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Personal profile

Research interests

My mission: Musculoskeletal tissues developed remarkable mechanical properties through evolution. Understanding not only their reversible but also their outstanding irreversible properties is of major interest for human skeletal health and may allow tailoring bio-synthetic materials that follow the same micromechanical design and synthesis principles. Towards the latter idea, they represent attractive structural materials for high-end technological applications as well but with major advantages. Unlike man-made materials they are created in an energy efficient way and made of abundantly available constituents.

To decipher the irreversible behaviour of m
usculoskeletal tissues and mineralised tissues in particular, combined experimental, imaging, and computational approaches are pursued. The identified quantitative structure-mechanics relationships describing the behaviour of the fundamental building blocks are key to understand the mechanical design principles. This knowledge, in turn, is the basis to tailor bio-synthetic materials that follow the same design and synthesis principles as their natural antetype.

My current research is motivated
by the
serious personal, social, and economic burdens constituted by musculoskeletal diseases such as osteoporosis or osteoarthritis constitute. Osteoporosis affects 200 million women and causes 9 million fractures annually worldwide. Hip fracture incidence alone is projected to increase 240 % in women and 310 % in men by 2050. At the same time Europe will face associated costs of approximately e77 billion per year while in China over 500 million inhabitants are expected to suffer from osteoporosis (http://www.iofbonehealth.org). Osteoarthritis is the most prevalent chronic joint disease. It progressively deteriorates subchondral bone and articular cartilage and leaves patients immobile with a severely decreased quality of life and an increased mortality. The lifetime risk of developing osteoarthritis in the knee is approximately 40 % and 60 % in normal and obese subjects. Approximately 9.6 % of men and 18 % women over the age of 60 are suffering from osteoarthritis world-wide (http://www.arthritisresearchuk.org). Osteoporotic conditions develop in subchondral bone of affected joints in the later stage of the disease.

Life expectancy continues to rise but patient specific treatment solutions to optimally manage those patients are sill not available. Such solutions could consist of a tailored medication strategies and, at a later stage, tailored implant solutions. The unavailability of the latter is due to the fact that the irreversible mechanical behaviour of bone–especially at the level of the extra-cellular matrix (ECM)–is not fully understood. Consequently, understanding this behaviour could form the basis to engineer patient specific treatment solutions

 

Biography

I joined the School of Engineering & Physical Sciences at Heriot-Watt University as an Assistant Professor in August 2015.

Before this I did a postdoc at the Institute for Surgical Technology and Biomechanics in Bern, Switzerland where I managed the renovation and set-up of a biomechanics laboratory. My research during this time focussed on the relevance of anisotropic damage in the fracture risk of the hip.

In 2011, I finished my PhD at the Institute for Orthopaedic Research and Biomechanics in Ulm, Germany, where I worked on the mechanical multiscale characterisation of vertebral trabecular bone for the prediction of vertebral fracture risk. During my PhD in 2008/09, I was a guest researcher at the Institute of Lightweight Design and Structural Biomechanics at Vienna University of Technology, Austria, to perform microsocpic and macroscopic experiments. Just after starting my PhD in 2006, I was a guest researcher at the Institute for Numerical Simulation of Bonn University, Germany, within a collaboration to validate a novel finite element code that could be of use for porous media such as bone.

In 2005, I graduated as Diplom Ingenieur, a former German equivalent to the Master of Science, in Mechanical Engineering at Chemnitz University of Technology, Germany, with an anatomy-based kinematic model of the hindlimb of the rat to compute muscle forces during gait.

My work was published in over 30 peer reviewed articles as first, last (PI), or co-author in top journals of my research area such as Bone, Journal of the Mechanical Behaviour of Biomedical Materials, or Nature Materials see

  • http://scholar.google.ch/citations?user=VHn8uAkAAAAJ or
  • http://www.researcherid.com/rid/C-7454-2011.

Furthermore, I contributed to over 50 conferences including invited talks and lectures, e.g., World Congress of Biomechanics 2014 and European Calcified Tissue Society 2016.

 

Keywords

  • TJ Mechanical engineering and machinery
  • Tissue Biomechanics
  • Materials Science
  • Experimental Mechanics
  • Computational Mechanics
  • Image Processing

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Research Output

Crumbling Reefs and Cold-Water Coral Habitat Loss in a Future Ocean: Evidence of “Coralporosis” as an Indicator of Habitat Integrity

Hennige, S. J., Wolfram, U., Wickes, L., Murray, F., Roberts, J. M., Kamenos, N. A., Schofield, S., Groetsch, A., Spiesz, E. M., Aubin-Tam, M. E. & Etnoyer, P. J., 17 Sep 2020, In : Frontiers in Marine Science. 7, 668.

Research output: Contribution to journalArticle

Open Access
File
  • 1 Downloads (Pure)

    Extrafibrillar matrix yield stress and failure envelopes for mineralised collagen fibril arrays

    Speed, A., Groetsch, A., Schwiedrzik, J. J. & Wolfram, U., May 2020, In : Journal of the Mechanical Behavior of Biomedical Materials. 105, 103563.

    Research output: Contribution to journalArticle

  • 1 Citation (Scopus)

    Compositional and mechanical properties of growing cortical bone tissue: a study of the human fibula

    Lefèvre, E., Farlay, D., Bala, Y., Subtil, F., Wolfram, U., Rizzo, S., Baron, C., Zysset, P., Pithioux, M. & Follet, H., 26 Nov 2019, In : Scientific Reports. 9, 17629.

    Research output: Contribution to journalArticle

    Open Access
    File
  • 3 Citations (Scopus)
    11 Downloads (Pure)

    Compressive behaviour of uniaxially aligned individual mineralised collagen fibres at the micro- and nanoscale

    Groetsch, A., Gourrier, A., Schwiedrzik, J., Sztucki, M., Beck, R. J., Shephard, J. D., Michler, J., Zysset, P. K. & Wolfram, U., 15 Apr 2019, In : Acta Biomaterialia. 89, p. 313-329 17 p.

    Research output: Contribution to journalArticle

    Open Access
    File
  • 5 Citations (Scopus)
    18 Downloads (Pure)

    “Peroperative Estimation of Bone Quality and Primary Dental Implant Stability”

    Voumard, B., Maquer, G., Heuberger, P., Zysset, P. K. & Wolfram, U., Apr 2019, In : Journal of the Mechanical Behavior of Biomedical Materials. 92, p. 24-32 9 p.

    Research output: Contribution to journalArticle

    Open Access
    File
  • 3 Citations (Scopus)
    25 Downloads (Pure)

    Equipment

    CAESAR - Preparation Room

    Uwe Wolfram (Manager)

    School of Engineering

    Facility/equipment: Equipment