3D Shape Analysis of the Brain's Third Ventricle using a Midplane encoded Symmetric Template Model

Jaeil Kim, Maria del C. Valdés Hernández, Natalie A. Royle, Susana Muñoz Maniega, Benjamin S. Aribisala, Alan J. Gow, Mark E. Bastin, Ian J. Deary, Joanna M. Wardlaw, Jinah Park

    Research output: Contribution to journalArticle

    1 Citation (Scopus)
    36 Downloads (Pure)

    Abstract

    Background
    Structural changes of the brain's third ventricle have been acknowledged as an indicative measure of the brain atrophy progression in neurodegenerative and endocrinal diseases. To investigate the ventricular enlargement in relation to the atrophy of the surrounding structures, shape analysis is a promising approach. However, there are hurdles in modeling the third ventricle shape. First, it has topological variations across individuals due to the inter-thalamic adhesion. In addition, as an interhemispheric structure, it needs to be aligned to the midsagittal plane to assess its asymmetric and regional deformation.

    Method
    To address these issues, we propose a model-based shape assessment. Our template model of the third ventricle consists of a midplane and a symmetric mesh of generic shape. By mapping the template's midplane to the individuals’ brain midsagittal plane, we align the symmetric mesh on the midline of the brain before quantifying the third ventricle shape. To build the vertex-wise correspondence between the individual third ventricle and the template mesh, we employ a minimal-distortion surface deformation framework. In addition, to account for topological variations, we implement geometric constraints guiding the template mesh to have zero width where the inter-thalamic adhesion passes through, preventing vertices crossing between left and right walls of the third ventricle. The individual shapes are compared using a vertex-wise deformity from the symmetric template.

    Results
    Experiments on imaging and demographic data from a study of aging showed that our model was sensitive in assessing morphological differences between individuals in relation to brain volume (i.e. proxy for general brain atrophy), gender and the fluid intelligence at age 72. It also revealed that the proposed method can detect the regional and asymmetrical deformation unlike the conventional measures: volume (median 1.95 ml, IQR 0.96 ml) and width of the third ventricle. Similarity measures between binary masks and the shape model showed that the latter reconstructed shape details with high accuracy (Dice coefficient ≥0.9, mean distance 0.5 mm and Hausdorff distance 2.7 mm).

    Conclusions
    We have demonstrated that our approach is suitable to morphometrical analyses of the third ventricle, providing high accuracy and inter-subject consistency in the shape quantification. This shape modeling method with geometric constraints based on anatomical landmarks could be extended to other brain structures which require a consistent measurement basis in the morphometry.
    Original languageEnglish
    Pages (from-to)51-62
    Number of pages12
    JournalComputer Methods and Programs in Biomedicine
    Volume129
    Early online date28 Feb 2016
    DOIs
    Publication statusPublished - Jun 2016

    Fingerprint Dive into the research topics of '3D Shape Analysis of the Brain's Third Ventricle using a Midplane encoded Symmetric Template Model'. Together they form a unique fingerprint.

  • Cite this

    Kim, J., del C. Valdés Hernández, M., Royle, N. A., Muñoz Maniega, S., Aribisala, B. S., Gow, A. J., Bastin, M. E., Deary, I. J., Wardlaw, J. M., & Park, J. (2016). 3D Shape Analysis of the Brain's Third Ventricle using a Midplane encoded Symmetric Template Model. Computer Methods and Programs in Biomedicine, 129, 51-62. https://doi.org/10.1016/j.cmpb.2016.02.014