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Personal profile

Biography

Rory Duncan (University Senior Academic Lead for Strategy and Development) was founding Head of the Institute of Biological chemistry, Biophysics and Bioengineering at Heriot-Watt University, applying advances in EPS to life science challenges. He is PI and Co-Director of the Edinburgh super-resolution imaging consortium (ESRIC, www.esric.org) with support from MRC/BBSRC/EPSRC and the Wellcome Trust, developing and applying super-resolution imaging modalities. This programme of work was awarded the Times Higher ‘STEM Research Project of the Year 2018/18’. 

Rory’s work spans many Disciplines and he has publications in leading biology, chemistry, engineering and physics journals, and he holds multiple patents. Rory sits on as is ad hocChair of STFC Science Board, the principal scientific advisory committee providing strategic oversight on all research activities for that Research Council and is part of the Accelerator International Strategic Review Panel, shaping strategy for the next 25 years. He is a member of the Scottish Parliamentary Cross-Party Group for Life Sciences. 

Rory has won several awards for science communication and was awarded the Royal Society of Edinburgh Senior Medal for Public Engagement in 2018 for his ‘passion and enormously productive advocacy for public engagement in Scotland, the UK and internationally’. His current role is as Senior Academic Lead for Strategy and Development for Heriot-Watt University as well as of Academic Lead for Public Engagement with Research. In the latter role, Rory holds external funds to develop public engagement strategy for the university with an emphasis on community engagement and embedding public engagement in university culture.

 

 

 

Research interests

My immediate research focus is on regulated secretion and membrane fusion. Over the last decade, we have established a series of cutting-edge functional and super-resolution imaging techniques that address membrane trafficking in living cells in real-time. This has led to a number of high-profile publications in the current REF period in international Journals including Nature, the EMBO JournalCurrent BiologyNature Communications and Cell. Much of this work was established using cell-lines and as such was technically advanced, but somewhat limiting in terms of cell biology discovery science.

Thus, at present, this research is being extended to use primary, human donor material – pancreatic islets. Islets are the multicellular organoid structures that synthesise and secrete insulin and other hormones, and if this becomes misregulated, it leads to Type 1 and Type 2 diabetes.

I work within a growing international collaboration with US, Canadian (Edmonton and Toronto), EU and Korean partners with privileged access to healthy, and Type 1 Diabetic islets. My focus for the next 5 years therefore is to quantify in 4-dimensions, the dynamics and interactions of SNARE proteins and other accessory factors in diseases such as diabetes and also in fundamental studies of autophagy. I employ a range of molecular biology, biochemical and optical imaging and spectroscopy approaches; the latter including world-leading super-resolution and functional imaging spectroscopies. This work is presently being extended with mathematicians and computer scientists to use machine learning and artificial intelligence techniques to predict the performance of pancreatic islets in vivo.

Roles & Responsibilities

External positions

Canadian Foundation for Innovation

Carnegie Trust for the Universities of Scotland

Science & Technology Facilities Council

University of Edinburgh

Wellcome Trust

Fingerprint Fingerprint is based on mining the text of the person's scientific documents to create an index of weighted terms, which defines the key subjects of each individual researcher.

  • 2 Similar Profiles
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Qa-SNARE Proteins Medicine & Life Sciences
Munc18 Proteins Medicine & Life Sciences
Cell Membrane Medicine & Life Sciences
Chromaffin Cells Medicine & Life Sciences

Co Author Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Research Output 1996 2019

  • 50 Article
  • 2 Conference contribution
  • 2 Other
  • 1 Chapter (peer-reviewed)

A VPS33A-binding motif on syntaxin17 controls autophagy completion in mammalian cells

Saleeb, R. S., Kavanagh, D. M., Dun, A. R., Dalgarno, P. A. & Duncan, R. R., 17 Jan 2019, In : Journal of Biological Chemistry.

Research output: Contribution to journalArticle

Open Access
File
Qa-SNARE Proteins
Autophagy
R-SNARE Proteins
SNARE Proteins
Munc18 Proteins

SWAP70 undergoes dynamic conformational regulation at the leading edge of migrating cells

Kriplani, N., Duncan, R. R. & Leslie, N. R., 12 Jan 2019, In : FEBS Letters.

Research output: Contribution to journalArticle

Monomeric GTP-Binding Proteins
Actins
Fluorescence Resonance Energy Transfer
Biosensing Techniques
Actin Cytoskeleton

A 256 x 256, 100-kfps, 61% Fill-Factor SPAD Image Sensor for Time-Resolved Microscopy Applications

Gyongy, I., Calder, N., Davies, A., Dutton, N. A. W., Duncan, R. R., Rickman, C., Dalgarno, P. A. & Henderson, R. K., Feb 2018, In : IEEE Transactions on Electron Devices. 65, 2, p. 547-554 8 p.

Research output: Contribution to journalArticle

Open Access
File
Image sensors
Microscopic examination
Pixels
Avalanche diodes
Charge coupled devices

A catch-and-release approach to selective modification of accessible tyrosine residues

Allan, C., Kosar, M., Burr, C. V., Mackay, C. L., Duncan, R. R. & Hulme, A. N., 13 Sep 2018, In : ChemBioChem.

Research output: Contribution to journalArticle

Tyrosine
Proteins
Benchmarking
Static Electricity
Sepharose

Cylindrical microlensing for enhanced collection efficiency of small pixel SPAD arrays in single-molecule localisation microscopy

Gyongy, I., Davies, A., Gallinet, B., Dutton, N. A. W., Duncan, R. R., Rickman, C., Henderson, R. K. & Dalgarno, P. A., 5 Feb 2018, In : Optics Express. 26, 3, p. 2280-2291 12 p.

Research output: Contribution to journalArticle

Open Access
File
avalanches
photodiodes
pixels
microscopy
photons

Prizes

Wellcome Trust Research Career Development Fellowship

Rory R. Duncan (Recipient), 2004

Prize: Fellowship awarded competitively

Activities 2012 2018

Scottish Parliament (External organisation)

Duncan, R. R. (Chair)
1 Mar 20181 May 2020

Activity: MembershipMembership of Advisory Panel

Science & Technology Facilities Council (External organisation)

Duncan, R. R. (Chair)
20172018

Activity: MembershipMembership of Advisory Panel

Science, jellyfish, science and art

Duncan, R. R. (Speaker)
1 Apr 2016

Activity: Talk or presentationPublic lecture

Science, jellyfish, galaxies and art

Duncan, R. R. (Speaker)
10 Nov 2015

Activity: Talk or presentationPublic lecture

Journal of Biological Chemistry (Journal)

Duncan, R. R. (Editorial board member)
20152019

Activity: Publication peer-review and editorial workEditorial activity

Press / Media