α1 and α2 domains of Aotus MHC class I and catarrhini MHC class Ia share similar characteristics

C. F. Suárez, P. P. Cárdenas, E. J. Llanos-Ballestas, P. Martínez, M. Obregón, M. E. Patarroyo, M. A. Patarroyo

    Research output: Contribution to journalArticlepeer-review

    12 Citations (Scopus)

    Abstract

    Functional and structural analyses of major histocompatibility complex (MHC) class I molecules of the Aotus genus are necessary to validate it as a solid animal model for biomedical research. We thus isolated, cloned and sequenced exons 2 and 3 from three Aotus species (A. nancymaae, A. nigriceps and A. vociferans). We found 24 sequences, which divided into two different groups (Ao-g1 and Ao-g2). A further sequence was identified as a processed pseudogene (Aona-PS2). Both sequence evolution and variability analyses showed that Ao-g1 and Ao-g2 display similar characteristics to Catarrhini's classical loci, such as positive selection pressure at the peptide binding region (PBR) high variability and a trans-specific evolution pattern.

    Original languageEnglish
    Pages (from-to)362-373
    Number of pages12
    JournalTissue Antigens
    Volume61
    Issue number5
    DOIs
    Publication statusPublished - May 2003

    Keywords

    • Animal models
    • Aotus
    • Evolution
    • MHC class I
    • PBR
    • Platyrrhini

    ASJC Scopus subject areas

    • Immunology
    • Cell Biology

    Fingerprint Dive into the research topics of 'α<sub>1</sub> and α<sub>2</sub> domains of Aotus MHC class I and catarrhini MHC class Ia share similar characteristics'. Together they form a unique fingerprint.

    Cite this