19952020

Research output per year

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Research Output

2020

Mechanism of Action of an EPAC1-Selective Competitive Partial Agonist

Shao, H., Mohamed, H., Boulton, S., Huang, J., Wang, P., Chen, H., Zhou, J., Luchowska-Stańska, U., Jentsch, N. G., Armstrong, A. L., Magolan, J., Yarwood, S. & Melacini, G., 14 May 2020, In : Journal of Medicinal Chemistry. 63, 9, p. 4762-4775 14 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Synthesis and Biochemical Evaluation of Noncyclic Nucleotide Exchange Proteins Directly Activated by cAMP 1 (EPAC1) Regulators

Wang, P., Luchowska-Stańska, U., Van Basten, B., Chen, H., Liu, Z., Wiejak, J., Whelan, P., Morgan, D., Lochhead, E., Barker, G., Rehmann, H., Yarwood, S. J. & Zhou, J., 28 May 2020, In : Journal of Medicinal Chemistry. 63, 10, p. 5159–5184 26 p.

Research output: Contribution to journalArticle

2019

Genome-Wide Mapping Defines a Role for C/EBPβ and c-Jun in Non-Canonical Cyclic AMP Signalling

Wiejak, J., van Basten, B., Hamilton, G. & Yarwood, S. J., 14 Oct 2019, In : Cells. 8, 10, 1253.

Research output: Contribution to journalArticle

Open Access
File
6 Downloads (Pure)

Identification of A Novel Class of Benzofuran Oxoacetic Acid-Derived Ligands that Selectively Activate Cellular EPAC1

Beck, E. M., Parnell, E., Cowley, A., Porter, A., Gillespie, J., Robinson, J., Robinson, L., Pannifer, A. D., Hamon, V., Jones, P., Morrison, A., McElroy, S., Timmerman, M., Rutjes, H., Mahajan, P., Wiejak, J., Luchowska-Stańska, U., Morgan, D., Barker, G., Rehmann, H. & 1 others, Yarwood, S. J., 12 Nov 2019, In : Cells. 8, 11, 1425.

Research output: Contribution to journalArticle

Open Access
File
5 Downloads (Pure)

Selective small-molecule EPAC activators

Luchowska-Stańska, U., Morgan, D., Yarwood, S. J. & Barker, G., 11 Oct 2019, In : Biochemical Society Transactions. 47, 5, p. 1415-1427 13 p.

Research output: Contribution to journalArticle

Open Access
File
34 Downloads (Pure)
Open Access
File
4 Citations (Scopus)
22 Downloads (Pure)
2017

Identification of a Novel, Small Molecule Partial Agonist for the Cyclic AMP Sensor, EPAC1

Parnell, E., McElroy, S. P., Wiejak, J., Baillie, G. L., Porter, A., Adams, D. R., Rehmann, H., Smith, B. O. & Yarwood, S. J., 22 Mar 2017, In : Scientific Reports. 7, 294.

Research output: Contribution to journalArticle

Open Access
File
10 Citations (Scopus)
50 Downloads (Pure)

Metformin suppresses adipogenesis through both AMP-activated protein kinase (AMPK)-dependent and AMPK-independent mechanisms

Chen, S. C., Brooks, R., Houskeeper, J., Bremner, S. K., Dunlop, J., Viollet, B., Logan, P. J., Salt, I. P., Ahmed, S. F. & Yarwood, S. J., 15 Jan 2017, In : Molecular and Cellular Endocrinology. 440, p. 57–68 12 p.

Research output: Contribution to journalArticle

Open Access
File
43 Citations (Scopus)
76 Downloads (Pure)

Nanotopography controls cell cycle changes involved with skeletal stem cell self-renewal and multipotency

Lee, L. C. Y., Gadegaard, N., De Andrés, M. C., Turner, L-A., Burgess, K. E. V., Yarwood, S. J., Wells, J., Salmeron-Sanchez, M., Meek, R. M. D., Oreffo, R. O. C. & Dalby, M. J., Feb 2017, In : Biomaterials. 116, p. 10-20 11 p.

Research output: Contribution to journalArticle

Open Access
File
28 Citations (Scopus)
34 Downloads (Pure)

Probe-dependent negative allosteric modulators of the long-chain free fatty acid receptor FFA4

Watterson, K. R., Hansen, S. V. F., Hudson, B., Alvarez-Curto, E., Raihan, S. Z., Azevedo, C. M. G., Martin, G., Dunlop, J., Yarwood, S. J., Ulven, T. & Milligan, G., 1 Jun 2017, In : Molecular Pharmacology. 91, 6, p. 630-641 12 p.

Research output: Contribution to journalArticle

Open Access
File
12 Citations (Scopus)
20 Downloads (Pure)
Open Access
File
3 Citations (Scopus)
46 Downloads (Pure)

The Potential of a Novel Class of EPAC-Selective Agonists to Combat Cardiovascular Inflammation

Barker, G., Parnell, E., Van Basten, B., Buist, H., Adams, D. R. & Yarwood, S. J., 5 Dec 2017, In : Journal of Cardiovascular Disease and Development. 4, 4, p. 22-37 16 p.

Research output: Contribution to journalLiterature review

Open Access
File
32 Downloads (Pure)
2016

Dynamic Surfaces for the Study of Mesenchymal Stem Cell Growth through Adhesion Regulation

Roberts, J. N., Sahoo, J. K., Mcnamara, L. E., Burgess, K. E. V., Yang, J., Alakpa, E. V., Anderson, H. J., Hay, J., Turner, L-A., Yarwood, S. J., Zelzer, M., Oreffo, R. O. C., Ulijn, R. V. & Dalby, M. J., Jul 2016, In : ACS Nano.

Research output: Contribution to journalArticle

Open Access
File
45 Citations (Scopus)
41 Downloads (Pure)

Epac1 links prostaglandin E2 to β-catenin-dependent transcription during epithelial-to-mesenchymal transition

Jansen, S. R., Poppinga, W. J., De Jager, W., Lezoualc'h, F., Cheng, X., Wieland, T., Yarwood, S., Gosens, R. & Schmidt, M., Jul 2016, In : Oncotarget. 7, 29

Research output: Contribution to journalArticle

Open Access
File
11 Citations (Scopus)
33 Downloads (Pure)

Epac1 links prostaglandin E2 to β-catenin transcriptional activity during epithelial-to-mesenchymal transition in A549 cells

Jansen, S., De Jager, W., Yarwood, S. J., Lezoualc’h, F., Gosens, R. & Schmidt, M., Apr 2016, In : The FASEB Journal. 30, 1 Supplement, 714.5.

Research output: Contribution to journalMeeting abstract

Metformin regulates the differentiation of murine mesenchymal stem cells via AMPK-independent suppression of p70s6-kinase

Chen, S. C., Brooks, R., Ahmed, S. F. & Yarwood, S. J., Mar 2016, In : Diabetic Medicine. 33, Supplement S1, p. 32-32 1 p.

Research output: Contribution to journalMeeting abstract

2 Citations (Scopus)
2015

Adhesion and migration of cells responding to microtopography

Estévez, M., Martínez, E., Yarwood, S. J., Dalby, M. J. & Samitier, J., May 2015, In : Journal of Biomedical Materials Research Part A. 103, 5, p. 1659-1668 10 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)

Phosphorylation of ezrin on Thr567 is required for the synergistic activation of cell spreading by EPAC1 and protein kinase A in HEK293T cells

Parnell, E., Koschinski, A., Zaccolo, M., Cameron, R. T., Baillie, G. S., Baillie, G. L., Porter, A., McElroy, S. P. & Yarwood, S. J., Jul 2015, In : Biochimica et Biophysica Acta. 1853, 7, p. 1749-1758 10 p.

Research output: Contribution to journalArticle

Open Access
File
9 Citations (Scopus)
18 Downloads (Pure)

Regulation of anti-inflammatory gene expression in vascular endothelial cells by EPAC1

Palmer, T. M. & Yarwood, S. J., 9 Nov 2015, In : Journal of Cell Signaling. 1, 1, 1000103.

Research output: Contribution to journalArticle

Open Access
File
33 Downloads (Pure)

Serine-727 phosphorylation activates hypothalamic STAT-3 independently from tyrosine-705 phosphorylation

Breit, A., Besik, V., Solinski, H. J., Muehlich, S., Glas, E., Yarwood, S. J. & Gudermann, T., Mar 2015, In : Molecular Endocrinology. 29, 3, p. 445-459 15 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

The cAMP sensors, EPAC1 and EPAC2, display distinct subcellular distributions despite sharing a common nuclear pore localisation signal

Parnell, E., Smith, B. O. & Yarwood, S. J., May 2015, In : Cellular Signalling. 27, 5, p. 989-996 8 p.

Research output: Contribution to journalArticle

Open Access
14 Citations (Scopus)

The future of EPAC-targeted therapies: agonism versus antagonism

Parnell, E., Palmer, T. M. & Yarwood, S. J., Apr 2015, In : Trends in Pharmacological Sciences. 36, 4, p. 203-214 12 p.

Research output: Contribution to journalArticle

Open Access
44 Citations (Scopus)
2014

Improving effectiveness of nanotopography for mesenchymal stem cell growth

Lee, L. C., Gadegaard, N., Yarwood, S., Meek, R. M. D. & Dalby, M. J., Jun 2014, In : Journal of Tissue Engineering and Regenerative Medicine. 8, s1, p. 287-287 1 p.

Research output: Contribution to journalMeeting abstract

23 Citations (Scopus)

Interactions between Epac1 and ezrin in the control of endothelial barrier function

Parnell, E. & Yarwood, S. J., Apr 2014, In : Biochemical Society Transactions. 42, 2, p. 274-278 5 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Nanotopology potentiates growth hormone signalling and osteogenesis of mesenchymal stem cells

Wang, J. R., Ahmed, S. F., Gadegaard, N., Meek, R. M. D., Dalby, M. J. & Yarwood, S. J., Dec 2014, In : Growth Hormone and IGF Research. 24, 6, p. 245-250 6 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)

Targeting SOCS proteins to combat inflammation

Yarwood, S., 2014, In : Endocrine Abstracts. 34 , S8.2

Research output: Contribution to journalArticle

The role of c-Jun in controlling the EPAC1-dependent induction of the SOCS3 gene in HUVECs

Wiejak, J., Dunlop, J. & Yarwood, S. J., 2 May 2014, In : FEBS Letters. 588, 9, p. 1556-1561 6 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

The role of the AMPK pathway in mediating the effects of metformin on mesenchymal stem cell differentiation

Chen, S. C., Brooks, R., Ahmed, S. F. & Yarwood, S. J., 2014, In : Endocrine Abstracts. 36, OC6.4.

Research output: Contribution to journalMeeting abstract

2013
25 Citations (Scopus)

Genomic analysis of the role of transcription factor C/EBPδ in the regulation of cell behaviour on nanometric grooves

Wiejak, J., Tsimbouri, P. M., Herzyk, P., Dalby, M. J., Hamilton, G. & Yarwood, S. J., Mar 2013, In : Biomaterials. 34, 8, p. 1967-1979 13 p.

Research output: Contribution to journalArticle

Open Access
5 Citations (Scopus)

Modulation of mesenchymal stem cell differentiation by alterations in GH action and cell-matrix interaction

Wang, R. J., Yarwood, S., Dalby, M. & Ahmed, F., 2013, In : Endocrine Abstracts. 33, P65

Research output: Contribution to journalArticle

2012

Exchange protein directly activated by cyclic AMP-1-regulated recruitment of CCAAT/enhancer-binding proteins to the suppressor of cytokine signaling-3 promoter

Sands, W. A., Woolson, H. D., Yarwood, S. J. & Palmer, T. M., 2012, Transcriptional Regulation: Methods and Protocols. Vancura, A. (ed.). Vol. 809. p. 201-214 14 p. (Methods in Molecular Biology; vol. 809).

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

4 Citations (Scopus)
12 Citations (Scopus)

Novel control of cAMP-regulated transcription in vascular endothelial cells

Milne, G. R., Palmer, T. M. & Yarwood, S. J., Feb 2012, In : Biochemical Society Transactions. 40, 1, p. 1-5 5 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Regulation of the inflammatory response of vascular endothelial cells by EPAC1

Parnell, E., Smith, B. O., Palmer, T. M., Terrin, A., Zaccolo, M. & Yarwood, S. J., May 2012, In : British Journal of Pharmacology. 166, 2, p. 434-446 13 p.

Research output: Contribution to journalArticle

36 Citations (Scopus)

The protein kinase C inhibitor, Ro-31-7459, is a potent activator of ERK and JNK MAP kinases in HUVECs and yet inhibits cyclic AMP-stimulated SOCS-3 gene induction through inactivation of the transcription factor c-Jun

Wiejak, J., Dunlop, J., Stoyle, C., Lappin, G., McIlroy, A., Pediani, J. D., Gao, S. & Yarwood, S. J., Aug 2012, In : Cellular Signalling. 24, 8, p. 1690-1699 10 p.

Research output: Contribution to journalArticle

Open Access
5 Citations (Scopus)
2010
26 Citations (Scopus)
2009
43 Citations (Scopus)

EPAC proteins transduce diverse cellular actions of cAMP

Borland, G., Smith, B. O. & Yarwood, S. J., Sep 2009, In : British Journal of Pharmacology. 158, 1, p. 70-86 17 p.

Research output: Contribution to journalArticle

99 Citations (Scopus)

Mimitin - a novel cytokine-regulated mitochondrial protein

Wegrzyn, P., Yarwood, S. J., Fiegler, N., Bzowska, M., Koj, A., Mizgalska, D., Malicki, S., Pajak, M., Kasza, A., Kachamakova-Trojanowska, N., Bereta, J., Jura, J. & Jura, J., 2009, In : BMC Cell Biology . 10, 23.

Research output: Contribution to journalArticle

Open Access
12 Citations (Scopus)

Selective inhibition of cytokine-activated extracellular signal-regulated kinase by cyclic AMP via Epac1-dependent induction of suppressor of cytokine signalling-3

Woolson, H. D., Thomson, V. S., Rutherford, C., Yarwood, S. J. & Palmer, T. M., Nov 2009, In : Cellular Signalling. 21, 11, p. 1706-1715 10 p.

Research output: Contribution to journalArticle

37 Citations (Scopus)
2008

Identification of CCAAT/enhancer-binding proteins as exchange protein activated by cAMP-activated transcription factors that mediate the induction of the SOCS-3 gene

Yarwood, S. J., Borland, G., Sands, W. A. & Palmer, T. M., 14 Mar 2008, In : Journal of Biological Chemistry. 283, 11, p. 6843-6853 11 p.

Research output: Contribution to journalArticle

61 Citations (Scopus)

Regulation of anti-inflammatory signalling by Epac in vascular endothelial cells

Yarwood, S., Borland, G. & Bird, R. J., Aug 2008, In : Fundamental and Clinical Pharmacology. 22, s2, p. 25-25 1 p.

Research output: Contribution to journalMeeting abstract

18 Citations (Scopus)

The effect of the RACK1 signalling protein on the regulation of cell adhesion and cell contact guidance on nanometric grooves

Dalby, M. J., Hart, A. & Yarwood, S. J., Jan 2008, In : Biomaterials. 29, 3, p. 282-289 8 p.

Research output: Contribution to journalArticle

47 Citations (Scopus)
2007

Analysis of focal adhesions and cytoskeleton by custom microarray

Dalby, M. J. & Yarwood, S. J., 2007, Adhesion Protein Protocols. Coutts, A. S. (ed.). Humana Press, p. 121-134 14 p. (Methods in Molecular Biology; vol. 370).

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

5 Citations (Scopus)

Cyclic AMP-mediated induction of suppressor of cytokine signalling-3 (SOCS3) through EPAC1 and C/EBP transcription factors

Borland, G., Yarwood, S., Sands, W. A. & Palmer, T. M., 2007, In : Proceedings of the Physiological Society.

Research output: Contribution to journalMeeting abstract

2006

Microtubule-associated protein 1B-light chain 1 enhances activation of Rap1 by exchange protein activated by cyclic AMP but not intracellular targeting

Borland, G., Gupta, M., Magiera, M. M., Rundell, C. J., Fuld, S. & Yarwood, S. J., Jan 2006, In : Molecular Pharmacology. 69, 1, p. 374-384 11 p.

Research output: Contribution to journalArticle

36 Citations (Scopus)

RACK 1 associated with focal adhesions alters the cells sensitivity to contact guidance

Hart, A., Yarwood, S. & Dalby, M. J., Jun 2006, In : European Cells and Materials . 11, Supplement 2, p. 80 1 p.

Research output: Contribution to journalArticle

2005
28 Citations (Scopus)
31 Citations (Scopus)