α-cycloPNA: 1-Aminocylopentane-1-carboxylic acid-derived peptide nucleic acid

Nicola M. Howarth; L. P G Wakelin; David M. Walker

doi:10.1081/NCN-120022963

α-cycloPNA: 1-Aminocylopentane-1-carboxylic acid-derived peptide nucleic acid

Nicola M. Howarth, L. P G Wakelin, David M. Walker

School of Engineering & Physical Sciences

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

All four diastereoisomers of 3-thymine-1-( ^tbutoxycarbonyl)aminocyclopentane-1-carboxylic acid have been synthesised from (S)-dimethyl malate and thymine monomer 12 has been incorporated into an a-cycloPNA oligomer.

Original language	English
Pages (from-to)	1351-1353
Number of pages	3
Journal	Nucleosides, Nucleotides and Nucleic Acids
Volume	22
Issue number	5-8
DOIs	https://doi.org/10.1081/NCN-120022963
Publication status	Published - 2003

Keywords

Cyclic α,α-disubstituted amino acids
PNA

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10.1081/NCN-120022963

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title = "α-cycloPNA: 1-Aminocylopentane-1-carboxylic acid-derived peptide nucleic acid",

abstract = "All four diastereoisomers of 3-thymine-1-( tbutoxycarbonyl)aminocyclopentane-1-carboxylic acid have been synthesised from (S)-dimethyl malate and thymine monomer 12 has been incorporated into an a-cycloPNA oligomer.",

keywords = "Cyclic α,α-disubstituted amino acids, PNA",

author = "Howarth, {Nicola M.} and Wakelin, {L. P G} and Walker, {David M.}",

year = "2003",

doi = "10.1081/NCN-120022963",

language = "English",

volume = "22",

pages = "1351--1353",

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issn = "1532-2335",

publisher = "Taylor & Francis",

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TY - JOUR

T1 - α-cycloPNA

T2 - 1-Aminocylopentane-1-carboxylic acid-derived peptide nucleic acid

AU - Howarth, Nicola M.

AU - Wakelin, L. P G

AU - Walker, David M.

PY - 2003

Y1 - 2003

N2 - All four diastereoisomers of 3-thymine-1-( tbutoxycarbonyl)aminocyclopentane-1-carboxylic acid have been synthesised from (S)-dimethyl malate and thymine monomer 12 has been incorporated into an a-cycloPNA oligomer.

AB - All four diastereoisomers of 3-thymine-1-( tbutoxycarbonyl)aminocyclopentane-1-carboxylic acid have been synthesised from (S)-dimethyl malate and thymine monomer 12 has been incorporated into an a-cycloPNA oligomer.

KW - Cyclic α,α-disubstituted amino acids

KW - PNA

UR - http://www.scopus.com/inward/record.url?scp=0141819258&partnerID=8YFLogxK

U2 - 10.1081/NCN-120022963

DO - 10.1081/NCN-120022963

M3 - Article

SN - 1532-2335

VL - 22

SP - 1351

EP - 1353

JO - Nucleosides, Nucleotides and Nucleic Acids

JF - Nucleosides, Nucleotides and Nucleic Acids

IS - 5-8

ER -

α-cycloPNA: 1-Aminocylopentane-1-carboxylic acid-derived peptide nucleic acid

Abstract

Keywords

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