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Personal profile

Biography

Paul Dalgarno leads the Advanced Microscopy Group at Heriot-Watt University, which specializes in developing new microscopy and analytical techniques for the life sciences. His primary work focusses on interdisciplinary collaborations with core activities based on 4D imaging, multi-parameter microscopy, fluorescent lifetime imaging and the application of single photon detector arrays to life science imaging. Paul is heavily involved in public outreach and engagement leading activities and in 2017 he won the Heriot-Watt student association Switched-On teaching Oscar for most exciting, enthusiastic and dynamic lecturer.

Paul obtained an MPhys degree in physics in 2001 before graduating with a PhD from Heriot-Watt in 2005 on the study of self-assembled semiconductor quantum dots. He worked until 2009 on semiconductor quantum optics, notably single photon sources, quantum dot physics and microcavities, before moving to St Andrews to study single molecule spectroscopy of RNA. In 2011 Paul returned to Heriot Watt as a research fellow in the newly formed Institute of Biological Chemistry, Biophysics and Bioengineering (IB3). Since 2012 Paul has been an Assistant Professor and group leader of the Advanced Microscopy Group.

Research interests

Pauls research is based on developing novel optical and analytical techniques in order to address fundamental problems in the life sciences. Example methods include real time 3D cellular imaging, time resolved spectroscopy, multi-parameter micrsocopy, single moelcule detection and correlation imaging.

Fingerprint Dive into the research topics where Paul A. Dalgarno is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

quantum dots Physics & Astronomy
excitons Physics & Astronomy
Avalanches Medicine & Life Sciences
photons Physics & Astronomy
avalanche diodes Physics & Astronomy
Photons Medicine & Life Sciences
life (durability) Physics & Astronomy
Image sensors Engineering & Materials Science

Co Author Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Research Output 2002 2019

A comparison between image and signal sharpness-based axial localization of ultrasound scatterers

Diamantis, K., Dalgarno, P. A., Anderson, T., Jensen, J. A. & Sboros, V., 11 Jul 2019, 2019 IEEE 16th International Symposium on Biomedical Imaging (ISBI 2019). IEEE, p. 1610-1613 4 p. (International Symposium on Biomedical Imaging).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Ultrasonics
Image processing
Synthetic apertures
Microbubbles
Transducers

A VPS33A-binding motif on syntaxin17 controls autophagy completion in mammalian cells

Saleeb, R. S., Kavanagh, D. M., Dun, A. R., Dalgarno, P. A. & Duncan, R. R., 15 Mar 2019, In : Journal of Biological Chemistry. 294, 11, p. 4188-4201 14 p.

Research output: Contribution to journalArticle

Open Access
File
Qa-SNARE Proteins
Autophagy
R-SNARE Proteins
SNARE Proteins
Fusion reactions

Fluorescence lifetime imaging of high-speed particles with single-photon image sensors

Gyongy, I., Green, A., Hutchings, S. W., Davies, A., Dutton, N. A. W., Duncan, R. R., Rickman, C., Henderson, R. K. & Dalgarno, P. A., 4 Mar 2019, High-Speed Biomedical Imaging and Spectroscopy IV. Tsia, K. K. & Goda, K. (eds.). SPIE, 108890O. (Proceedings of SPIE; vol. 10889).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Optical Imaging
Photons
Avalanches
Image sensors
Avalanche diodes

High-speed dual color fluorescence lifetime endomicroscopy for highly-multiplexed pulmonary diagnostic applications and detection of labeled bacteria

Pedretti, E., Tanner, M. G., Choudhary, T. R., Krstajić, N., Megia-Fernandez, A., Henderson, R. K., Bradley, M., Thomson, R. R., Girkin, J. M., Dhaliwal, K. & Dalgarno, P. A., 1 Jan 2019, In : Biomedical Optics Express. 10, 1, p. 181-195 15 p.

Research output: Contribution to journalArticle

Open Access
File
bacteria
high speed
color
life (durability)
fluorescence

Unveiling the multi-step solubilization mechanism of sub-micron size vesicles by detergents

Dalgarno, P. A., Juan-Colás, J., Hedley, G. J., Piñeiro, L., Novo, M., Perez-Gonzalez, C., Samuel, I. D. W., Leake, M. C., Johnson, S., Al-Soufi, W., Penedo, J. C. & Quinn, S. D., 9 Sep 2019, In : Scientific Reports. 9, 1, 12897.

Research output: Contribution to journalArticle

Open Access
File
Detergents
Energy Transfer
Quartz Crystal Microbalance Techniques
Lipids
Fluorescence Spectrometry

Activities 2013 2017

  • 5 Participation in Festival or Exhibition
  • 5 Public lecture
  • 2 Invited talk
  • 2 School Outreach

Multi-plane imaging and its application to 3D live cell particle tracking

Paul A. Dalgarno (Speaker)
6 Jul 2017

Activity: Talk or presentationInvited talk

Super-resolution, Multi-dimensional Microscopy for Cellular Imaging

Paul A. Dalgarno (Speaker)
7 Dec 2016

Activity: Talk or presentationInvited talk

'InnovationLight' public lecture, part of Innovation Nation

Paul Dalgarno (Speaker)
26 Nov 2015

Activity: Talk or presentationPublic lecture

Enlightenment: molecules, brains, light and art

Paul Dalgarno (Speaker)
13 Apr 2015

Activity: Talk or presentationPublic lecture

Beyond the naked eye

Paul Dalgarno (Speaker)
6 Jun 2015

Activity: Talk or presentationPublic lecture

Press / Media

What do biologists, physicists and jellyfish have in common?

Paul Dalgarno

23/06/15

1 Media contribution

Press/Media: Research