α-cycloPNA

1-Aminocylopentane-1-carboxylic acid-derived peptide nucleic acid

Nicola M. Howarth, L. P G Wakelin, David M. Walker

Research output: Contribution to journalArticle

Abstract

All four diastereoisomers of 3-thymine-1-( tbutoxycarbonyl)aminocyclopentane-1-carboxylic acid have been synthesised from (S)-dimethyl malate and thymine monomer 12 has been incorporated into an a-cycloPNA oligomer.

Original languageEnglish
Pages (from-to)1351-1353
Number of pages3
JournalNucleosides, Nucleotides and Nucleic Acids
Volume22
Issue number5-8
DOIs
Publication statusPublished - 2003

Fingerprint

Peptide Nucleic Acids
Thymine
Carboxylic Acids
Oligomers
Monomers
malic acid

Keywords

  • Cyclic α,α-disubstituted amino acids
  • PNA

Cite this

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title = "α-cycloPNA: 1-Aminocylopentane-1-carboxylic acid-derived peptide nucleic acid",
abstract = "All four diastereoisomers of 3-thymine-1-( tbutoxycarbonyl)aminocyclopentane-1-carboxylic acid have been synthesised from (S)-dimethyl malate and thymine monomer 12 has been incorporated into an a-cycloPNA oligomer.",
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year = "2003",
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publisher = "Taylor & Francis",
number = "5-8",

}

α-cycloPNA : 1-Aminocylopentane-1-carboxylic acid-derived peptide nucleic acid. / Howarth, Nicola M.; Wakelin, L. P G; Walker, David M.

In: Nucleosides, Nucleotides and Nucleic Acids, Vol. 22, No. 5-8, 2003, p. 1351-1353.

Research output: Contribution to journalArticle

TY - JOUR

T1 - α-cycloPNA

T2 - 1-Aminocylopentane-1-carboxylic acid-derived peptide nucleic acid

AU - Howarth, Nicola M.

AU - Wakelin, L. P G

AU - Walker, David M.

PY - 2003

Y1 - 2003

N2 - All four diastereoisomers of 3-thymine-1-( tbutoxycarbonyl)aminocyclopentane-1-carboxylic acid have been synthesised from (S)-dimethyl malate and thymine monomer 12 has been incorporated into an a-cycloPNA oligomer.

AB - All four diastereoisomers of 3-thymine-1-( tbutoxycarbonyl)aminocyclopentane-1-carboxylic acid have been synthesised from (S)-dimethyl malate and thymine monomer 12 has been incorporated into an a-cycloPNA oligomer.

KW - Cyclic α,α-disubstituted amino acids

KW - PNA

UR - http://www.scopus.com/inward/record.url?scp=0141819258&partnerID=8YFLogxK

U2 - 10.1081/NCN-120022963

DO - 10.1081/NCN-120022963

M3 - Article

VL - 22

SP - 1351

EP - 1353

JO - Nucleosides, Nucleotides and Nucleic Acids

JF - Nucleosides, Nucleotides and Nucleic Acids

SN - 1525-7770

IS - 5-8

ER -