3D mapping of microfluidic flow in laboratory-on-a-chip structures using optical tweezers

Hasan Mushfique, Jonathan Leach, Huabing Yin, Roberto Di Leonardo, Miles J. Padgett, Jonathan M. Cooper

Research output: Contribution to journalArticle

Abstract

Accurate measurement of flow in microfluidic systems is both challenging and important, providing information that can be used to better understand flow fields within laboratory-on-a-chip devices and validate computational simulations. Here, we use optical tweezers within a microfluidic system to measure the velocity vectors of flow fields in two and three dimensions around a microstructures including both molded features within channels and cells. The experimental results are compared to a complex fluid dynamics model showing an agreement between the two of better than 3 mu m/s. This measurement is highly reproducible and minimally invasive, which in the future could be used to provided more in-depth studies of the rheological properties of biological cells and microstructures in laboratory-on-a-chip devices.

Original languageEnglish
Pages (from-to)4237-4240
Number of pages4
JournalAnalytical Chemistry
Volume80
Issue number11
DOIs
Publication statusPublished - 1 Jun 2008

Cite this

Mushfique, H., Leach, J., Yin, H., Di Leonardo, R., Padgett, M. J., & Cooper, J. M. (2008). 3D mapping of microfluidic flow in laboratory-on-a-chip structures using optical tweezers. Analytical Chemistry, 80(11), 4237-4240. https://doi.org/10.1021/ac8002006
Mushfique, Hasan ; Leach, Jonathan ; Yin, Huabing ; Di Leonardo, Roberto ; Padgett, Miles J. ; Cooper, Jonathan M. / 3D mapping of microfluidic flow in laboratory-on-a-chip structures using optical tweezers. In: Analytical Chemistry. 2008 ; Vol. 80, No. 11. pp. 4237-4240.
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Mushfique, H, Leach, J, Yin, H, Di Leonardo, R, Padgett, MJ & Cooper, JM 2008, '3D mapping of microfluidic flow in laboratory-on-a-chip structures using optical tweezers', Analytical Chemistry, vol. 80, no. 11, pp. 4237-4240. https://doi.org/10.1021/ac8002006

3D mapping of microfluidic flow in laboratory-on-a-chip structures using optical tweezers. / Mushfique, Hasan; Leach, Jonathan; Yin, Huabing; Di Leonardo, Roberto; Padgett, Miles J.; Cooper, Jonathan M.

In: Analytical Chemistry, Vol. 80, No. 11, 01.06.2008, p. 4237-4240.

Research output: Contribution to journalArticle

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AU - Leach, Jonathan

AU - Yin, Huabing

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AU - Padgett, Miles J.

AU - Cooper, Jonathan M.

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AB - Accurate measurement of flow in microfluidic systems is both challenging and important, providing information that can be used to better understand flow fields within laboratory-on-a-chip devices and validate computational simulations. Here, we use optical tweezers within a microfluidic system to measure the velocity vectors of flow fields in two and three dimensions around a microstructures including both molded features within channels and cells. The experimental results are compared to a complex fluid dynamics model showing an agreement between the two of better than 3 mu m/s. This measurement is highly reproducible and minimally invasive, which in the future could be used to provided more in-depth studies of the rheological properties of biological cells and microstructures in laboratory-on-a-chip devices.

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