014, In: Interface Focus. 4, 2, p. 2013.0069 1 p.

  Research output: Contribution to journal › Article › peer-review

  • Heating
  • Biomechanical Phenomena
  • Temperature
  • TRPV Cation Channels
  • Mechanics
  26 Citations (Scopus)

• Mechanical environment modulates biological properties of oligodendrocyte progenitor cells.

  Jagielska, A., Norman, A. L., Whyte, G., Van Vliet, K. J., Guck, J., Franklin, R. J. M. & Vliet, K. J. V., Nov 2012, In: Stem Cells and Development. 21, 16, p. 2905-2914 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Oligodendrocyte Precursor Cells
  • Central Nervous System
  • Remyelination
  • Biophysics
  • Polystyrenes
  65 Citations (Scopus)

• Monitoring Early-Stage Nanoparticle Assembly in Microdroplets by Optical Spectroscopy and SERS

  Salmon, A. R., Esteban, R., Taylor, R. W., Hugall, J. T., Smith, C. A., Whyte, G., Scherman, O. A., Aizpurua, J., Abell, C. & Baumberg, J. J., 6 Apr 2016, In: Small. 12, 3, p. 1788–1796 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Raman spectroscopy
  • Raman Spectrum Analysis
  • Spectroscopy
  • Nanoparticles
  • Spectrum Analysis
  16 Citations (Scopus)

  49 Downloads (Pure)

• Optofluidic rotation of living cells for single-cell tomography

  Kolb, T., Albert, S., Haug, M. & Whyte, G., 2014, In: Journal of Biophotonics.

  Research output: Contribution to journal › Article › peer-review

  • Tomography
  • Flow Cytometry
  • Microfluidics
  • Suspensions
  • Microscopy
  19 Citations (Scopus)

• Optomechanical measurement of the role of Lamins in whole cell deformability

  Kolb, T., Kraxner, J., Skodzek, K., Haug, M., Crawford, D., Maaß, K. K., Aifantis, K. E. & Whyte, G., 9 May 2017, In: Journal of Biophotonics.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Lamins
  • Formability
  • Lamin Type A
  • Mechanical properties
  • cells
  2 Citations (Scopus)

  76 Downloads (Pure)

• Purifying stem cell-derived red blood cells: a high-throughput label-free downstream processing strategy based on microfluidic spiral inertial separation and membrane filtration

  Guzniczak, E., Otto, O., Whyte, G., Chandra, T., Robertson, N. A., Willoughby, N., Jimenez, M. & Bridle, H., Jul 2020, In: Biotechnology and Bioengineering. 117, 7, p. 2032-2045 14 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Stem cells
  • Microfluidics
  • Cells
  • Blood
  • Labels
  3 Citations (Scopus)

  1 Downloads (Pure)

• Separation of blood cells with differing deformability using deterministic lateral displacement

  Holmes, D., Whyte, G., Bailey, J., Vergara-Irigaray, N., Ekpenyong, A., Guck, J. & Duke, T., 2014, In: Interface Focus. 4, 6, 20140011.

  Research output: Contribution to journal › Article › peer-review

  • Blood Cells
  • Equipment and Supplies
  • Leukocytes
  • Hydrodynamics
  • Glutaral
  67 Citations (Scopus)

• Unbiased High-Precision Cell Mechanical Measurements with Microconstrictions

  Lange, J. R., Metzner, C., Richter, S., Schneider, W., Spermann, M., Kolb, T., Whyte, G. & Fabry, B., 11 Apr 2017, In: Biophysical Journal. 112, 7, p. 1472-1480 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • mechanical measurement
  • cells
  • modulus of elasticity
  • proteins
  • histograms
  22 Citations (Scopus)

  71 Downloads (Pure)

• Validation and perspectives of a femtosecond laser fabricated monolithic optical stretcher

  Bellini, N., Bragheri, F., Cristiani, I., Guck, J., Osellame, R. & Whyte, G., 1 Oct 2012, In: Biomedical Optics Express. 3, 10, p. 2658-2668 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Microfluidics
  • Glass
  • Lasers
  • Optical Fibers
  • Single-Cell Analysis
  37 Citations (Scopus)

  60 Downloads (Pure)

• Viscoelastic properties of differentiating blood cells are fate- and function-dependent.

  Ekpenyong, A. E., Whyte, G., Chalut, K., Pagliara, S., Lautenschläger, F., Fiddler, C., Paschke, S., Keyser, U. F., Chilvers, E. R. & Guck, J., Jan 2012, In: PLoS ONE. 7, 9, p. e45237-e45237

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Blood Cells
  • Myeloid Cells
  • Cell Differentiation
  • Physiological Adaptation
  • Differentiation Antigens
  110 Citations (Scopus)

  117 Downloads (Pure)
• Conference contribution

  Coherent Control of Light through Laser Written Photonic Lanterns

  Li, S., McNicholl, D. K., Whyte, G., Birks, T. A., Thomson, R. R. & Phillips, D. B., 10 Sep 2020, 2020 Conference on Lasers and Electro-Optics. IEEE, 9192265

  Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

  • Photonics
  • Imaging techniques
  • Lasers
  • Endoscopy
  • Microfluidics

• Fashioning microscopic tools

  Phillips, D. B., Whyte, G., Carberry, D. M., Hanna, S., Miles, M. J., Padgett, M. J. & Simpson, S. H., 2013, Optical Trapping and Optical Micromanipulation X. Dholakia, K. & Spalding, G. C. (eds.). Vol. 8810. 881029. (Proceedings of SPIE - The International Society for Optical Engineering; vol. 8810).

  Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

  • Optical tweezers
  • Position measurement
  • field theory (physics)
  • Molding
  • Physics
  3 Citations (Scopus)

• Femtosecond laser fabricated monolithic devices for single cell manipulation

  Bragheri, F., Minzioni, P., Vazquez, R. M., Bellini, N., Paiè, P., Mondello, C., Ramponi, R., Whyte, G., Cristiani, I., Guck, J. & Osellame, R., 2012, Frontiers in Optics 2012. Optical Society of America

  Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

  • laser machining
  • classifying
  • manipulators
  • chips
  • fluorescence

• High-resolution imaging of the nuclear envelope for investigation of the mechanical influence of the nucleus on cellular mechanics

  Kolb, T. & Whyte, G., 2013, Optical Molecular Probes, Imaging and Drug Delivery 2013. Optical Society of America, JT2A.33

  Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

  • cultured cells
  • Nuclear Envelope
  • Mechanics
  • Nuclear Proteins
  • envelopes

• Quantitative analysis of deformability-based cell separation using deterministic lateral displacement and optical stretching

  Holmes, D., Whyte, G., Ekpenyong, A., Guck, J. & Duke, T., 2012, Proceedings of the 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences. Chemical and Biological Microsystems Society, p. 536-538 3 p.

  Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

  • Stretching
  • Formability
  • Stiffness
  • Chemical analysis
  • Shear deformation

• Rotation of Optically Trapped Living Cells for Single-Cell Tomography

  Kolb, T. & Whyte, G., 2013, Optical Trapping Applications, OTA 2013. p. TM4D.4

  Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

  • tomography
  • Tomography
  • Microfluidics
  • cells
  • traps
  1 Citation (Scopus)

• Towards Photonic Lantern-Based Microendoscopy

  McNicholl, D., Li, S., Choudhury, D., Repetti, A., Griz-Sanchez, I., Whyte, G., Birks, T. A., Phillips, D. B., Wiaux, Y. & Thomson, R. R., 2020, Conference on Lasers and Electro-Optics/Pacific Rim 2020. Optical Society of America, C10D_5

  Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

  • Photonics
  • Waveguides
  • photonics
  • waveguides
• Meeting abstract

  Cell Mechanical Properties Measured with Micron-Scale Constrictions: Influence of Pressure, Strain and Culture Conditions

  Lange, J. R., Steinwachs, J., Metzner, C., Whyte, G. & Fabry, B., 16 Feb 2016, In: Biophysical Journal. 110, 3, Suppl. 1, p. 135a 1 p.

  Research output: Contribution to journal › Meeting abstract › peer-review
• Patent

  Microfluidic devices and systems

  Smith, C. A., Xin, L., Enesa, K., Liu, X., Craig, F. F. & Whyte, G., 2 Apr 2019, Patent No. 10,247,655, 30 Jul 2014

  Research output: Patent

  • microfluidic devices
  • cells
  • oils
  • refractivity
  • classifying

• Microfluidic systems

  Joaquim, T. R., Stafford, L. J., Chambers, R. S., Liu, X., Smith, C. A., Li, X. & Whyte, G., 23 Feb 2016, Patent No. US9267918 B2

  Research output: Patent

  • microfluidic devices
  • entry
  • electrodes
  • emulsions
  • chambers

• Microfluidic systems

  Abell, C., Huck, W. T. S., Bratton, D., Whyte, G. & Fidalgo, L. M., 9 Sep 2014, Patent No. US8828210 B2

  Research output: Patent

  • microfluidic technology
  • droplets
  • emulsions
  • fluids
  • magnetic fields