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Paul Dalgarno leads the Advanced Microscopy Group at Heriot-Watt University, which specializes in developing new microscopy and analytical techniques for the life sciences. His primary work focusses on interdisciplinary collaborations with core activities based on 4D imaging, multi-parameter microscopy, fluorescent lifetime imaging and the application of single photon detector arrays to life science imaging. Paul is heavily involved in public outreach and engagement leading activities and in 2017 he won the Heriot-Watt student association Switched-On teaching Oscar for most exciting, enthusiastic and dynamic lecturer.

Paul obtained an MPhys degree in physics in 2001 before graduating with a PhD from Heriot-Watt in 2005 on the study of self-assembled semiconductor quantum dots. He worked until 2009 on semiconductor quantum optics, notably single photon sources, quantum dot physics and microcavities, before moving to St Andrews to study single molecule spectroscopy of RNA. In 2011 Paul returned to Heriot Watt as a research fellow in the newly formed Institute of Biological Chemistry, Biophysics and Bioengineering (IB3). Since 2012 Paul has been an Assistant Professor and group leader of the Advanced Microscopy Group.

Research interests

Pauls research is based on developing novel optical and analytical techniques in order to address fundamental problems in the life sciences. Example methods include real time 3D cellular imaging, time resolved spectroscopy, multi-parameter micrsocopy, single moelcule detection and correlation imaging.

Fingerprint Fingerprint is based on mining the text of the person's scientific documents to create an index of weighted terms, which defines the key subjects of each individual researcher.

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Co Author Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Research Output 2002 2019

A VPS33A-binding motif on syntaxin17 controls autophagy completion in mammalian cells

Saleeb, R. S., Kavanagh, D. M., Dun, A. R., Dalgarno, P. A. & Duncan, R. R., 17 Jan 2019, In : Journal of Biological Chemistry.

Research output: Contribution to journalArticle

Open Access
Qa-SNARE Proteins
R-SNARE Proteins
SNARE Proteins
Munc18 Proteins

High-speed dual color fluorescence lifetime endomicroscopy for highly-multiplexed pulmonary diagnostic applications and detection of labeled bacteria

Pedretti, E., Tanner, M. G., Choudhary, T. R., Krstajić, N., Megia-Fernandez, A., Henderson, R. K., Bradley, M., Thomson, R. R., Girkin, J. M., Dhaliwal, K. & Dalgarno, P. A., 1 Jan 2019, In : Biomedical Optics Express. 10, 1, p. 181-195 15 p.

Research output: Contribution to journalArticle

Open Access
high speed
life (durability)

A 256 x 256, 100-kfps, 61% Fill-Factor SPAD Image Sensor for Time-Resolved Microscopy Applications

Gyongy, I., Calder, N., Davies, A., Dutton, N. A. W., Duncan, R. R., Rickman, C., Dalgarno, P. A. & Henderson, R. K., Feb 2018, In : IEEE Transactions on Electron Devices. 65, 2, p. 547-554 8 p.

Research output: Contribution to journalArticle

Open Access
Image sensors
Microscopic examination
Avalanche diodes
Charge coupled devices

Cylindrical microlensing for enhanced collection efficiency of small pixel SPAD arrays in single-molecule localisation microscopy

Gyongy, I., Davies, A., Gallinet, B., Dutton, N. A. W., Duncan, R. R., Rickman, C., Henderson, R. K. & Dalgarno, P. A., 5 Feb 2018, In : Optics Express. 26, 3, p. 2280-2291 12 p.

Research output: Contribution to journalArticle

Open Access

Development of Super-resolution Sharpness-based Axial Localization for Ultrasound Imaging

Diamantis, K., Anderson, T., Jensen, J. A., Dalgarno, P. A. & Sboros, V., 24 Dec 2018, In : IEEE Access.

Research output: Contribution to journalArticle

Open Access
Imaging techniques
Synthetic apertures
Signal to noise ratio

Activities 2013 2017

  • 5 Participation in Festival or Exhibition
  • 5 Public lecture
  • 2 Invited talk
  • 2 School Outreach

Multi-plane imaging and its application to 3D live cell particle tracking

Dalgarno, P. A. (Speaker)
6 Jul 2017

Activity: Talk or presentationInvited talk

Super-resolution, Multi-dimensional Microscopy for Cellular Imaging

Dalgarno, P. A. (Speaker)
7 Dec 2016

Activity: Talk or presentationInvited talk

Enlightenment: molecules, brains, light and art

Dalgarno, P. A. (Speaker)
13 Apr 2015

Activity: Talk or presentationPublic lecture

'InnovationLight' public lecture, part of Innovation Nation

Dalgarno, P. A. (Speaker)
26 Nov 2015

Activity: Talk or presentationPublic lecture

Beyond the naked eye

Dalgarno, P. A. (Speaker)
6 Jun 2015

Activity: Talk or presentationPublic lecture

Press / Media