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Research Output 1999 2018

2018

Batch anaerobic digestion of deproteinated malt whisky pot ale using different source inocula

Barrena, R., Traub-Modinger, J., Rodriguez Gill, C., Goodwin, J. A. S., Harper, A., Willoughby, N., Sánchez, A. & Aspray, T. J., Jan 2018, In : Waste Management. 71, p. 675-682 8 p.

Research output: Contribution to journalArticle

Open Access
File
Digestion
Methane
Biological Oxygen Demand Analysis
Biofuels
Centrifugation

Impact of poloxamer 188 (Pluronic F-68) additive on cell mechanical properties, quantification by real-time deformability cytometry

Guzniczak, E., Jimenez, M., Irwin, M., Otto, O., Willoughby, N. & Bridle, H., 22 Aug 2018, In : Biomicrofluidics. 12, 4, 044118.

Research output: Contribution to journalArticle

Poloxamer
cytometry
Formability
mechanical properties
Mechanical properties
2017

Challenges and advances in scale-up of label-free downstream processing for allogeneic cell therapies

Masri, F., Hoeve, M. A., De Sousa, P. A. & Willoughby, N. A., 4 Aug 2017, In : Cell and Gene Therapy Insights. 3, 6, p. 447-467 21 p.

Research output: Contribution to journalReview article

Open Access
File
Scalability
Labels
Centrifugation
Processing
Stem cells

Effect of organic carbon enrichment on the treatment efficiency of primary settled wastewater by Chlorella vulgaris

Evans, L., Hennige, S. J., Willoughby, N., Adeloye, A., Skroblin, M. & Gutierrez, T., Jun 2017, In : Algal Research. 24, Part A, p. 368–377

Research output: Contribution to journalArticle

Open Access
File
organic carbon
wastewater
inorganic compound
bioreactor
aeration

High-throughput assessment of mechanical properties of stem cell derived red blood cells, toward cellular downstream processing

Guzniczak, E., Mohammad Zadeh, M., Dempsey, F., Jimenez, M., Bock, H., Whyte, G., Willoughby, N. & Bridle, H., 31 Oct 2017, In : Scientific Reports. 7, 14457.

Research output: Contribution to journalArticle

Open Access
File
Stem Cells
Erythrocytes
Elastic Modulus
Cell Nucleus
Atomic Force Microscopy

Optically enhanced acoustophoresis

McDougall, C., O'Mahoney, P., McGuinn, A., Willoughby, N. A., Qiu, Y., Demore, C. E. M. & MacDonald, M. P., 25 Aug 2017, Optical Trapping and Optical Micromanipulation XIV. Dholakia, K. & Spalding, G. C. (eds.). SPIE, 103471B. (Proceedings of SPIE; vol. 10347).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

classifying
Sorting
bioprocessing
nonconservative forces
Cell
2016

A scalable label-free approach to separate human pluripotent cells from differentiated derivatives

Bock, H., Willoughby, N., Hoeve, M., Pells, S., Williams, C., McPhee, G., Freile, P., Choudhury, D. & De Sousa, P., Jan 2016, In : Biomicrofluidics. 10, 16 p., 014107.

Research output: Contribution to journalArticle

Open Access
File
Elastic Modulus
Equipment and Supplies
Fibroblasts
Population
Pluripotent Stem Cells

Challenges of Scale-up of Cell Separation and Purification Techniques

Hoeve, M. A., De Sousa, P. A. & Willoughby, N. A., 16 Dec 2016, Bioprocessing for Cell Based Therapies. Connon, C. J. (ed.). Wiley-Blackwell, p. 127-165 39 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Cell Separation
Purification
Cells
Processing
Health

Creating an new market opportunity for whisky by-products: challenges and opportunities

Maskell, D. L., White, J., Traub-Modinger, J., Diallo, A., Hughes, P., Harper, A. & Willoughby, N., Mar 2016.

Research output: Contribution to conferencePaper

whisky
new markets
byproducts
industry
malt

Effect of CO2 aeration on cultivation of microalgae in luminescent photobioreactors

Mohsenpour, S. F. & Willoughby, N., Feb 2016, In : Biomass and Bioenergy. 85, p. 168-177 10 p.

Research output: Contribution to journalArticle

microalgae
aeration
carbon dioxide
lipid content
air

Effect of organic carbon enrichment on the treatment efficiency of primary settled wastewater by Chlorella vulgaris

Evans, L., Hennige, S. J., Gutierrez, T., Adeloye, A. & Willoughby, N., 25 Jul 2016, In : New Biotechnology . 33, Supplement, p. S56

Research output: Contribution to journalMeeting abstract

Physicochemical characterisation and batch anaerobic digestion of malt whisky pot ale following a high efficiency deproteination pre-treatment process

Barrena, R., Traub, J. E., Rodriguez Gill, C., Goodwin, J. A. S., Harper, A., Willoughby, N., Sanchez, A. & Aspray, T. J., 14 Nov 2016.

Research output: Contribution to conferencePaper

Protein Recovery

Traub-Modinger, J., White, J., Maskell, D. L., Harper, A., Hughes, P. & Willoughby, N., 7 Jan 2016, IPC No. C07K 1/14 (2006.01), A23K 1/00 (2006.01), C07K 14/81 (2006.01) , Patent No. GB2015/051944, Priority date 3 Jul 2014, Priority No. 1411943.2

Research output: Patent

proteins
food additives
distillation
ingredients

Recovery and Applications of Proteins from Distillery By-Products

White, J. S., Traub, J. E., Maskell, D. L., Hughes, P. S., Harper, A. J. & Willoughby, N. A., 2016, Protein Byproducts: Transformation from Environmental Burden Into Value-Added Products. Dhillon, G. S. (ed.). Elsevier, p. 235-253 19 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Distilleries
byproducts
Byproducts
Proteins
Recovery
2015

Creating a new market opportunity for whisky by-products

Maskell, D. L., White, J., Traub-Modinger, J., Hughes, P. & Willoughby, N., Sep 2015, Worldwide Distilled Spirits Conference: Future Challenges, New Solutions. Goodall, I., Fotheringham, R., Murray, D., Speers, A. & Walker, G. (eds.). Nottingham, United Kingdom: Context, Vol. 5. p. 367-370 4 p.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2014

Development of luminescent photobioreactors for improved microalgae cultivation

Mohsenpour, S. F. & Willoughby, N., Jul 2014, In : New Biotechnology . 31, p. S26-S26 1 p.

Research output: Contribution to journalMeeting abstract

Whisky by-products: a valuable source of protein and potential applications in aquaculture

White, J., Traub, J., Maskell, D., Hughes, P., Harper, A. & Willoughby, N., Jul 2014, In : New Biotechnology . 31, p. S118-S118 1 p.

Research output: Contribution to journalMeeting abstract

2013
Photobioreactors
Microalgae
Light
Chlorophyll
Growth
2012

A 3D mammalian cell separator biochip

Choudhury, D., Ramsay, W. T., Kiss, R., Willoughby, N. A., Paterson, L. & Kar, A. K., 2012, In : Lab on a Chip. 12, 5, p. 948-953 6 p.

Research output: Contribution to journalArticle

Open Access
File

Industrially Generated Red Blood Cells for Transfusion

Willoughby, N., Dempsey, F. & Mountford, J., 2012.

Research output: Contribution to conferencePaper

Erythrocyte Transfusion
Erythrocytes
Bioengineering
Blood Donors
Blood Transfusion

Spectral conversion of light for enhanced microalgae growth rates and photosynthetic pigment production

Mohsenpour, S. F., Richards, B. & Willoughby, N., 2012, In : Bioresource Technology. 125, -, p. 75–81

Research output: Contribution to journalArticle

Microalgae
Light
Growth
Lighting
Chlorella vulgaris
2011

A femtosecond laser inscribed biochip for stem cell therapeutic applications

Choudhury, D., Ramsay, W. T., Brown, G., Psaila, N. D., Beecher, S., Thomson, R. R., Kiss, R., Pells, S., Willoughby, N. A., Paterson, L. & Kar, A. K., 2011, Microfluidics, BioMEMS, and Medical Microsystems IX. Becker, H. & Gray, BL. (eds.). BELLINGHAM: SPIE, Vol. 7929. p. - 6 p.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Cell Separation
Elasticity
Lasers
Stem Cells
Equipment and Supplies

Elasticity of Human Embryonic Stem Cells as Determined by Atomic Force Microscopy

Kiss, R., Bock, H., Pells, S., Canetta, E., Adya, A. K., Moore, A. J., De Sousa, P. & Willoughby, N. A., Oct 2011, In : Journal of Biomechanical Engineering. 133, 10, p. - 9 p., 101009.

Research output: Contribution to journalArticle

Ultrafast laser inscription: Science today, technology tomorrow

Choudhury, D., Ramsay, W. T., Willoughby, N. A., Paterson, L. & Kar, A. K., 29 Nov 2011, Passive Components and Fiber-based Devices VIII. Pal, B. P. (ed.). Bellingham (Washington State): SPIE, 11 p. (Passive Components and Fiber-based Devices; vol. 8).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2010

Sorting stem cells using a femtosecond laser inscribed biochip

Choudhury, D., Ramsay, W. T., Psaila, N. D., Brown, G., Beecher, S., Paterson, L., Kar, A. K., Kiss, R., Willoughby, N. A. & Pell, S., 2010, 2010 23RD ANNUAL MEETING OF THE IEEE PHOTONICS SOCIETY. NEW YORK: IEEE, p. 216-217 2 p.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2009
Column chromatography
Purification
Gene therapy
Molecules
Industry
2008

Large-scale plasmid DNA processing: Evidence that cell harvesting and storage methods affect yield of supercoiled plasmid DNA

Kong, S., Rock, C. F., Booth, A., Willoughby, N., O'Kennedy, R. D., Relton, J., Ward, J. M., Hoare, M. & Levy, M. S., Sep 2008, In : Biotechnology and Applied Biochemistry. 51, 1, p. 43-51 9 p.

Research output: Contribution to journalArticle

cell harvesting
plasmids
centrifuges
cells
centrifugation

Rhythm of the seers

Willoughby, N., 24 May 2008, In : New Scientist. 198, 2657, p. 21-

Research output: Contribution to journalLetter

2007

Adapted ultra scale-down approach for predicting the centrifugal separation behavior of high cell density cultures

Tustian, A. D., Salte, H., Willoughby, N. A., Hassan, I., Rose, M. H., Baganz, F., Hoare, M. & Titchener-Hooker, N. J., Nov 2007, In : Biotechnology Progress. 23, 6, p. 1404-1410 7 p.

Research output: Contribution to journalArticle

Cell culture
Cells
Dilution
Centrifuges
Engineers
2005

Determining particle density distribution of expanded bed adsorbents

Hassan, S., Titchener-Hooker, N. & Willoughby, N., 5 Dec 2005, In : Biotechnology and Bioengineering. 92, 5, p. 659-663 5 p.

Research output: Contribution to journalArticle

Trifluoroacetic Acid
Particle Size
Adsorption
Porosity
Hydrodynamics
2004

Extreme scale-down of expanded bed adsorption: Purification of an antibody fragment directly from recombinant E. coli culture

Willoughby, N., Martin, P. & Titchener-Hooker, N., 5 Sep 2004, In : Biotechnology and Bioengineering. 87, 5, p. 641-647 7 p.

Research output: Contribution to journalArticle

Immunoglobulin Fragments
Adsorption
Escherichia coli
Equipment and Supplies
Ion Exchange Chromatography

Use of dimensionless residence time to study variations in breakthrough behaviour in expanded beds formed from varied particle size distributions

Gardner, P. J., Willoughby, N., Hjorth, R., Lacki, K. & Titchener-Hooker, N. J., 5 Aug 2004, In : Biotechnology and Bioengineering. 87, 3, p. 347-353 7 p.

Research output: Contribution to journalArticle

Alcohol Dehydrogenase
Particle Size
2000

Experimental measurement of particle size distribution and voidage in an expanded bed adsorption system

Willoughby, N. A., Hjorth, R. & Titchener-Hooker, N. J., 20 Sep 2000, In : Biotechnology and Bioengineering. 69, 6, p. 648-653 6 p.

Research output: Contribution to journalArticle

Particle Size
Adsorption
Adsorption
Alcohol Dehydrogenase
Enzymes
Reaction Time
Saccharomyces cerevisiae
1999

Immobilised metal ion affinity chromatography purification of alcohol dehydrogenase from baker's yeast using an expanded bed adsorption system

Willoughby, N. A., Kirschner, T., Smith, M. P., Hjorth, R. & Titchener-Hooker, N. J., 30 Apr 1999, In : Journal of Chromatography A. 840, 2, p. 195-204 10 p.

Research output: Contribution to journalArticle

Affinity chromatography
Ion chromatography
Alcohol Dehydrogenase
Affinity Chromatography
Edetic Acid