19952020

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2020

Mechanism of Action of an EPAC1-Selective Competitive Partial Agonist

Shao, H., Mohamed, H., Boulton, S., Huang, J., Wang, P., Chen, H., Zhou, J., Luchowska-Stańska, U., Jentsch, N. G., Armstrong, A. L., Magolan, J., Yarwood, S. & Melacini, G., 14 May 2020, In : Journal of Medicinal Chemistry. 63, 9, p. 4762-4775 14 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Synthesis and Biochemical Evaluation of Noncyclic Nucleotide Exchange Proteins Directly Activated by cAMP 1 (EPAC1) Regulators

Wang, P., Luchowska-Stańska, U., Van Basten, B., Chen, H., Liu, Z., Wiejak, J., Whelan, P., Morgan, D., Lochhead, E., Barker, G., Rehmann, H., Yarwood, S. J. & Zhou, J., 28 May 2020, In : Journal of Medicinal Chemistry. 63, 10, p. 5159–5184 26 p.

Research output: Contribution to journalArticle

2019

Genome-Wide Mapping Defines a Role for C/EBPβ and c-Jun in Non-Canonical Cyclic AMP Signalling

Wiejak, J., van Basten, B., Hamilton, G. & Yarwood, S. J., 14 Oct 2019, In : Cells. 8, 10, 1253.

Research output: Contribution to journalArticle

Open Access
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6 Downloads (Pure)

Identification of A Novel Class of Benzofuran Oxoacetic Acid-Derived Ligands that Selectively Activate Cellular EPAC1

Beck, E. M., Parnell, E., Cowley, A., Porter, A., Gillespie, J., Robinson, J., Robinson, L., Pannifer, A. D., Hamon, V., Jones, P., Morrison, A., McElroy, S., Timmerman, M., Rutjes, H., Mahajan, P., Wiejak, J., Luchowska-Stańska, U., Morgan, D., Barker, G., Rehmann, H. & 1 others, Yarwood, S. J., 12 Nov 2019, In : Cells. 8, 11, 1425.

Research output: Contribution to journalArticle

Open Access
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5 Downloads (Pure)

Selective small-molecule EPAC activators

Luchowska-Stańska, U., Morgan, D., Yarwood, S. J. & Barker, G., 11 Oct 2019, In : Biochemical Society Transactions. 47, 5, p. 1415-1427 13 p.

Research output: Contribution to journalArticle

Open Access
File
34 Downloads (Pure)
Open Access
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4 Citations (Scopus)
22 Downloads (Pure)
2017

Identification of a Novel, Small Molecule Partial Agonist for the Cyclic AMP Sensor, EPAC1

Parnell, E., McElroy, S. P., Wiejak, J., Baillie, G. L., Porter, A., Adams, D. R., Rehmann, H., Smith, B. O. & Yarwood, S. J., 22 Mar 2017, In : Scientific Reports. 7, 294.

Research output: Contribution to journalArticle

Open Access
File
10 Citations (Scopus)
50 Downloads (Pure)

Metformin suppresses adipogenesis through both AMP-activated protein kinase (AMPK)-dependent and AMPK-independent mechanisms

Chen, S. C., Brooks, R., Houskeeper, J., Bremner, S. K., Dunlop, J., Viollet, B., Logan, P. J., Salt, I. P., Ahmed, S. F. & Yarwood, S. J., 15 Jan 2017, In : Molecular and Cellular Endocrinology. 440, p. 57–68 12 p.

Research output: Contribution to journalArticle

Open Access
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43 Citations (Scopus)
76 Downloads (Pure)

Nanotopography controls cell cycle changes involved with skeletal stem cell self-renewal and multipotency

Lee, L. C. Y., Gadegaard, N., De Andrés, M. C., Turner, L-A., Burgess, K. E. V., Yarwood, S. J., Wells, J., Salmeron-Sanchez, M., Meek, R. M. D., Oreffo, R. O. C. & Dalby, M. J., Feb 2017, In : Biomaterials. 116, p. 10-20 11 p.

Research output: Contribution to journalArticle

Open Access
File
28 Citations (Scopus)
34 Downloads (Pure)

Probe-dependent negative allosteric modulators of the long-chain free fatty acid receptor FFA4

Watterson, K. R., Hansen, S. V. F., Hudson, B., Alvarez-Curto, E., Raihan, S. Z., Azevedo, C. M. G., Martin, G., Dunlop, J., Yarwood, S. J., Ulven, T. & Milligan, G., 1 Jun 2017, In : Molecular Pharmacology. 91, 6, p. 630-641 12 p.

Research output: Contribution to journalArticle

Open Access
File
12 Citations (Scopus)
20 Downloads (Pure)
Open Access
File
3 Citations (Scopus)
46 Downloads (Pure)
2016

Dynamic Surfaces for the Study of Mesenchymal Stem Cell Growth through Adhesion Regulation

Roberts, J. N., Sahoo, J. K., Mcnamara, L. E., Burgess, K. E. V., Yang, J., Alakpa, E. V., Anderson, H. J., Hay, J., Turner, L-A., Yarwood, S. J., Zelzer, M., Oreffo, R. O. C., Ulijn, R. V. & Dalby, M. J., Jul 2016, In : ACS Nano.

Research output: Contribution to journalArticle

Open Access
File
45 Citations (Scopus)
41 Downloads (Pure)

Epac1 links prostaglandin E2 to β-catenin-dependent transcription during epithelial-to-mesenchymal transition

Jansen, S. R., Poppinga, W. J., De Jager, W., Lezoualc'h, F., Cheng, X., Wieland, T., Yarwood, S., Gosens, R. & Schmidt, M., Jul 2016, In : Oncotarget. 7, 29

Research output: Contribution to journalArticle

Open Access
File
11 Citations (Scopus)
33 Downloads (Pure)
2015

Adhesion and migration of cells responding to microtopography

Estévez, M., Martínez, E., Yarwood, S. J., Dalby, M. J. & Samitier, J., May 2015, In : Journal of Biomedical Materials Research Part A. 103, 5, p. 1659-1668 10 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)

Phosphorylation of ezrin on Thr567 is required for the synergistic activation of cell spreading by EPAC1 and protein kinase A in HEK293T cells

Parnell, E., Koschinski, A., Zaccolo, M., Cameron, R. T., Baillie, G. S., Baillie, G. L., Porter, A., McElroy, S. P. & Yarwood, S. J., Jul 2015, In : Biochimica et Biophysica Acta. 1853, 7, p. 1749-1758 10 p.

Research output: Contribution to journalArticle

Open Access
File
9 Citations (Scopus)
18 Downloads (Pure)

Regulation of anti-inflammatory gene expression in vascular endothelial cells by EPAC1

Palmer, T. M. & Yarwood, S. J., 9 Nov 2015, In : Journal of Cell Signaling. 1, 1, 1000103.

Research output: Contribution to journalArticle

Open Access
File
33 Downloads (Pure)

Serine-727 phosphorylation activates hypothalamic STAT-3 independently from tyrosine-705 phosphorylation

Breit, A., Besik, V., Solinski, H. J., Muehlich, S., Glas, E., Yarwood, S. J. & Gudermann, T., Mar 2015, In : Molecular Endocrinology. 29, 3, p. 445-459 15 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

The cAMP sensors, EPAC1 and EPAC2, display distinct subcellular distributions despite sharing a common nuclear pore localisation signal

Parnell, E., Smith, B. O. & Yarwood, S. J., May 2015, In : Cellular Signalling. 27, 5, p. 989-996 8 p.

Research output: Contribution to journalArticle

Open Access
14 Citations (Scopus)

The future of EPAC-targeted therapies: agonism versus antagonism

Parnell, E., Palmer, T. M. & Yarwood, S. J., Apr 2015, In : Trends in Pharmacological Sciences. 36, 4, p. 203-214 12 p.

Research output: Contribution to journalArticle

Open Access
44 Citations (Scopus)
2014

Interactions between Epac1 and ezrin in the control of endothelial barrier function

Parnell, E. & Yarwood, S. J., Apr 2014, In : Biochemical Society Transactions. 42, 2, p. 274-278 5 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Nanotopology potentiates growth hormone signalling and osteogenesis of mesenchymal stem cells

Wang, J. R., Ahmed, S. F., Gadegaard, N., Meek, R. M. D., Dalby, M. J. & Yarwood, S. J., Dec 2014, In : Growth Hormone and IGF Research. 24, 6, p. 245-250 6 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)

Targeting SOCS proteins to combat inflammation

Yarwood, S., 2014, In : Endocrine Abstracts. 34 , S8.2

Research output: Contribution to journalArticle

The role of c-Jun in controlling the EPAC1-dependent induction of the SOCS3 gene in HUVECs

Wiejak, J., Dunlop, J. & Yarwood, S. J., 2 May 2014, In : FEBS Letters. 588, 9, p. 1556-1561 6 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)
2013
25 Citations (Scopus)

Genomic analysis of the role of transcription factor C/EBPδ in the regulation of cell behaviour on nanometric grooves

Wiejak, J., Tsimbouri, P. M., Herzyk, P., Dalby, M. J., Hamilton, G. & Yarwood, S. J., Mar 2013, In : Biomaterials. 34, 8, p. 1967-1979 13 p.

Research output: Contribution to journalArticle

Open Access
5 Citations (Scopus)

Modulation of mesenchymal stem cell differentiation by alterations in GH action and cell-matrix interaction

Wang, R. J., Yarwood, S., Dalby, M. & Ahmed, F., 2013, In : Endocrine Abstracts. 33, P65

Research output: Contribution to journalArticle

2012
12 Citations (Scopus)

Novel control of cAMP-regulated transcription in vascular endothelial cells

Milne, G. R., Palmer, T. M. & Yarwood, S. J., Feb 2012, In : Biochemical Society Transactions. 40, 1, p. 1-5 5 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Regulation of the inflammatory response of vascular endothelial cells by EPAC1

Parnell, E., Smith, B. O., Palmer, T. M., Terrin, A., Zaccolo, M. & Yarwood, S. J., May 2012, In : British Journal of Pharmacology. 166, 2, p. 434-446 13 p.

Research output: Contribution to journalArticle

36 Citations (Scopus)

The protein kinase C inhibitor, Ro-31-7459, is a potent activator of ERK and JNK MAP kinases in HUVECs and yet inhibits cyclic AMP-stimulated SOCS-3 gene induction through inactivation of the transcription factor c-Jun

Wiejak, J., Dunlop, J., Stoyle, C., Lappin, G., McIlroy, A., Pediani, J. D., Gao, S. & Yarwood, S. J., Aug 2012, In : Cellular Signalling. 24, 8, p. 1690-1699 10 p.

Research output: Contribution to journalArticle

Open Access
5 Citations (Scopus)
2010
26 Citations (Scopus)
2009
43 Citations (Scopus)

EPAC proteins transduce diverse cellular actions of cAMP

Borland, G., Smith, B. O. & Yarwood, S. J., Sep 2009, In : British Journal of Pharmacology. 158, 1, p. 70-86 17 p.

Research output: Contribution to journalArticle

99 Citations (Scopus)

Mimitin - a novel cytokine-regulated mitochondrial protein

Wegrzyn, P., Yarwood, S. J., Fiegler, N., Bzowska, M., Koj, A., Mizgalska, D., Malicki, S., Pajak, M., Kasza, A., Kachamakova-Trojanowska, N., Bereta, J., Jura, J. & Jura, J., 2009, In : BMC Cell Biology . 10, 23.

Research output: Contribution to journalArticle

Open Access
12 Citations (Scopus)

Selective inhibition of cytokine-activated extracellular signal-regulated kinase by cyclic AMP via Epac1-dependent induction of suppressor of cytokine signalling-3

Woolson, H. D., Thomson, V. S., Rutherford, C., Yarwood, S. J. & Palmer, T. M., Nov 2009, In : Cellular Signalling. 21, 11, p. 1706-1715 10 p.

Research output: Contribution to journalArticle

37 Citations (Scopus)
2008

Identification of CCAAT/enhancer-binding proteins as exchange protein activated by cAMP-activated transcription factors that mediate the induction of the SOCS-3 gene

Yarwood, S. J., Borland, G., Sands, W. A. & Palmer, T. M., 14 Mar 2008, In : Journal of Biological Chemistry. 283, 11, p. 6843-6853 11 p.

Research output: Contribution to journalArticle

61 Citations (Scopus)

The effect of the RACK1 signalling protein on the regulation of cell adhesion and cell contact guidance on nanometric grooves

Dalby, M. J., Hart, A. & Yarwood, S. J., Jan 2008, In : Biomaterials. 29, 3, p. 282-289 8 p.

Research output: Contribution to journalArticle

47 Citations (Scopus)
2006

Microtubule-associated protein 1B-light chain 1 enhances activation of Rap1 by exchange protein activated by cyclic AMP but not intracellular targeting

Borland, G., Gupta, M., Magiera, M. M., Rundell, C. J., Fuld, S. & Yarwood, S. J., Jan 2006, In : Molecular Pharmacology. 69, 1, p. 374-384 11 p.

Research output: Contribution to journalArticle

36 Citations (Scopus)

RACK 1 associated with focal adhesions alters the cells sensitivity to contact guidance

Hart, A., Yarwood, S. & Dalby, M. J., Jun 2006, In : European Cells and Materials . 11, Supplement 2, p. 80 1 p.

Research output: Contribution to journalArticle

2005
28 Citations (Scopus)
31 Citations (Scopus)
13 Citations (Scopus)
2004

Effect of cellular uptake of gelatin nanoparticles on adhesion, morphology and cytoskeleton organisation of human fibroblasts

Gupta, A. K., Gupta, M., Yarwood, S. J. & Curtis, A. S. G., 5 Mar 2004, In : Journal of Controlled Release. 95, 2, p. 197-207 11 p.

Research output: Contribution to journalArticle

144 Citations (Scopus)

Exchange protein directly activated by cAMP (EPAC) interacts with the light chain (LC) 2 of MAP1A

Magiera, M. M., Gupta, M., Rundell, C. J., Satish, N., Ernens, I. & Yarwood, S. J., 15 Sep 2004, In : Biochemical Journal. 382, 3, p. 803-810 8 p.

Research output: Contribution to journalArticle

27 Citations (Scopus)

Protease inhibitors prevent the protein kinase A-dependent loss of Rap1 GTPase from the particulate fraction of COS1 cells

Rundell, C. J., Repellin, C. E. & Yarwood, S. J., 19 Mar 2004, In : Biochemical and Biophysical Research Communications. 315, 4, p. 1077-1081 5 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)
2003

Nucleus alignment and cell signaling in fibroblasts: response to a micro-grooved topography

Dalby, M. J., Riehle, M. O., Yarwood, S. J., Wilkinson, C. D. W. & Curtis, A. S. G., 1 Apr 2003, In : Experimental Cell Research. 284, 2, p. 274-282 9 p.

Research output: Contribution to journalArticle

261 Citations (Scopus)

Preparation and in vitro evaluation of pullulan nanoparticles as gene transfection system

Gupta, M., Gupta, A. K., Curtis, A. S. G. & Yarwood, S., Sep 2003, In : European Cells and Materials . 6, Supplement 2, p. 39 1 p.

Research output: Contribution to journalArticle

2002

Delineation of RAID1, the RACK1 interaction domain located within the unique N-terminal region of the cAMP-specific phosphodiesterase, PDE4D5

Bolger, G. B., McCahill, A., Yarwood, S. J., Steele, M. R., Warwicker, J. & Houslay, M. D., 2002, In : BMC Biochemistry. 3, 24.

Research output: Contribution to journalArticle

Open Access
36 Citations (Scopus)

Fibroblast signaling events in response to nanotopography: a gene array study

Dalby, M. J., Yarwood, S. J., Johnstone, H. J. H., Affrossman, S. & Riehle, M. O., Mar 2002, In : IEEE Transactions on NanoBioscience. 1, 1, p. 12-17 6 p.

Research output: Contribution to journalArticle

42 Citations (Scopus)

In addition to the SH3 binding region, multiple regions within the N-terminal noncatalytic portion of the cAMP-specific phosphodiesterase, PDE4A5, contribute to its intracellular targeting

Beard, M. B., Huston, E., Campbell, L., Gall, I., McPhee, I., Yarwood, S., Scotland, G. & Houslay, M. D., May 2002, In : Cellular Signalling. 14, 5, p. 453-465 13 p.

Research output: Contribution to journalArticle

35 Citations (Scopus)