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Research Output 1995 2019

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2019

Genome-Wide Mapping Defines a Role for C/EBPβ and c-Jun in Non-Canonical Cyclic AMP Signalling

Wiejak, J., van Basten, B., Hamilton, G. & Yarwood, S. J., 14 Oct 2019, In : Cells. 8, 10, 1253.

Research output: Contribution to journalArticle

Open Access
File
Chromosome Mapping
Cyclic AMP
Rolipram
Interleukin-6
Colforsin

Identification of A Novel Class of Benzofuran Oxoacetic Acid-Derived Ligands that Selectively Activate Cellular EPAC1

Beck, E. M., Parnell, E., Cowley, A., Porter, A., Gillespie, J., Robinson, J., Robinson, L., Pannifer, A. D., Hamon, V., Jones, P., Morrison, A., McElroy, S., Timmerman, M., Rutjes, H., Mahajan, P., Wiejak, J., Luchowska-Stańska, U., Morgan, D., Barker, G., Rehmann, H. & 1 others, Yarwood, S. J., 12 Nov 2019, In : Cells. 8, 11, 1425.

Research output: Contribution to journalArticle

Open Access
File
GTP Phosphohydrolases
Cyclic Nucleotides
Nucleotides
High-Throughput Screening Assays
Ligands

Selective small-molecule EPAC activators

Luchowska-Stańska, U., Morgan, D., Yarwood, S. J. & Barker, G., 11 Oct 2019, In : Biochemical Society Transactions. 47, 5, p. 1415-1427 13 p.

Research output: Contribution to journalArticle

Open Access
File
Cyclic Nucleotides
Adenosine Monophosphate
Cyclic AMP-Dependent Protein Kinases
Vascular Resistance
Insulin Resistance
Open Access
File
Umbilicus
Cyclic AMP
Endothelial Cells
Gene Expression
Proteins
2017

Identification of a Novel, Small Molecule Partial Agonist for the Cyclic AMP Sensor, EPAC1

Parnell, E., McElroy, S. P., Wiejak, J., Baillie, G. L., Porter, A., Adams, D. R., Rehmann, H., Smith, B. O. & Yarwood, S. J., 22 Mar 2017, In : Scientific Reports. 7, 294.

Research output: Contribution to journalArticle

Open Access
File

Metformin suppresses adipogenesis through both AMP-activated protein kinase (AMPK)-dependent and AMPK-independent mechanisms

Chen, S. C., Brooks, R., Houskeeper, J., Bremner, S. K., Dunlop, J., Viollet, B., Logan, P. J., Salt, I. P., Ahmed, S. F. & Yarwood, S. J., 15 Jan 2017, In : Molecular and Cellular Endocrinology. 440, p. 57–68 12 p.

Research output: Contribution to journalArticle

Open Access
File
Adipogenesis
AMP-Activated Protein Kinases
Metformin
Transcription Factors
70-kDa Ribosomal Protein S6 Kinases

Nanotopography controls cell cycle changes involved with skeletal stem cell self-renewal and multipotency

Lee, L. C. Y., Gadegaard, N., De Andrés, M. C., Turner, L-A., Burgess, K. E. V., Yarwood, S. J., Wells, J., Salmeron-Sanchez, M., Meek, R. M. D., Oreffo, R. O. C. & Dalby, M. J., Feb 2017, In : Biomaterials. 116, p. 10-20 11 p.

Research output: Contribution to journalArticle

Open Access
File
Cell Cycle Checkpoints
Stem Cells
Fibroblasts
Bone Marrow
Multipotent Stem Cells

Probe-dependent negative allosteric modulators of the long-chain free fatty acid receptor FFA4

Watterson, K. R., Hansen, S. V. F., Hudson, B., Alvarez-Curto, E., Raihan, S. Z., Azevedo, C. M. G., Martin, G., Dunlop, J., Yarwood, S. J., Ulven, T. & Milligan, G., 1 Jun 2017, In : Molecular Pharmacology. 91, 6, p. 630-641 12 p.

Research output: Contribution to journalArticle

Open Access
File
Nonesterified Fatty Acids
G-Protein-Coupled Receptors
Mesenchymal Stromal Cells
Adipocytes
Type 2 Diabetes Mellitus
Open Access
File
Phosphoric Diester Hydrolases
Cyclic AMP
Protein Kinase C
Focal Adhesions
Integrins
2016

Dynamic Surfaces for the Study of Mesenchymal Stem Cell Growth through Adhesion Regulation

Roberts, J. N., Sahoo, J. K., Mcnamara, L. E., Burgess, K. E. V., Yang, J., Alakpa, E. V., Anderson, H. J., Hay, J., Turner, L-A., Yarwood, S. J., Zelzer, M., Oreffo, R. O. C., Ulijn, R. V. & Dalby, M. J., Jul 2016, In : ACS Nano.

Research output: Contribution to journalArticle

Open Access
File
Mesenchymal Stromal Cells
Stem Cells
Growth
Cell Culture Techniques
Adult Stem Cells

Epac1 links prostaglandin E2 to β-catenin-dependent transcription during epithelial-to-mesenchymal transition

Jansen, S. R., Poppinga, W. J., De Jager, W., Lezoualc'h, F., Cheng, X., Wieland, T., Yarwood, S., Gosens, R. & Schmidt, M., Jul 2016, In : Oncotarget. 7, 29

Research output: Contribution to journalArticle

Open Access
File
Catenins
Epithelial-Mesenchymal Transition
Dinoprostone
Cyclic AMP
Adherens Junctions
2015

Adhesion and migration of cells responding to microtopography

Estévez, M., Martínez, E., Yarwood, S. J., Dalby, M. J. & Samitier, J., May 2015, In : Journal of Biomedical Materials Research Part A. 103, 5, p. 1659-1668 10 p.

Research output: Contribution to journalArticle

Cell Adhesion
Cell Movement
Protein Kinase C
Fibroblasts
Cell Nucleus

Phosphorylation of ezrin on Thr567 is required for the synergistic activation of cell spreading by EPAC1 and protein kinase A in HEK293T cells

Parnell, E., Koschinski, A., Zaccolo, M., Cameron, R. T., Baillie, G. S., Baillie, G. L., Porter, A., McElroy, S. P. & Yarwood, S. J., Jul 2015, In : Biochimica et Biophysica Acta. 1853, 7, p. 1749-1758 10 p.

Research output: Contribution to journalArticle

Open Access
File
Cyclic AMP-Dependent Protein Kinases
Phosphorylation
Transfection
ezrin
Actins

Regulation of anti-inflammatory gene expression in vascular endothelial cells by EPAC1

Palmer, T. M. & Yarwood, S. J., 9 Nov 2015, In : Journal of Cell Signaling. 1, 1, 1000103.

Research output: Contribution to journalArticle

Open Access
File
Anti-Inflammatory Agents
Endothelial Cells
Cytokines
Gene Expression
Tunica Intima

Serine-727 phosphorylation activates hypothalamic STAT-3 independently from tyrosine-705 phosphorylation

Breit, A., Besik, V., Solinski, H. J., Muehlich, S., Glas, E., Yarwood, S. J. & Gudermann, T., Mar 2015, In : Molecular Endocrinology. 29, 3, p. 445-459 15 p.

Research output: Contribution to journalArticle

STAT3 Transcription Factor
Serine
Phosphorylation
Epidermal Growth Factor
Bradykinin

The cAMP sensors, EPAC1 and EPAC2, display distinct subcellular distributions despite sharing a common nuclear pore localisation signal

Parnell, E., Smith, B. O. & Yarwood, S. J., May 2015, In : Cellular Signalling. 27, 5, p. 989-996 8 p.

Research output: Contribution to journalArticle

Open Access
Nuclear Pore
Nuclear Localization Signals
Protein Isoforms
Structural Models
Catalytic Domain

The future of EPAC-targeted therapies: agonism versus antagonism

Parnell, E., Palmer, T. M. & Yarwood, S. J., Apr 2015, In : Trends in Pharmacological Sciences. 36, 4, p. 203-214 12 p.

Research output: Contribution to journalArticle

Open Access
Protein Isoforms
Proteins
Cyclic AMP-Dependent Protein Kinases
Treatment Failure
Blood Vessels
2014

Interactions between Epac1 and ezrin in the control of endothelial barrier function

Parnell, E. & Yarwood, S. J., Apr 2014, In : Biochemical Society Transactions. 42, 2, p. 274-278 5 p.

Research output: Contribution to journalArticle

Cyclic AMP-Dependent Protein Kinases
Actin Cytoskeleton
Endothelium
Cardiovascular Diseases
Proteins

Nanotopology potentiates growth hormone signalling and osteogenesis of mesenchymal stem cells

Wang, J. R., Ahmed, S. F., Gadegaard, N., Meek, R. M. D., Dalby, M. J. & Yarwood, S. J., Dec 2014, In : Growth Hormone and IGF Research. 24, 6, p. 245-250 6 p.

Research output: Contribution to journalArticle

Mesenchymal Stromal Cells
Osteogenesis
Growth Hormone
Somatotropin Receptors
Bone Development

Targeting SOCS proteins to combat inflammation

Yarwood, S., 2014, In : Endocrine Abstracts. 34 , S8.2

Research output: Contribution to journalArticle

The role of c-Jun in controlling the EPAC1-dependent induction of the SOCS3 gene in HUVECs

Wiejak, J., Dunlop, J. & Yarwood, S. J., 2 May 2014, In : FEBS Letters. 588, 9, p. 1556-1561 6 p.

Research output: Contribution to journalArticle

Cyclic AMP
Genes
Cyclic AMP-Dependent Protein Kinases
Fibroblasts
Phosphorylation
2013
STAT3 Transcription Factor
Transcriptional Activation
Interleukin-6
flavone
Endothelial Cells

Genomic analysis of the role of transcription factor C/EBPδ in the regulation of cell behaviour on nanometric grooves

Wiejak, J., Tsimbouri, P. M., Herzyk, P., Dalby, M. J., Hamilton, G. & Yarwood, S. J., Mar 2013, In : Biomaterials. 34, 8, p. 1967-1979 13 p.

Research output: Contribution to journalArticle

Open Access
Transcription Factors
Genes
Binding Sites
Gene Expression
Microarray Analysis

Modulation of mesenchymal stem cell differentiation by alterations in GH action and cell-matrix interaction

Wang, R. J., Yarwood, S., Dalby, M. & Ahmed, F., 2013, In : Endocrine Abstracts. 33, P65

Research output: Contribution to journalArticle

2012
Sp3 Transcription Factor
STAT3 Transcription Factor
Extracellular Signal-Regulated MAP Kinases
Mitogen-Activated Protein Kinases
Transcription Factor AP-1

Novel control of cAMP-regulated transcription in vascular endothelial cells

Milne, G. R., Palmer, T. M. & Yarwood, S. J., Feb 2012, In : Biochemical Society Transactions. 40, 1, p. 1-5 5 p.

Research output: Contribution to journalArticle

Endothelial Cells
Cytokines
Interleukin-6
Atherosclerosis
Cholesterol

Regulation of the inflammatory response of vascular endothelial cells by EPAC1

Parnell, E., Smith, B. O., Palmer, T. M., Terrin, A., Zaccolo, M. & Yarwood, S. J., May 2012, In : British Journal of Pharmacology. 166, 2, p. 434-446 13 p.

Research output: Contribution to journalArticle

Cyclic AMP
Endothelial Cells
Anti-Inflammatory Agents
Inflammation
Blood Vessels

The protein kinase C inhibitor, Ro-31-7459, is a potent activator of ERK and JNK MAP kinases in HUVECs and yet inhibits cyclic AMP-stimulated SOCS-3 gene induction through inactivation of the transcription factor c-Jun

Wiejak, J., Dunlop, J., Stoyle, C., Lappin, G., McIlroy, A., Pediani, J. D., Gao, S. & Yarwood, S. J., Aug 2012, In : Cellular Signalling. 24, 8, p. 1690-1699 10 p.

Research output: Contribution to journalArticle

Open Access
MAP Kinase Kinase 4
Protein C Inhibitor
Extracellular Signal-Regulated MAP Kinases
Protein Kinase Inhibitors
Cyclic AMP
2010
Phosphoric Diester Hydrolases
Protein Kinase C
Hydrolysis
Isoproterenol
Phosphodiesterase 4 Inhibitors
2009
CCAAT-Enhancer-Binding Protein-beta
Cyclic AMP
Protein Kinases
Protein Kinase C
Adenylate Kinase

EPAC proteins transduce diverse cellular actions of cAMP

Borland, G., Smith, B. O. & Yarwood, S. J., Sep 2009, In : British Journal of Pharmacology. 158, 1, p. 70-86 17 p.

Research output: Contribution to journalArticle

Cyclic AMP
Proteins
Anti-Inflammatory Agents
Cyclic Nucleotide-Gated Cation Channels
Pharmaceutical Preparations

Mimitin - a novel cytokine-regulated mitochondrial protein

Wegrzyn, P., Yarwood, S. J., Fiegler, N., Bzowska, M., Koj, A., Mizgalska, D., Malicki, S., Pajak, M., Kasza, A., Kachamakova-Trojanowska, N., Bereta, J., Jura, J. & Jura, J., 2009, In : BMC Cell Biology . 10, 23.

Research output: Contribution to journalArticle

Open Access
Mitochondrial Proteins
Cytokines
Hep G2 Cells
Apoptosis
Caspase 7

Selective inhibition of cytokine-activated extracellular signal-regulated kinase by cyclic AMP via Epac1-dependent induction of suppressor of cytokine signalling-3

Woolson, H. D., Thomson, V. S., Rutherford, C., Yarwood, S. J. & Palmer, T. M., Nov 2009, In : Cellular Signalling. 21, 11, p. 1706-1715 10 p.

Research output: Contribution to journalArticle

Extracellular Signal-Regulated MAP Kinases
Cyclic AMP
Cytokines
Proteins
Interleukin-6
2008

Identification of CCAAT/enhancer-binding proteins as exchange protein activated by cAMP-activated transcription factors that mediate the induction of the SOCS-3 gene

Yarwood, S. J., Borland, G., Sands, W. A. & Palmer, T. M., 14 Mar 2008, In : Journal of Biological Chemistry. 283, 11, p. 6843-6853 11 p.

Research output: Contribution to journalArticle

CCAAT-Enhancer-Binding Proteins
Transcription Factors
CCAAT-Enhancer-Binding Protein-beta
Cytokines
Genes

The effect of the RACK1 signalling protein on the regulation of cell adhesion and cell contact guidance on nanometric grooves

Dalby, M. J., Hart, A. & Yarwood, S. J., Jan 2008, In : Biomaterials. 29, 3, p. 282-289 8 p.

Research output: Contribution to journalArticle

Cell Adhesion
Stress Fibers
Proteins
Focal Adhesions
Antisense Oligonucleotides
2006

Microtubule-associated protein 1B-light chain 1 enhances activation of Rap1 by exchange protein activated by cyclic AMP but not intracellular targeting

Borland, G., Gupta, M., Magiera, M. M., Rundell, C. J., Fuld, S. & Yarwood, S. J., Jan 2006, In : Molecular Pharmacology. 69, 1, p. 374-384 11 p.

Research output: Contribution to journalArticle

Cyclic AMP
Light
Proteins
Catalytic Domain
Molecular Chaperones

RACK 1 associated with focal adhesions alters the cells sensitivity to contact guidance

Hart, A., Yarwood, S. & Dalby, M. J., Jun 2006, In : European Cells and Materials . 11, Supplement 2, p. 80 1 p.

Research output: Contribution to journalArticle

2005
Jurkat Cells
Cyclic AMP-Dependent Protein Kinases
Cyclic AMP
T-Lymphocytes
Proteins
GTP Phosphohydrolases
Cell Adhesion
Cyclic AMP
Light
Proteins
Microtubule-Associated Proteins
Proteins
Light
Cell Shape
GTP Phosphohydrolases
2004

Effect of cellular uptake of gelatin nanoparticles on adhesion, morphology and cytoskeleton organisation of human fibroblasts

Gupta, A. K., Gupta, M., Yarwood, S. J. & Curtis, A. S. G., 5 Mar 2004, In : Journal of Controlled Release. 95, 2, p. 197-207 11 p.

Research output: Contribution to journalArticle

Gelatin
Cytoskeleton
Nanoparticles
Fibroblasts
Transmission Electron Microscopy

Exchange protein directly activated by cAMP (EPAC) interacts with the light chain (LC) 2 of MAP1A

Magiera, M. M., Gupta, M., Rundell, C. J., Satish, N., Ernens, I. & Yarwood, S. J., 15 Sep 2004, In : Biochemical Journal. 382, 3, p. 803-810 8 p.

Research output: Contribution to journalArticle

Microtubule-Associated Proteins
Light
Proteins
Two-Hybrid System Techniques
Kidney

Protease inhibitors prevent the protein kinase A-dependent loss of Rap1 GTPase from the particulate fraction of COS1 cells

Rundell, C. J., Repellin, C. E. & Yarwood, S. J., 19 Mar 2004, In : Biochemical and Biophysical Research Communications. 315, 4, p. 1077-1081 5 p.

Research output: Contribution to journalArticle

GTP Phosphohydrolases
Cyclic AMP-Dependent Protein Kinases
Protease Inhibitors
Cyclic AMP
Monoclonal Antibodies
2003

Nucleus alignment and cell signaling in fibroblasts: response to a micro-grooved topography

Dalby, M. J., Riehle, M. O., Yarwood, S. J., Wilkinson, C. D. W. & Curtis, A. S. G., 1 Apr 2003, In : Experimental Cell Research. 284, 2, p. 274-282 9 p.

Research output: Contribution to journalArticle

Cell Nucleus
Fibroblasts
Genes
Cell Engineering
Embryology

Preparation and in vitro evaluation of pullulan nanoparticles as gene transfection system

Gupta, M., Gupta, A. K., Curtis, A. S. G. & Yarwood, S., Sep 2003, In : European Cells and Materials . 6, Supplement 2, p. 39 1 p.

Research output: Contribution to journalArticle

2002

Delineation of RAID1, the RACK1 interaction domain located within the unique N-terminal region of the cAMP-specific phosphodiesterase, PDE4D5

Bolger, G. B., McCahill, A., Yarwood, S. J., Steele, M. R., Warwicker, J. & Houslay, M. D., 2002, In : BMC Biochemistry. 3, 24.

Research output: Contribution to journalArticle

Open Access
Phosphoric Diester Hydrolases
Proteins
COS Cells
Mutagenesis
Alanine

Fibroblast signaling events in response to nanotopography: a gene array study

Dalby, M. J., Yarwood, S. J., Johnstone, H. J. H., Affrossman, S. & Riehle, M. O., Mar 2002, In : IEEE Transactions on NanoBioscience. 1, 1, p. 12-17 6 p.

Research output: Contribution to journalArticle

Fibroblasts
Islands
Genes
Protein Biosynthesis
Biocompatible Materials

In addition to the SH3 binding region, multiple regions within the N-terminal noncatalytic portion of the cAMP-specific phosphodiesterase, PDE4A5, contribute to its intracellular targeting

Beard, M. B., Huston, E., Campbell, L., Gall, I., McPhee, I., Yarwood, S., Scotland, G. & Houslay, M. D., May 2002, In : Cellular Signalling. 14, 5, p. 453-465 13 p.

Research output: Contribution to journalArticle

Phosphoric Diester Hydrolases
Cyclic AMP
Protein Isoforms
Membranes
src Homology Domains

Increasing fibroblast response to materials using nanotopography: morphological and genetic measurements of cell response to 13-nm-high polymer demixed islands

Dalby, M. J., Yarwood, S. J., Riehle, M. O., Johnstone, H. J. H., Affrossman, S. & Curtis, A. S. G., 15 May 2002, In : Experimental Cell Research. 276, 1, p. 1-9 9 p.

Research output: Contribution to journalArticle

Islands
Polymers
Fibroblasts
Extracellular Matrix Proteins
Polystyrenes

Polymer demixed nano-Topography: Random islands give an ordered response from human fibroblasts

Dalby, M. J., Riehle, M. O., Yarwood, S., Johnstone, H. J. H., Affrossman, S. & Curtis, A. S. G., Dec 2002, In : European Cells and Materials . 4, Supplement 2, p. 47-49 3 p.

Research output: Contribution to journalArticle