Personal profile
Biography
Paul Dalgarno leads the Advanced Microscopy Group at Heriot-Watt University, which specializes in developing new microscopy and analytical techniques for the life sciences. His primary work focusses on interdisciplinary collaborations with core activities based on 4D imaging, multi-parameter microscopy, fluorescent lifetime imaging and the application of single photon detector arrays to life science imaging. Paul is heavily involved in public outreach and engagement leading activities and in 2017 he won the Heriot-Watt student association Switched-On teaching Oscar for most exciting, enthusiastic and dynamic lecturer.
Paul obtained an MPhys degree in physics in 2001 before graduating with a PhD from Heriot-Watt in 2005 on the study of self-assembled semiconductor quantum dots. He worked until 2009 on semiconductor quantum optics, notably single photon sources, quantum dot physics and microcavities, before moving to St Andrews to study single molecule spectroscopy of RNA. In 2011 Paul returned to Heriot Watt as a research fellow in the newly formed Institute of Biological Chemistry, Biophysics and Bioengineering (IB3). Since 2012 Paul has been an Assistant Professor and group leader of the Advanced Microscopy Group.
Research interests
Pauls research is based on developing novel optical and analytical techniques in order to address fundamental problems in the life sciences. Example methods include real time 3D cellular imaging, time resolved spectroscopy, multi-parameter micrsocopy, single moelcule detection and correlation imaging.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
-
SDG 3 Good Health and Well-being
Fingerprint
- 1 Similar Profiles
Collaborations and top research areas from the last five years
-
OptoRheo: Live imaging of 3D cell cultures combined with local biomechanical sensing
Mendonca, T., Lis-Slimak, K., Matheson, A. B., Smith, M. G., Anane-Adjei, A. B., Ashworth, J. C., Cavanagh, R., Paterson, L., Dalgarno, P. A., Alexander, C., Tassieri, M., Merry, C. L. R. & Wright, A. J., 22 Sept 2025, In: EPJ Web of Conferences. 335, 04013.Research output: Contribution to journal › Conference article › peer-review
Open AccessFile2 Downloads (Pure) -
Fully angularly resolved 3D microrheology with optical tweezers
Matheson, A. B., Mendonca, T., Smith, M. G., Sutcliffe, B., Fernandez, A. J., Paterson, L., Dalgarno, P. A., Wright, A. J. & Tassieri, M., Mar 2024, In: Rheologica Acta. 63, 3, p. 205-217 13 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile1 Link opens in a new tab Citation (Scopus)89 Downloads (Pure) -
Optical tweezers with integrated multiplane microscopy
Paterson, L., Matheson, A., Wright, A. J., Mendonca, T., Tassieri, M. & Dalgarno, P. A., 27 Apr 2023.Research output: Contribution to conference › Paper
-
OptoRheo: Simultaneous in situ micro-mechanical sensing and imaging of live 3D biological systems
Mendonca, T., Lis-Slimak, K., Matheson, A. B., Smith, M. G., Anane-Adjei, A. B., Ashworth, J. C., Cavanagh, R., Paterson, L., Dalgarno, P. A., Alexander, C., Tassieri, M., Merry, C. L. R. & Wright, A. J., 28 Apr 2023, In: Communications Biology. 6, 463.Research output: Contribution to journal › Article › peer-review
Open AccessFile12 Link opens in a new tab Citations (Scopus)123 Downloads (Pure) -
An analytical framework for 3D microrheology measurements using an optical trap
Matheson, A., Mendonca, T., Smith, M., Sutcliffe, B., Paterson, L., Dalgarno, P. A., Wright, A. J. & Tassieri, M., 19 Oct 2022.Research output: Working paper › Preprint
Open Access
Activities
-
Multi-plane imaging and its application to 3D live cell particle tracking
Dalgarno, P. A. (Speaker)
6 Jul 2017Activity: Talk or presentation › Invited talk
-
Super-resolution, Multi-dimensional Microscopy for Cellular Imaging
Dalgarno, P. A. (Speaker)
7 Dec 2016Activity: Talk or presentation › Invited talk
-
Enlightenment: molecules, brains, light and art
Dalgarno, P. (Speaker)
13 Apr 2015Activity: Talk or presentation › Public lecture
-
'InnovationLight' public lecture, part of Innovation Nation
Dalgarno, P. (Speaker)
26 Nov 2015Activity: Talk or presentation › Public lecture
-
Press/Media
-
Optoforce - bespoke new instrument for optical imaging, micro-mechanical-sensing and the chemical perturbation of 3D cell cultures
Paterson, L., Dalgarno, P. A., Matheson, A., Alexander, C., Tassieri, M., Wright, A. J., Mendonca, T., Merry, C., Anane-Adjei, A. & Lis-Slimak, K.
31/05/21
1 Media contribution
Press/Media: Research
-
What do biologists, physicists and jellyfish have in common?
Duncan, R. & Dalgarno, P.
23/06/15
2 Media contributions
Press/Media: Research