[2]Rotaxanes through Palladium Active-Template Oxidative Heck Cross-Couplings

James D. Crowley, Kevin D. Hänni, Ai-Lan Lee, David A. Leigh

Research output: Contribution to journalArticlepeer-review

95 Citations (Scopus)


Pd(II)-catalyzed cross-couplings have been utilized in the efficient synthesis of [2]rotaxanes via an active-metal template strategy. The reaction is efficient, mild, and substrate-tolerant and uses only catalytic amounts of the Pd(II) template. In contrast, attempts using traditional Pd(0)-catalyzed cross-couplings led only to non-interlocked thread and no rotaxane.
Original languageEnglish
Pages (from-to)12092-12093
Number of pages2
JournalJournal of the American Chemical Society
Issue number40
Publication statusPublished - 1 Oct 2007


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