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Research Output

  • 51 Article
  • 3 Conference contribution
  • 2 Other
  • 1 Chapter (peer-reviewed)
2019

A VPS33A-binding motif on syntaxin17 controls autophagy completion in mammalian cells

Saleeb, R. S., Kavanagh, D. M., Dun, A. R., Dalgarno, P. A. & Duncan, R. R., 15 Mar 2019, In : Journal of Biological Chemistry. 294, 11, p. 4188-4201 14 p.

Research output: Contribution to journalArticle

Open Access
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31 Downloads (Pure)

Fluorescence lifetime imaging of high-speed particles with single-photon image sensors

Gyongy, I., Green, A., Hutchings, S. W., Davies, A., Dutton, N. A. W., Duncan, R. R., Rickman, C., Henderson, R. K. & Dalgarno, P. A., 4 Mar 2019, High-Speed Biomedical Imaging and Spectroscopy IV. Tsia, K. K. & Goda, K. (eds.). SPIE, 108890O. (Proceedings of SPIE; vol. 10889).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

High fidelity fibre-based physiological sensing deep in tissue

Choudhary, T., Tanner, M. G., Megia-Fernandez, A., Harrington, K., Wood, H. A. C., Marshall, A., Zhu, P., Chankeshwara, S. V., Choudhury, D., Monro, G., Ucuncu, M., Yu, F., Duncan, R. R., Thomson, R. R., Dhaliwal, K. & Bradley, M., 22 May 2019, In : Scientific Reports. 9, 7713.

Research output: Contribution to journalArticle

Open Access
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9 Downloads (Pure)

SWAP70 undergoes dynamic conformational regulation at the leading edge of migrating cells

Kriplani, N., Duncan, R. R. & Leslie, N. R., Feb 2019, In : FEBS Letters. 593, 4, p. 395-405 11 p.

Research output: Contribution to journalArticle

Open Access
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2018

A 256 x 256, 100-kfps, 61% Fill-Factor SPAD Image Sensor for Time-Resolved Microscopy Applications

Gyongy, I., Calder, N., Davies, A., Dutton, N. A. W., Duncan, R. R., Rickman, C., Dalgarno, P. A. & Henderson, R. K., Feb 2018, In : IEEE Transactions on Electron Devices. 65, 2, p. 547-554 8 p.

Research output: Contribution to journalArticle

Open Access
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526 Downloads (Pure)

A catch-and-release approach to selective modification of accessible tyrosine residues

Allan, C., Kosar, M., Burr, C. V., Mackay, C. L., Duncan, R. R. & Hulme, A. N., 13 Sep 2018, In : ChemBioChem.

Research output: Contribution to journalArticle

Open Access
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9 Downloads (Pure)

Cylindrical microlensing for enhanced collection efficiency of small pixel SPAD arrays in single-molecule localisation microscopy

Gyongy, I., Davies, A., Gallinet, B., Dutton, N. A. W., Duncan, R. R., Rickman, C., Henderson, R. K. & Dalgarno, P. A., 5 Feb 2018, In : Optics Express. 26, 3, p. 2280-2291 12 p.

Research output: Contribution to journalArticle

Open Access
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45 Downloads (Pure)

High-speed particle tracking in microscopy using SPAD image sensors

Gyongy, I., Davies, A., Miguelez Crespo, A., Green, A., Dutton, N. A. W., Duncan, R. R., Rickman, C., Henderson, R. K. & Dalgarno, P. A., 20 Feb 2018, High-Speed Biomedical Imaging and Spectroscopy III: Toward Big Data Instrumentation and Management. Tsia, K. K. & Goda, K. (eds.). Vol. 105050. 105050A. (Proceedings of SPIE; vol. 10505).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Open Access
File
71 Downloads (Pure)
2017

256×256, 100kfps, 61% Fill-factor time-resolved SPAD image sensor for microscopy applications

Gyongy, I., Calder, N., Davies, A., Dutton, N. A. W., Dalgarno, P. A., Duncan, R. R., Rickman, C. & Henderson, R. K., 2 Feb 2017, 2016 IEEE International Electron Devices Meeting (IEDM). IEEE, p. 8.2.1-8.2.4 4 p. (Technical digest).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Bimodal dynamics of granular organelles in primary renin-expressing cells revealed using TIRF microscopy

Buckley, C., Dun, A. R., Peter, A., Bellamy, C., Gross, K. W., Duncan, R. R. & Mullins, J. J., 9 Jan 2017, In : AJP - Renal Physiology . 312, 1, p. F200-F209 10 p.

Research output: Contribution to journalArticle

Open Access
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16 Downloads (Pure)

EnLightenment: High resolution smartphone microscopy as an educational and public engagement platform [version 1; referees: 2 approved]

Wicks, L. C., Cairns, G. S., Melnyk, J., Bryce, S., Duncan, R. R. & Dalgarno, P. A., 6 Nov 2017, In : Wellcome Open Research. 2, 107

Research output: Contribution to journalArticle

File
28 Downloads (Pure)

Glyoxal as an alternative fixative to formaldehyde in immunostaining and super-resolution microscopy

Richter, K. N., Revelo, N. H., Seitz, K. J., Helm, M. S., Sarkar, D., Saleeb, R. S., D'Este, E., Eberle, J., Wagner, E., Vogl, C., Lazaro, D. F., Richter, F., Coy-Vergara, J., Coceano, G., Boyden, E. S., Duncan, R. R., Hell, S. W., Lauterbach, M. A., Lehnart, S. E., Moser, T. & 6 others, Outeiro, T., Rehling, P., Schwappach, B., Testa, I., Zapiec, B. & Rizzoli, S. O., 1 Dec 2017, In : EMBO Journal. 36, 23, e201695709.

Research output: Contribution to journalArticle

Open Access
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45 Downloads (Pure)

Multiplexed fibre optic sensing in the distal lung (Conference Presentation)

Choudhary, T. R., Tanner, M. G., Megia-Fernandez, A., Harrington, K., Wood, H. A., Chankeshwara, S., Zhu, P., Choudhury, D., Yu, F., Thomson, R. R., Duncan, R. R., Dhaliwal, K. & Bradley, M., 19 Apr 2017, p. 100580E.

Research output: Contribution to conferenceOther

Navigation through the Plasma Membrane Molecular Landscape Shapes Random Organelle Movement

Dun, A., Lord, G. J., Wilson, R. S., Kavanagh, D., Cialowicz, K., Sugita, S., Park, S., Yang, L., Smyth, A. M., Papadopulos, A., Rickman, C. & Duncan, R. R., 6 Feb 2017, In : Current Biology. 27, 3, p. 408–414 7 p.

Research output: Contribution to journalArticle

Open Access
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57 Downloads (Pure)

SAF-A Regulates Interphase Chromosome Structure through Oligomerization with Chromatin-Associated RNAs

Nozawa, R-S., Boteva, L., Soares, D. C., Naughton, C., Dun, A. R., Buckle, A., Ramsahoye, B., Bruton, P. C., Saleeb, R. S., Arnedo, M., Hill, B., Duncan, R. R., Maciver, S. K. & Gilbert, N., 15 Jun 2017, In : Cell. 169, 7, p. 1214-1227 14 p.

Research output: Contribution to journalArticle

Open Access
File
25 Downloads (Pure)

Tryptophan and Non-Tryptophan Fluorescence of the Eye Lens Proteins Provides Diagnostics of Cataract at the Molecular Level

Gakamsky, A., Duncan, R. R., Howarth, N. M., Dhillon, B., Buttenschön, K. K., Daly, D. J. & Gakamsky, D., 10 Jan 2017, In : Scientific Reports. 7, 40375.

Research output: Contribution to journalArticle

Open Access
File
55 Downloads (Pure)
2016

Automated single particle detection and tracking for large microscopy datasets

Wilson, R. S., Yang, L., Dun, A., Smyth, A. M., Duncan, R. R., Rickman, C. & Lu, W., 1 May 2016, In : Royal Society Open Science. 3, 5, 160225.

Research output: Contribution to journalArticle

Open Access
File
50 Downloads (Pure)

Corrigendum: Translation Microscopy (TRAM) for super-resolution imaging

Qiu, Z., Wilson, R. S., Liu, Y., Dun, A. R., Saleeb, R. S., Liu, D., Rickman, C., Frame, M., Duncan, R. R. & Lu, W., 18 Mar 2016, In : Scientific Reports. 6, p. 22313

Research output: Contribution to journalArticle

Open Access
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9 Downloads (Pure)

PSD95 nanoclusters are postsynaptic building blocks in hippocampus circuits

Broadhead, M. J., Horrocks, M. H., Zhu, F., Muresan, L., Benavides-Piccione, R., DeFelipe, J., Fricker, D., Kopanitsa, M. V., Duncan, R., Klenerman, D., Komiyama, N. H., Lee, S. F. & Grant, S. G. N., 25 Apr 2016, In : Scientific Reports. 6, 24626.

Research output: Contribution to journalArticle

Open Access
File
42 Downloads (Pure)

Smart-aggregation imaging for single molecule localisation with SPAD cameras

Gyongy, I., Davies, A., Dutton, N. A. W., Duncan, R. R., Rickman, C., Henderson, R. K. & Dalgarno, P. A., 23 Nov 2016, In : Scientific Reports. 6, 37349.

Research output: Contribution to journalArticle

Open Access
File
33 Downloads (Pure)

Translation Microscopy (TRAM) for super-resolution imaging

Qiu, Z., Wilson, R. S., Liu, Y., Dun, A., Saleeb, R. S., Liu, D., Rickman, C., Frame, M., Duncan, R. & Lu, W., 29 Jan 2016, In : Scientific Reports. 6, 19993.

Research output: Contribution to journalArticle

Open Access
File
27 Downloads (Pure)
2015

Rapid formation of a supramolecular polypeptide-DNA Hydrogel for in situ three-dimensional multilayer bioprinting

Li, C., Faulkner-Jones, A., Dun, A. R., Jin, J., Chen, P., Xing, Y., Yang, Z., Li, Z., Shu, W., Liu, D. & Duncan, R. R., 23 Mar 2015, In : Angewandte Chemie International Edition. 54, 13, p. 3957-3961 5 p.

Research output: Contribution to journalArticle

Open Access
File
73 Downloads (Pure)
2014

A molecular toggle after exocytosis sequesters the presynaptic syntaxin1a molecules involved in prior vesicle fusion

Kavanagh, D., Smyth, A. M., Martin, K. J., Dun, A., Brown, E. R., Gordon, S., Smillie, K. J., Chamberlain, L. H., Wilson, R. S., Yang, L., Lu, W., Cousin, M. A., Rickman, C. & Duncan, R. R., 2014, In : Nature Communications. 5, 5774.

Research output: Contribution to journalArticle

Open Access
File
86 Downloads (Pure)

Functional, quantitative, and super-resolution imaging and spectroscopic approaches for studying exocytosis

Duncan, R. R. & Rickman, C., 2014, Exocytosis Methods. Vol. 83. p. 75-91 17 p. (Neuromethods).

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

2013

Femtosecond pumping of eGFP transfected human embryonic kidney cells

Mackenzie, M. D., Choudhury, D., Paterson, L., Duncan, R. & Kar, A. K., 2013, p. 1-2. 2 p.

Research output: Contribution to conferenceOther

Imaging large cohorts of single ion channels and their activity

Hiersemenzel, K., Brown, E. R. & Duncan, R. R., 2013, In : Frontiers in Endocrinology. 4, p. 114

Research output: Contribution to journalArticle

Open Access
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142 Downloads (Pure)

Munc 18-1 Protein Molecules Move between Membrane Molecular Depots Distinct from Vesicle Docking Sites

Smyth, A. M., Yang, L., Martin, K. J., Hamilton, C., Lu, W., Cousin, M. A., Rickman, C. & Duncan, R. R., 15 Feb 2013, In : Journal of Biological Chemistry. 288, 7, p. 5102-5113 12 p.

Research output: Contribution to journalArticle

Open Access
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147 Downloads (Pure)
2012

Secretory vesicles are preferentially targeted to areas of low molecular SNARE density

Yang, L., Dun, A., Martin, K. J., Qiu, Z., Dunn, A., Lord, G. J., Lu, W., Duncan, R. R. & Rickman, C., 2012, In : PLoS ONE. 7, 11, p. e49514

Research output: Contribution to journalArticle

Open Access
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73 Downloads (Pure)
2010

Munc18/syntaxin interaction kinetics control secretory vesicle dynamics

Rickman, C. & Duncan, R. R., 5 Feb 2010, In : Journal of Biological Chemistry. 285, 6, p. 3965-3972 8 p.

Research output: Contribution to journalArticle

Munc18-1 and syntaxin1: unraveling the interactions between the dynamic duo

Smyth, A. M., Duncan, R. R. & Rickman, C., 2010, In : Cellular and Molecular Neurobiology. 30, 8, p. 1309-13 5 p.

Research output: Contribution to journalArticle

The t-SNARE complex: a close up

Dun, A., Rickman, C. & Duncan, R. R., Nov 2010, In : Cellular and Molecular Neurobiology. 30, 8, p. 1321-1326 6 p.

Research output: Contribution to journalArticle

t-SNARE protein conformations patterned by the lipid microenvironment

Rickman, C., Medine, C. N., Dun, A. R., Moulton, D. J., Mandula, O., Halemani, N. D., Rizzoli, S. O., Chamberlain, L. H. & Duncan, R. R., 30 Apr 2010, In : Journal of Biological Chemistry. 285, 18, p. 13535-13541 7 p.

Research output: Contribution to journalArticle

Vesicle fusion probability is determined by the specific interactions of munc18

Smyth, A. M., Rickman, C. & Duncan, R. R., 3 Dec 2010, In : Journal of Biological Chemistry. 285, 49, p. 38141-38148 8 p.

Research output: Contribution to journalArticle

2009

Inhibiting pro-death NMDA receptor signaling dependent on the NR2 PDZ ligand may not affect synaptic function or synaptic NMDA receptor signaling to gene expression

Martel, M-A., Soriano, F. X., Baxter, P., Rickman, C., Duncan, R., Wyllie, D. J. A. & Hardingham, G. E., 2009, In : Channels. 3, 1, p. 12-15 4 p.

Research output: Contribution to journalArticle

In vivo FLIM-FRET measurements of recombinant proteins expressed in filamentous fungi

Altenbach, K., Duncan, R. R. & Valkonen, M., Aug 2009, In : Fungal Biology Reviews. 23, 3, p. 67-71 5 p.

Research output: Contribution to journalArticle

2008

S-nitrosylation of syntaxin 1 at Cys(145) is a regulatory switch controlling Munc18-1 binding.

Palmer, Z. J., Duncan, R., Johnson, J. R., Lian, L-Y., MELLO, L. V., Booth, D., Barclay, J. W., Graham, M. E., Burgoyne, R. D., Prior, I. A. & Morgan, A., 1 Aug 2008, In : Biochemical Journal. 413, 3, p. 479-491 12 p.

Research output: Contribution to journalArticle

Specific targeting of pro-death NMDA receptor signals with differing reliance on the NR2B PDZ ligand

Soriano, F. X., Martel, M-A., Papadia, S., Vaslin, A., Baxter, P., Rickman, C., Forder, J., Tymianski, M., Duncan, R., Aarts, M., Clarke, P., Wyllie, D. J. A. & Hardingham, G. E., 2008, In : Journal of Neuroscience Research. 28, 42, p. 10696-710 15 p.

Research output: Contribution to journalArticle

2007

Functionally and spatially distinct modes of munc18-syntaxin 1 interaction

Rickman, C., Medine, C. N., Bergmann, A. & Duncan, R. R., 20 Apr 2007, In : Journal of Biological Chemistry. 282, 16, p. 12097-12103 7 p.

Research output: Contribution to journalArticle

Munc18-1 prevents the formation of ectopic SNARE complexes in living cells

Medine, C. N., Rickman, C., Chamberlain, L. H. & Duncan, R. R., 15 Dec 2007, In : Journal of Cell Science. 120, 24, p. 4407-4415 9 p.

Research output: Contribution to journalArticle

Spatially segregated SNARE protein interactions in living fungal cells

Valkonen, M., Kalkman, E. R., Saloheimo, M., Penttilä, M., Read, N. D. & Duncan, R. R., 3 Aug 2007, In : Journal of Biological Chemistry. 282, 31, p. 22775-22785 11 p.

Research output: Contribution to journalArticle

Time-correlated single photon counting FLIM: Some considerations for physiologists

Medine, C. N., McDonald, A., Bergmann, A. & Duncan, R., May 2007, In : Microscopy Research and Technique. 70, 5, p. 420-425 6 p.

Research output: Contribution to journalArticle

2006
2004

An endochitinase A from Vibrio carchariae: cloning, expression, mass and sequence analyses, and chitin hydrolysis

Suginta, W., Vongsuwan, A., Songsiriritthigul, C., Prinz, H., Estibeiro, P., Duncan, R. R., Svasti, J. & Fothergill-Gilmore, L. A., 15 Apr 2004, In : Archives of Biochemistry and Biophysics. 424, 2, p. 171-180 10 p.

Research output: Contribution to journalArticle

Multi-dimensional time-correlated single photon counting (TCSPC) fluorescence lifetime imaging microscopy (FLIM) to detect FRET in cells

Duncan, R., Bergmann, A., Cousin, M. A., Apps, D. K. & Shipston, M. J., Jul 2004, In : Journal of Microscopy. 215, 1, p. 1-12 12 p.

Research output: Contribution to journalArticle

2003

Functional and spatial segregation of secretory vesicle pools according to vesicle age

Duncan, R. R., Greaves, J., Wiegand, U. K., Matskevich, I., Bodammer, G., Apps, D. K., Shipston, M. J. & Chow, R. H., 13 Mar 2003, In : Nature. 422, 6928, p. 176-180 5 p.

Research output: Contribution to journalArticle

Red, yellow, green go! - a novel tool for microscopic segregation of secretory vesicle pools according to their age

Wiegand, U. K., Duncan, R., Greaves, J., Chow, R. H., Shipston, M. J. & Apps, D. K., Aug 2003, In : Biochemical Society Transactions. 31, 4, p. 851-856 6 p.

Research output: Contribution to journalArticle

2002

Efficacy of Semliki Forest virus transduction of bovine adrenal chromaffin cells: an analysis of heterologous protein targeting and distribution

Duncan, R., Greaves, J., Tapechum, S., Apps, D. K., Shipston, M. J. & Chow, R. H., Oct 2002, In : Annals of the New York Academy of Sciences. 971, p. 641-646 6 p.

Research output: Contribution to journalArticle

Exocytosis studies in a chromaffin cell-free system: imaging of single-vesicle exocytosis in a chromaffin cell-free system using total internal reflection fluorescence microscopy

Wiegand, U. K., Don-Wauchope, A. C., Matskevich, I., Duncan, R. R., Greaves, J., Shipston, M. J., Apps, D. K. & Chow, R. H., Oct 2002, In : Annals of the New York Academy of Sciences. 971, p. 257-261 5 p.

Research output: Contribution to journalArticle

Use of ANF-EGFP for the visualization of secretory vesicles in bovine adrenal chromaffin cells

Greaves, J., Duncan, R. R., Tapechum, S., Apps, D. K., Shipston, M. J. & Chow, R. H., Oct 2002, In : Annals of the New York Academy of Sciences. 971, p. 275-276 2 p.

Research output: Contribution to journalArticle

2001

Alternative splicing switches potassium channel sensitivity to protein phosphorylation

Tian, L., Duncan, R., Hammond, M. S. L., Coghill, L. S., Wen, H., Rusinova, R., Clark, A. G., Levitan, I. B. & Shipston, M. J., 16 Mar 2001, In : Journal of Biological Chemistry. 276, 11, p. 7717-7720 4 p.

Research output: Contribution to journalArticle